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Light alcohol drinking and cancer: a meta-analysis.
Ann Oncol 2013; 24(2):301-8AO

Abstract

BACKGROUND

There is convincing evidence that alcohol consumption increases the risk of cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx. Most of the data derive from studies that focused on the effect of moderate/high alcohol intakes, while little is known about light alcohol drinking (up to 1 drink/day).

PATIENTS AND METHODS

We evaluated the association between light drinking and cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx, through a meta-analytic approach. We searched epidemiological studies using PubMed, ISI Web of Science and EMBASE, published before December 2010.

RESULTS

We included 222 articles comprising ∼92 000 light drinkers and 60 000 non-drinkers with cancer. Light drinking was associated with the risk of oropharyngeal cancer [relative risk, RR = 1.17; 95% confidence interval (CI) 1.06-1.29], esophageal squamous cell carcinoma (SCC) (RR = 1.30; 95% CI 1.09-1.56) and female breast cancer (RR = 1.05; 95% CI 1.02-1.08). We estimated that ∼5000 deaths from oropharyngeal cancer, 24 000 from esophageal SCC and 5000 from breast cancer were attributable to light drinking in 2004 worldwide. No association was found for colorectum, liver and larynx tumors.

CONCLUSIONS

Light drinking increases the risk of cancer of oral cavity and pharynx, esophagus and female breast.

Authors+Show Affiliations

Department of Statistics, University of Milan-Bicocca, Milan, Italy. vincenzo.bagnardi@unimib.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22910838

Citation

Bagnardi, V, et al. "Light Alcohol Drinking and Cancer: a Meta-analysis." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 24, no. 2, 2013, pp. 301-8.
Bagnardi V, Rota M, Botteri E, et al. Light alcohol drinking and cancer: a meta-analysis. Ann Oncol. 2013;24(2):301-8.
Bagnardi, V., Rota, M., Botteri, E., Tramacere, I., Islami, F., Fedirko, V., ... La Vecchia, C. (2013). Light alcohol drinking and cancer: a meta-analysis. Annals of Oncology : Official Journal of the European Society for Medical Oncology, 24(2), pp. 301-8. doi:10.1093/annonc/mds337.
Bagnardi V, et al. Light Alcohol Drinking and Cancer: a Meta-analysis. Ann Oncol. 2013;24(2):301-8. PubMed PMID: 22910838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Light alcohol drinking and cancer: a meta-analysis. AU - Bagnardi,V, AU - Rota,M, AU - Botteri,E, AU - Tramacere,I, AU - Islami,F, AU - Fedirko,V, AU - Scotti,L, AU - Jenab,M, AU - Turati,F, AU - Pasquali,E, AU - Pelucchi,C, AU - Bellocco,R, AU - Negri,E, AU - Corrao,G, AU - Rehm,J, AU - Boffetta,P, AU - La Vecchia,C, Y1 - 2012/08/21/ PY - 2012/8/23/entrez PY - 2012/8/23/pubmed PY - 2013/7/3/medline SP - 301 EP - 8 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann. Oncol. VL - 24 IS - 2 N2 - BACKGROUND: There is convincing evidence that alcohol consumption increases the risk of cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx. Most of the data derive from studies that focused on the effect of moderate/high alcohol intakes, while little is known about light alcohol drinking (up to 1 drink/day). PATIENTS AND METHODS: We evaluated the association between light drinking and cancer of the colorectum, breast, larynx, liver, esophagus, oral cavity and pharynx, through a meta-analytic approach. We searched epidemiological studies using PubMed, ISI Web of Science and EMBASE, published before December 2010. RESULTS: We included 222 articles comprising ∼92 000 light drinkers and 60 000 non-drinkers with cancer. Light drinking was associated with the risk of oropharyngeal cancer [relative risk, RR = 1.17; 95% confidence interval (CI) 1.06-1.29], esophageal squamous cell carcinoma (SCC) (RR = 1.30; 95% CI 1.09-1.56) and female breast cancer (RR = 1.05; 95% CI 1.02-1.08). We estimated that ∼5000 deaths from oropharyngeal cancer, 24 000 from esophageal SCC and 5000 from breast cancer were attributable to light drinking in 2004 worldwide. No association was found for colorectum, liver and larynx tumors. CONCLUSIONS: Light drinking increases the risk of cancer of oral cavity and pharynx, esophagus and female breast. SN - 1569-8041 UR - https://www.unboundmedicine.com/medline/citation/22910838/Light_alcohol_drinking_and_cancer:_a_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0923-7534(19)36858-9 DB - PRIME DP - Unbound Medicine ER -