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Genetically manipulated progenitor/stem cells restore function to the infarcted heart via the SDF-1α/CXCR4 signaling pathway.
Prog Mol Biol Transl Sci. 2012; 111:265-84.PM

Abstract

Progenitor/stem cells are a viable option to replace myocytes lost subsequent to myocardial infarction (MI). The stromal cell-derived factor-1α/CXC-chemokine receptor type 4 (SDF-1α/CXCR4) axis plays an important role in numerous biological processes including hematopoiesis, cardiogenesis, vasculogenesis, and neuronal development, as well as endothelial progenitor cell trafficking. The secretion of chemoattractants such as SDF-1α at the site of injury creates an environment facilitating the homing of circulating CXCR4 positive and other stem cells (such as mast/stem cell growth factor receptor kit-positive (c-kit(+)) and c-kit(+)/GATA binding protein 4 positive (GATA4(+)) cells) for organ regeneration and tissue repair. SDF-1α is also secreted by hematopoietic progenitor/stem cells and is involved in the autocrine/paracrine regulation of their development and survival. Hypoxic preconditioning activates SDF-1α/CXCR4 signaling and upregulates several vascular/angiogenic factors that cause mobilization of progenitor cells. The SDF-1α/CXCR4 signaling pathway can thus be effectively exploited for cell-based therapy.

Authors+Show Affiliations

Department of Pathology and Laboratory Medicine, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22917235

Citation

Wang, Yigang, and Kristin Luther. "Genetically Manipulated Progenitor/stem Cells Restore Function to the Infarcted Heart Via the SDF-1α/CXCR4 Signaling Pathway." Progress in Molecular Biology and Translational Science, vol. 111, 2012, pp. 265-84.
Wang Y, Luther K. Genetically manipulated progenitor/stem cells restore function to the infarcted heart via the SDF-1α/CXCR4 signaling pathway. Prog Mol Biol Transl Sci. 2012;111:265-84.
Wang, Y., & Luther, K. (2012). Genetically manipulated progenitor/stem cells restore function to the infarcted heart via the SDF-1α/CXCR4 signaling pathway. Progress in Molecular Biology and Translational Science, 111, 265-84. https://doi.org/10.1016/B978-0-12-398459-3.00012-5
Wang Y, Luther K. Genetically Manipulated Progenitor/stem Cells Restore Function to the Infarcted Heart Via the SDF-1α/CXCR4 Signaling Pathway. Prog Mol Biol Transl Sci. 2012;111:265-84. PubMed PMID: 22917235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetically manipulated progenitor/stem cells restore function to the infarcted heart via the SDF-1α/CXCR4 signaling pathway. AU - Wang,Yigang, AU - Luther,Kristin, PY - 2012/8/25/entrez PY - 2012/8/25/pubmed PY - 2013/1/17/medline SP - 265 EP - 84 JF - Progress in molecular biology and translational science JO - Prog Mol Biol Transl Sci VL - 111 N2 - Progenitor/stem cells are a viable option to replace myocytes lost subsequent to myocardial infarction (MI). The stromal cell-derived factor-1α/CXC-chemokine receptor type 4 (SDF-1α/CXCR4) axis plays an important role in numerous biological processes including hematopoiesis, cardiogenesis, vasculogenesis, and neuronal development, as well as endothelial progenitor cell trafficking. The secretion of chemoattractants such as SDF-1α at the site of injury creates an environment facilitating the homing of circulating CXCR4 positive and other stem cells (such as mast/stem cell growth factor receptor kit-positive (c-kit(+)) and c-kit(+)/GATA binding protein 4 positive (GATA4(+)) cells) for organ regeneration and tissue repair. SDF-1α is also secreted by hematopoietic progenitor/stem cells and is involved in the autocrine/paracrine regulation of their development and survival. Hypoxic preconditioning activates SDF-1α/CXCR4 signaling and upregulates several vascular/angiogenic factors that cause mobilization of progenitor cells. The SDF-1α/CXCR4 signaling pathway can thus be effectively exploited for cell-based therapy. SN - 1878-0814 UR - https://www.unboundmedicine.com/medline/citation/22917235/Genetically_manipulated_progenitor/stem_cells_restore_function_to_the_infarcted_heart_via_the_SDF_1α/CXCR4_signaling_pathway_ L2 - https://linkinghub.elsevier.com/retrieve/pii/B978-0-12-398459-3.00012-5 DB - PRIME DP - Unbound Medicine ER -