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Metabolic syndrome and gallstone disease.

Abstract

AIM

To investigate the association between metabolic syndrome (MetS) and the development of gallstone disease (GSD).

METHODS

A cross-sectional study was conducted in 7570 subjects (4978 men aged 45.0 ± 8.8 years, and 2592 women aged 45.3 ± 9.5 years) enrolled from the physical check-up center of the hospital. The subjects included 918 patients with gallstones (653 men and 265 women) and 6652 healthy controls (4325 men and 2327 women) without gallstones. Body mass index (BMI), waist circumference, blood pressure, fasting plasma glucose (FPG) and serum lipids and lipoproteins levels were measured. Colorimetric method was used to measure cholesterol, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). Dextrose oxidizing enzyme method was used to measure FPG. Subjects were asked to complete a questionnaire that enquired about the information on demographic data, age, gender, histories of diabetes mellitus, hypertension, and chronic liver disease and so on. Metabolic syndrome was diagnosed according to the Adult Treatment Panel III (ATP III) criteria. Gallstones were defined by the presence of strong intraluminal echoes that were gravity-dependent or attenuated ultrasound transmission.

RESULTS

Among the 7570 subjects, the prevalence of the gallstone disease was 12.1% (13.1% in men and 10.2% in women). BMI, waist circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose and serum triglyceride (TG) in cases group were higher than in controls, while serum high-density lipid was lower than in controls. There were significant differences in the waist circumference, blood pressure, FPG and TG between cases and controls. In an age-adjusted logistic regression model, metabolic syndrome was associated with gallstone disease. The age-adjusted odds ratio of MetS for GSD in men was 1.29 [95% confidence interval (CI), 1.09-1.52; P = 0.0030], and 1.68 (95% CI, 1.26-2.25; P = 0.0004) in women; the overall age-adjusted odds ratio of MetS for GSD was 1.42 (95% CI, 1.23-1.64; P < 0.0001). The men with more metabolic disorders had a higher prevalence of gallstone disease, the trend had statistical significance (P < 0.0001). The presence of 5 components of the MetS increased the risk of gallstone disease by 3.4 times (P < 0.0001). The prevalence of GSD in women who had 5 components of MetS was 5 times higher than in those without MetS component. The more the components of MetS, the higher the prevalence of GSD (P < 0.0001). The presence of 5 components of the MetS increased the risk of gallstone disease by 4.0 times.

CONCLUSION

GSD appears to be strongly associated with MetS, and the more the components of MetS, the higher the prevalence of GSD.

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  • Authors+Show Affiliations

    ,

    Department of Family Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, Zhejiang Province, China.

    , , , ,

    Source

    World journal of gastroenterology 18:31 2012 Aug 21 pg 4215-20

    MeSH

    Adult
    Blood Glucose
    Blood Pressure
    Body Mass Index
    Case-Control Studies
    Cross-Sectional Studies
    Female
    Gallstones
    Humans
    Lipids
    Logistic Models
    Male
    Metabolic Syndrome
    Middle Aged
    Prevalence
    Risk Factors
    Waist Circumference

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22919256

    Citation

    Chen, Li-Ying, et al. "Metabolic Syndrome and Gallstone Disease." World Journal of Gastroenterology, vol. 18, no. 31, 2012, pp. 4215-20.
    Chen LY, Qiao QH, Zhang SC, et al. Metabolic syndrome and gallstone disease. World J Gastroenterol. 2012;18(31):4215-20.
    Chen, L. Y., Qiao, Q. H., Zhang, S. C., Chen, Y. H., Chao, G. Q., & Fang, L. Z. (2012). Metabolic syndrome and gallstone disease. World Journal of Gastroenterology, 18(31), pp. 4215-20. doi:10.3748/wjg.v18.i31.4215.
    Chen LY, et al. Metabolic Syndrome and Gallstone Disease. World J Gastroenterol. 2012 Aug 21;18(31):4215-20. PubMed PMID: 22919256.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Metabolic syndrome and gallstone disease. AU - Chen,Li-Ying, AU - Qiao,Qiao-Hua, AU - Zhang,Shan-Chun, AU - Chen,Yu-Hao, AU - Chao,Guan-Qun, AU - Fang,Li-Zheng, PY - 2012/02/25/received PY - 2012/05/18/revised PY - 2012/05/26/accepted PY - 2012/8/25/entrez PY - 2012/8/25/pubmed PY - 2013/4/5/medline KW - Dyslipidemia KW - Gallstone disease KW - Hypertension KW - Metabolic syndrome KW - Obesity SP - 4215 EP - 20 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 18 IS - 31 N2 - AIM: To investigate the association between metabolic syndrome (MetS) and the development of gallstone disease (GSD). METHODS: A cross-sectional study was conducted in 7570 subjects (4978 men aged 45.0 ± 8.8 years, and 2592 women aged 45.3 ± 9.5 years) enrolled from the physical check-up center of the hospital. The subjects included 918 patients with gallstones (653 men and 265 women) and 6652 healthy controls (4325 men and 2327 women) without gallstones. Body mass index (BMI), waist circumference, blood pressure, fasting plasma glucose (FPG) and serum lipids and lipoproteins levels were measured. Colorimetric method was used to measure cholesterol, high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). Dextrose oxidizing enzyme method was used to measure FPG. Subjects were asked to complete a questionnaire that enquired about the information on demographic data, age, gender, histories of diabetes mellitus, hypertension, and chronic liver disease and so on. Metabolic syndrome was diagnosed according to the Adult Treatment Panel III (ATP III) criteria. Gallstones were defined by the presence of strong intraluminal echoes that were gravity-dependent or attenuated ultrasound transmission. RESULTS: Among the 7570 subjects, the prevalence of the gallstone disease was 12.1% (13.1% in men and 10.2% in women). BMI, waist circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose and serum triglyceride (TG) in cases group were higher than in controls, while serum high-density lipid was lower than in controls. There were significant differences in the waist circumference, blood pressure, FPG and TG between cases and controls. In an age-adjusted logistic regression model, metabolic syndrome was associated with gallstone disease. The age-adjusted odds ratio of MetS for GSD in men was 1.29 [95% confidence interval (CI), 1.09-1.52; P = 0.0030], and 1.68 (95% CI, 1.26-2.25; P = 0.0004) in women; the overall age-adjusted odds ratio of MetS for GSD was 1.42 (95% CI, 1.23-1.64; P < 0.0001). The men with more metabolic disorders had a higher prevalence of gallstone disease, the trend had statistical significance (P < 0.0001). The presence of 5 components of the MetS increased the risk of gallstone disease by 3.4 times (P < 0.0001). The prevalence of GSD in women who had 5 components of MetS was 5 times higher than in those without MetS component. The more the components of MetS, the higher the prevalence of GSD (P < 0.0001). The presence of 5 components of the MetS increased the risk of gallstone disease by 4.0 times. CONCLUSION: GSD appears to be strongly associated with MetS, and the more the components of MetS, the higher the prevalence of GSD. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/22919256/Metabolic_syndrome_and_gallstone_disease_ L2 - http://www.wjgnet.com/1007-9327/full/v18/i31/4215.htm DB - PRIME DP - Unbound Medicine ER -