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The Relationship between caffeine and coffee consumption and exfoliation glaucoma or glaucoma suspect: a prospective study in two cohorts.
Invest Ophthalmol Vis Sci. 2012 Sep 21; 53(10):6427-33.IO

Abstract

PURPOSE

We examined the association between caffeine and caffeinated beverage consumption in relation to the risk of exfoliation glaucoma or exfoliation glaucoma suspect (EG/EGS).

METHODS

We followed 78,977 women from the Nurses' Health Study (NHS) and 41,202 men from the Health Professionals Follow-up Study (HPFS) who were at least 40 years of age, did not have glaucoma, and reported undergoing eye examinations from 1980 (NHS) or 1986 (HPFS) to 2008. Information on consumption of caffeine-containing beverages and potential confounders were repeatedly ascertained in validated follow-up questionnaires. Confirmation with medical record review revealed 360 incident EG/EGS cases. Multivariate rate ratios (RRs) for EG/EGS were calculated in each cohort and then pooled using meta-analytic techniques.

RESULTS

Compared with participants whose cumulatively updated total caffeine consumption was <125 mg/day, participants who consumed ≥ 500 mg/day had a trend toward increased risk of EG/EGS that was not statistically significant (RR = 1.43; 95% confidence interval [CI], 0.98-2.08); P trend = 0.06). Compared to abstainers, those who drank ≥ 3 cups of caffeinated coffee daily were at increased risk of EG/EGS (RR = 1.66; 95% CI, 1.09-2.54; P trend = 0.02). These results were not materially altered after adjustment for total fluid intake. Associations were stronger among women with a family history of glaucoma (P interaction = 0.06 for coffee; P interaction = 0.03 for caffeine). We did not find associations with consumption of other caffeinated products (caffeinated soda, caffeinated tea, decaffeinated coffee or chocolate) and risk of EG/EGS (P trend ≥ 0.31).

CONCLUSIONS

We observed a positive association between heavier coffee consumption with risk of EG/EGS in this large prospective study.

Authors+Show Affiliations

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22918628

Citation

Pasquale, Louis R., et al. "The Relationship Between Caffeine and Coffee Consumption and Exfoliation Glaucoma or Glaucoma Suspect: a Prospective Study in Two Cohorts." Investigative Ophthalmology & Visual Science, vol. 53, no. 10, 2012, pp. 6427-33.
Pasquale LR, Wiggs JL, Willett WC, et al. The Relationship between caffeine and coffee consumption and exfoliation glaucoma or glaucoma suspect: a prospective study in two cohorts. Invest Ophthalmol Vis Sci. 2012;53(10):6427-33.
Pasquale, L. R., Wiggs, J. L., Willett, W. C., & Kang, J. H. (2012). The Relationship between caffeine and coffee consumption and exfoliation glaucoma or glaucoma suspect: a prospective study in two cohorts. Investigative Ophthalmology & Visual Science, 53(10), 6427-33.
Pasquale LR, et al. The Relationship Between Caffeine and Coffee Consumption and Exfoliation Glaucoma or Glaucoma Suspect: a Prospective Study in Two Cohorts. Invest Ophthalmol Vis Sci. 2012 Sep 21;53(10):6427-33. PubMed PMID: 22918628.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Relationship between caffeine and coffee consumption and exfoliation glaucoma or glaucoma suspect: a prospective study in two cohorts. AU - Pasquale,Louis R, AU - Wiggs,Janey L, AU - Willett,Walter C, AU - Kang,Jae H, Y1 - 2012/09/21/ PY - 2012/8/25/entrez PY - 2012/8/25/pubmed PY - 2012/12/12/medline SP - 6427 EP - 33 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 53 IS - 10 N2 - PURPOSE: We examined the association between caffeine and caffeinated beverage consumption in relation to the risk of exfoliation glaucoma or exfoliation glaucoma suspect (EG/EGS). METHODS: We followed 78,977 women from the Nurses' Health Study (NHS) and 41,202 men from the Health Professionals Follow-up Study (HPFS) who were at least 40 years of age, did not have glaucoma, and reported undergoing eye examinations from 1980 (NHS) or 1986 (HPFS) to 2008. Information on consumption of caffeine-containing beverages and potential confounders were repeatedly ascertained in validated follow-up questionnaires. Confirmation with medical record review revealed 360 incident EG/EGS cases. Multivariate rate ratios (RRs) for EG/EGS were calculated in each cohort and then pooled using meta-analytic techniques. RESULTS: Compared with participants whose cumulatively updated total caffeine consumption was <125 mg/day, participants who consumed ≥ 500 mg/day had a trend toward increased risk of EG/EGS that was not statistically significant (RR = 1.43; 95% confidence interval [CI], 0.98-2.08); P trend = 0.06). Compared to abstainers, those who drank ≥ 3 cups of caffeinated coffee daily were at increased risk of EG/EGS (RR = 1.66; 95% CI, 1.09-2.54; P trend = 0.02). These results were not materially altered after adjustment for total fluid intake. Associations were stronger among women with a family history of glaucoma (P interaction = 0.06 for coffee; P interaction = 0.03 for caffeine). We did not find associations with consumption of other caffeinated products (caffeinated soda, caffeinated tea, decaffeinated coffee or chocolate) and risk of EG/EGS (P trend ≥ 0.31). CONCLUSIONS: We observed a positive association between heavier coffee consumption with risk of EG/EGS in this large prospective study. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/22918628/The_Relationship_between_caffeine_and_coffee_consumption_and_exfoliation_glaucoma_or_glaucoma_suspect:_a_prospective_study_in_two_cohorts_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.12-10085 DB - PRIME DP - Unbound Medicine ER -