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Follicular center helper T-cell (TFH) marker positive mycosis fungoides/Sezary syndrome.
Mod Pathol 2013; 26(1):32-43MP

Abstract

We identified 11 patients with CD10(+) cutaneous T-cell lymphoma by flow cytometry. All cases were CD4(+) and CD8(-). Three patients had extensive lymphadenopathy, systemic symptoms and an aggressive clinical course consistent with angioimmunoblastic T-cell lymphoma or peripheral T-cell lymphoma. However, 8 of the 11 patients had a prolonged disease course with gross morphology, histology and tumor cell phenotype indistinguishable from mycosis fungoides or Sezary syndrome. Immunohistochemical studies confirmed CD10 expression in seven of the eight cases and revealed the lymphoma cells were Bcl-6(+), PD-1(+), and EBV(-). Two had significant expression of CXCL-13(+). The findings indicate that lymphoma cells from mycosis fungoides or Sezary syndrome may express follicular center helper T-cell markers CD10, Bcl-6, and PD-1 and occasionally CXCL-13. The expression of these markers in some cases of mycosis fungoides/Sezary syndrome suggests follicular center helper T-cell differentiation and may lead to confusion in distinguishing mycosis fungoides/Sezary syndrome from other follicular center helper T-cell marker positive T-cell lymphomas with cutaneous manifestations.

Authors+Show Affiliations

Department of Pathology, Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH, USA. hjm2@case.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22918164

Citation

Meyerson, Howard J., et al. "Follicular Center Helper T-cell (TFH) Marker Positive Mycosis fungoides/Sezary Syndrome." Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, vol. 26, no. 1, 2013, pp. 32-43.
Meyerson HJ, Awadallah A, Pavlidakey P, et al. Follicular center helper T-cell (TFH) marker positive mycosis fungoides/Sezary syndrome. Mod Pathol. 2013;26(1):32-43.
Meyerson, H. J., Awadallah, A., Pavlidakey, P., Cooper, K., Honda, K., & Miedler, J. (2013). Follicular center helper T-cell (TFH) marker positive mycosis fungoides/Sezary syndrome. Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 26(1), pp. 32-43. doi:10.1038/modpathol.2012.124.
Meyerson HJ, et al. Follicular Center Helper T-cell (TFH) Marker Positive Mycosis fungoides/Sezary Syndrome. Mod Pathol. 2013;26(1):32-43. PubMed PMID: 22918164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Follicular center helper T-cell (TFH) marker positive mycosis fungoides/Sezary syndrome. AU - Meyerson,Howard J, AU - Awadallah,Amad, AU - Pavlidakey,Peter, AU - Cooper,Kevin, AU - Honda,Kord, AU - Miedler,John, Y1 - 2012/08/24/ PY - 2012/8/25/entrez PY - 2012/8/25/pubmed PY - 2013/7/23/medline SP - 32 EP - 43 JF - Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc JO - Mod. Pathol. VL - 26 IS - 1 N2 - We identified 11 patients with CD10(+) cutaneous T-cell lymphoma by flow cytometry. All cases were CD4(+) and CD8(-). Three patients had extensive lymphadenopathy, systemic symptoms and an aggressive clinical course consistent with angioimmunoblastic T-cell lymphoma or peripheral T-cell lymphoma. However, 8 of the 11 patients had a prolonged disease course with gross morphology, histology and tumor cell phenotype indistinguishable from mycosis fungoides or Sezary syndrome. Immunohistochemical studies confirmed CD10 expression in seven of the eight cases and revealed the lymphoma cells were Bcl-6(+), PD-1(+), and EBV(-). Two had significant expression of CXCL-13(+). The findings indicate that lymphoma cells from mycosis fungoides or Sezary syndrome may express follicular center helper T-cell markers CD10, Bcl-6, and PD-1 and occasionally CXCL-13. The expression of these markers in some cases of mycosis fungoides/Sezary syndrome suggests follicular center helper T-cell differentiation and may lead to confusion in distinguishing mycosis fungoides/Sezary syndrome from other follicular center helper T-cell marker positive T-cell lymphomas with cutaneous manifestations. SN - 1530-0285 UR - https://www.unboundmedicine.com/medline/citation/22918164/Follicular_center_helper_T_cell__TFH__marker_positive_mycosis_fungoides/Sezary_syndrome_ L2 - http://dx.doi.org/10.1038/modpathol.2012.124 DB - PRIME DP - Unbound Medicine ER -