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Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women.
Am J Clin Nutr. 2012 Oct; 96(4):781-8.AJ

Abstract

BACKGROUND

Although a high intake of some flavonoid subclasses may reduce cardiovascular disease mortality, data regarding the in vivo mechanisms of action are limited.

OBJECTIVE

We examined associations between habitual flavonoid intakes and direct measures of arterial stiffness, central blood pressure, and atherosclerosis.

DESIGN

In a cross-sectional study of 1898 women aged 18-75 y from the TwinsUK registry, intakes of total flavonoids and their subclasses (flavanones, anthocyanins, flavan-3-ols, polymers, flavonols, and flavones) were calculated from validated food-frequency questionnaires by using an updated and extended USDA database. Direct measures of arterial stiffness and atherosclerosis included central systolic blood pressure (cSBP), central diastolic blood pressure, mean arterial pressure (MAP), augmentation index, pulse wave velocity (PWV), and intima-media thickness.

RESULTS

In multivariate analyses, a higher anthocyanin intake was associated with significantly lower cSBP (mean ± SE: -3.0 ± 1.4 mm Hg for quintile 5 compared with quintile 1; P-trend = 0.02), MAP (-2.3 ± 1.2 mm Hg for quintile 5 compared with quintile 1; P-trend = 0.04), and PWV (-0.4 ± 0.2 m/s for quintile 5 compared with quintile 1; P-trend = 0.04), whereas a higher flavone intake was associated with a lower PWV (-0.4 ± 0.2 m/s for quintile 5 compared with quintile 1; P-trend = 0.04). Although a higher wine and berry intake was associated with a lower PWV, no associations were observed for total and other flavonoid subclasses.

CONCLUSIONS

These data, which include direct measures of arterial stiffness and thickness, suggest that higher intake of anthocyanins and flavones are inversely associated with lower arterial stiffness. The intakes of anthocyanins associated with these findings could be incorporated into the diet by the consumption of 1-2 portions of berries daily and are, therefore, relevant for public health strategies to reduce cardiovascular disease risk.

Authors+Show Affiliations

Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

22914551

Citation

Jennings, Amy, et al. "Higher Anthocyanin Intake Is Associated With Lower Arterial Stiffness and Central Blood Pressure in Women." The American Journal of Clinical Nutrition, vol. 96, no. 4, 2012, pp. 781-8.
Jennings A, Welch AA, Fairweather-Tait SJ, et al. Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women. Am J Clin Nutr. 2012;96(4):781-8.
Jennings, A., Welch, A. A., Fairweather-Tait, S. J., Kay, C., Minihane, A. M., Chowienczyk, P., Jiang, B., Cecelja, M., Spector, T., Macgregor, A., & Cassidy, A. (2012). Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women. The American Journal of Clinical Nutrition, 96(4), 781-8.
Jennings A, et al. Higher Anthocyanin Intake Is Associated With Lower Arterial Stiffness and Central Blood Pressure in Women. Am J Clin Nutr. 2012;96(4):781-8. PubMed PMID: 22914551.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women. AU - Jennings,Amy, AU - Welch,Ailsa A, AU - Fairweather-Tait,Sue J, AU - Kay,Colin, AU - Minihane,Anne-Marie, AU - Chowienczyk,Phil, AU - Jiang,Benyu, AU - Cecelja,Marina, AU - Spector,Tim, AU - Macgregor,Alex, AU - Cassidy,Aedín, Y1 - 2012/08/22/ PY - 2012/8/24/entrez PY - 2012/8/24/pubmed PY - 2012/12/12/medline SP - 781 EP - 8 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 96 IS - 4 N2 - BACKGROUND: Although a high intake of some flavonoid subclasses may reduce cardiovascular disease mortality, data regarding the in vivo mechanisms of action are limited. OBJECTIVE: We examined associations between habitual flavonoid intakes and direct measures of arterial stiffness, central blood pressure, and atherosclerosis. DESIGN: In a cross-sectional study of 1898 women aged 18-75 y from the TwinsUK registry, intakes of total flavonoids and their subclasses (flavanones, anthocyanins, flavan-3-ols, polymers, flavonols, and flavones) were calculated from validated food-frequency questionnaires by using an updated and extended USDA database. Direct measures of arterial stiffness and atherosclerosis included central systolic blood pressure (cSBP), central diastolic blood pressure, mean arterial pressure (MAP), augmentation index, pulse wave velocity (PWV), and intima-media thickness. RESULTS: In multivariate analyses, a higher anthocyanin intake was associated with significantly lower cSBP (mean ± SE: -3.0 ± 1.4 mm Hg for quintile 5 compared with quintile 1; P-trend = 0.02), MAP (-2.3 ± 1.2 mm Hg for quintile 5 compared with quintile 1; P-trend = 0.04), and PWV (-0.4 ± 0.2 m/s for quintile 5 compared with quintile 1; P-trend = 0.04), whereas a higher flavone intake was associated with a lower PWV (-0.4 ± 0.2 m/s for quintile 5 compared with quintile 1; P-trend = 0.04). Although a higher wine and berry intake was associated with a lower PWV, no associations were observed for total and other flavonoid subclasses. CONCLUSIONS: These data, which include direct measures of arterial stiffness and thickness, suggest that higher intake of anthocyanins and flavones are inversely associated with lower arterial stiffness. The intakes of anthocyanins associated with these findings could be incorporated into the diet by the consumption of 1-2 portions of berries daily and are, therefore, relevant for public health strategies to reduce cardiovascular disease risk. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22914551/Higher_anthocyanin_intake_is_associated_with_lower_arterial_stiffness_and_central_blood_pressure_in_women_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.112.042036 DB - PRIME DP - Unbound Medicine ER -