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Indomethacin for post-endoscopic retrograde cholangiopancreatography pancreatitis prophylaxis: is it the magic bullet?
World J Gastroenterol. 2012 Aug 21; 18(31):4082-5.WJ

Abstract

Acute pancreatitis is a common complication of endoscopic retrograde cholangiopancreatography (ERCP). Pancreatic duct stent insertion after ERCP has been widely accepted as the standard of care for the prevention of this complication in high-risk patients. Unfortunately, the placement of pancreatic stents requires higher level of endoscopic expertise and is not always feasible due to anatomic considerations. Therefore, effective non-invasive pharmacologic prophylaxis remains appealing, particularly if it is inexpensive, easily administered, has a low risk side effect profile and is widely available. There have been multiple studies evaluating potential pharmacologic candidates for post-ERCP pancreatitis (PEP) prophylaxis, most of them yielding disappointing results. A recently published large, multi-center, randomized controlled trial reported that in high risk patients a single dose of rectal indomethacin administered immediately after the ERCP significantly decreased the incidence of PEP compare to placebo.

Authors+Show Affiliations

Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Florida, Gainesville, FL 32610, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22919238

Citation

Yang, Dennis, and Peter V. Draganov. "Indomethacin for Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis Prophylaxis: Is It the Magic Bullet?" World Journal of Gastroenterology, vol. 18, no. 31, 2012, pp. 4082-5.
Yang D, Draganov PV. Indomethacin for post-endoscopic retrograde cholangiopancreatography pancreatitis prophylaxis: is it the magic bullet? World J Gastroenterol. 2012;18(31):4082-5.
Yang, D., & Draganov, P. V. (2012). Indomethacin for post-endoscopic retrograde cholangiopancreatography pancreatitis prophylaxis: is it the magic bullet? World Journal of Gastroenterology, 18(31), 4082-5. https://doi.org/10.3748/wjg.v18.i31.4082
Yang D, Draganov PV. Indomethacin for Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis Prophylaxis: Is It the Magic Bullet. World J Gastroenterol. 2012 Aug 21;18(31):4082-5. PubMed PMID: 22919238.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Indomethacin for post-endoscopic retrograde cholangiopancreatography pancreatitis prophylaxis: is it the magic bullet? AU - Yang,Dennis, AU - Draganov,Peter V, PY - 2012/06/20/received PY - 2012/07/10/revised PY - 2012/07/18/accepted PY - 2012/8/25/entrez PY - 2012/8/25/pubmed PY - 2013/4/5/medline KW - Acute pancreatitis KW - Indomethacin KW - Non-steroidal anti-inflammatory drugs KW - Post-endoscopic retrograde cholangiopancreatography pancreatitis SP - 4082 EP - 5 JF - World journal of gastroenterology JO - World J Gastroenterol VL - 18 IS - 31 N2 - Acute pancreatitis is a common complication of endoscopic retrograde cholangiopancreatography (ERCP). Pancreatic duct stent insertion after ERCP has been widely accepted as the standard of care for the prevention of this complication in high-risk patients. Unfortunately, the placement of pancreatic stents requires higher level of endoscopic expertise and is not always feasible due to anatomic considerations. Therefore, effective non-invasive pharmacologic prophylaxis remains appealing, particularly if it is inexpensive, easily administered, has a low risk side effect profile and is widely available. There have been multiple studies evaluating potential pharmacologic candidates for post-ERCP pancreatitis (PEP) prophylaxis, most of them yielding disappointing results. A recently published large, multi-center, randomized controlled trial reported that in high risk patients a single dose of rectal indomethacin administered immediately after the ERCP significantly decreased the incidence of PEP compare to placebo. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/22919238/Indomethacin_for_post_endoscopic_retrograde_cholangiopancreatography_pancreatitis_prophylaxis:_is_it_the_magic_bullet L2 - https://www.wjgnet.com/1007-9327/full/v18/i31/4082.htm DB - PRIME DP - Unbound Medicine ER -