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Increased dietary fruit intake was associated with lower burden of carotid atherosclerosis in Chinese patients with Type 2 diabetes mellitus.
Diabet Med 2013; 30(1):100-8DM

Abstract

BACKGROUND

Previous studies demonstrated that high fruit consumption was associated with a lower risk of cardiovascular events in patients with Type 2 diabetes mellitus. However, the relationship between fruit intake and carotid atherosclerosis in these patients is unknown. We studied the relationship between dietary fruit intake and carotid intima-media thickness in patients with Type 2 diabetes.

METHODS

A total of 255 Chinese patients with Type 2 diabetes were recruited. Dietary fruit intake was assessed by a validated food-frequency questionnaire, and carotid intima-media thickness was measured by high-resolution ultrasonography.

RESULTS

Among patients with three different tertiles of fruit intake (14.5 ± 8.6 vs. 41.5 ± 7.1 vs. 92.6 ± 39.7 g/day), there was no difference in their clinical characteristics (all P > 0.05). Patients with the highest tertile of fruit intake had a significantly higher BMI and diastolic blood pressure than those with the lowest tertile intake. Furthermore, serum high-sensitivity C-reactive protein, 8-isoprostane and superoxide dismutase were similar among the three tertiles of patients (all P > 0.05). However, patients with the highest tertile of fruit intake had lower carotid intima-media thickness (0.97 ± 0.02 vs. 1.08 ± 0.03 mm, P = 0.046) and prevalence of carotid plaque (11.76 vs. 1.18%, P = 0.022) than those with the lowest tertile of fruit intake. Multivariate regression analysis revealed the highest tertile of fruit intake (β = -0.086, P = 0.049) was independently associated with carotid intima-media thickness.

CONCLUSIONS

Our results demonstrated that, in Chinese patients with Type 2 diabetes, higher dietary fruit intake was associated with a lower burden of carotid atherosclerosis as reflected by lower carotid intima-media thickness and prevalence of carotid plaque.

Authors+Show Affiliations

Cardiology Division, Department of Medicine, the University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22913415

Citation

Chan, H-T, et al. "Increased Dietary Fruit Intake Was Associated With Lower Burden of Carotid Atherosclerosis in Chinese Patients With Type 2 Diabetes Mellitus." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 30, no. 1, 2013, pp. 100-8.
Chan HT, Yiu KH, Wong CY, et al. Increased dietary fruit intake was associated with lower burden of carotid atherosclerosis in Chinese patients with Type 2 diabetes mellitus. Diabet Med. 2013;30(1):100-8.
Chan, H. T., Yiu, K. H., Wong, C. Y., Li, S. W., Tam, S., & Tse, H. F. (2013). Increased dietary fruit intake was associated with lower burden of carotid atherosclerosis in Chinese patients with Type 2 diabetes mellitus. Diabetic Medicine : a Journal of the British Diabetic Association, 30(1), pp. 100-8. doi:10.1111/j.1464-5491.2012.03764.x.
Chan HT, et al. Increased Dietary Fruit Intake Was Associated With Lower Burden of Carotid Atherosclerosis in Chinese Patients With Type 2 Diabetes Mellitus. Diabet Med. 2013;30(1):100-8. PubMed PMID: 22913415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased dietary fruit intake was associated with lower burden of carotid atherosclerosis in Chinese patients with Type 2 diabetes mellitus. AU - Chan,H-T, AU - Yiu,K-H, AU - Wong,C-Y, AU - Li,S-W, AU - Tam,S, AU - Tse,H-F, PY - 2012/8/24/entrez PY - 2012/8/24/pubmed PY - 2013/5/18/medline SP - 100 EP - 8 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 30 IS - 1 N2 - BACKGROUND: Previous studies demonstrated that high fruit consumption was associated with a lower risk of cardiovascular events in patients with Type 2 diabetes mellitus. However, the relationship between fruit intake and carotid atherosclerosis in these patients is unknown. We studied the relationship between dietary fruit intake and carotid intima-media thickness in patients with Type 2 diabetes. METHODS: A total of 255 Chinese patients with Type 2 diabetes were recruited. Dietary fruit intake was assessed by a validated food-frequency questionnaire, and carotid intima-media thickness was measured by high-resolution ultrasonography. RESULTS: Among patients with three different tertiles of fruit intake (14.5 ± 8.6 vs. 41.5 ± 7.1 vs. 92.6 ± 39.7 g/day), there was no difference in their clinical characteristics (all P > 0.05). Patients with the highest tertile of fruit intake had a significantly higher BMI and diastolic blood pressure than those with the lowest tertile intake. Furthermore, serum high-sensitivity C-reactive protein, 8-isoprostane and superoxide dismutase were similar among the three tertiles of patients (all P > 0.05). However, patients with the highest tertile of fruit intake had lower carotid intima-media thickness (0.97 ± 0.02 vs. 1.08 ± 0.03 mm, P = 0.046) and prevalence of carotid plaque (11.76 vs. 1.18%, P = 0.022) than those with the lowest tertile of fruit intake. Multivariate regression analysis revealed the highest tertile of fruit intake (β = -0.086, P = 0.049) was independently associated with carotid intima-media thickness. CONCLUSIONS: Our results demonstrated that, in Chinese patients with Type 2 diabetes, higher dietary fruit intake was associated with a lower burden of carotid atherosclerosis as reflected by lower carotid intima-media thickness and prevalence of carotid plaque. SN - 1464-5491 UR - https://www.unboundmedicine.com/medline/citation/22913415/Increased_dietary_fruit_intake_was_associated_with_lower_burden_of_carotid_atherosclerosis_in_Chinese_patients_with_Type_2_diabetes_mellitus_ L2 - https://doi.org/10.1111/j.1464-5491.2012.03764.x DB - PRIME DP - Unbound Medicine ER -