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In vitro evaluation of antiprotozoal and antiviral activities of extracts from Argentinean Mikania species.
ScientificWorldJournal. 2012; 2012:121253.S

Abstract

The aim of this study was to investigate the antiprotozoal and antiviral activities of four Argentinean Mikania species. The organic and aqueous extracts of Mikania micrantha, M. parodii, M. periplocifolia, and M. cordifolia were tested on Trypanosoma cruzi epimastigotes, Leishmania braziliensis promastigotes, and dengue virus type 2. The organic extract of M. micrantha was the most active against T. cruzi and L. braziliensis exhibiting a growth inhibition of 77.6 ± 4.5% and 84.9 ± 6.1%, respectively, at a concentration of 10 μg/ml. The bioguided fractionation of M. micrantha organic extract led to the identification of two active fractions. The chromatographic profile and infrared analysis of these fractions revealed the presence of sesquiterpene lactones. None of the tested extracts were active against dengue virus type 2.

Authors+Show Affiliations

Cátedra de Farmacognosia, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 2°P, 1113, Buenos Aires, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22919289

Citation

Laurella, Laura C., et al. "In Vitro Evaluation of Antiprotozoal and Antiviral Activities of Extracts From Argentinean Mikania Species." TheScientificWorldJournal, vol. 2012, 2012, p. 121253.
Laurella LC, Frank FM, Sarquiz A, et al. In vitro evaluation of antiprotozoal and antiviral activities of extracts from Argentinean Mikania species. ScientificWorldJournal. 2012;2012:121253.
Laurella, L. C., Frank, F. M., Sarquiz, A., Alonso, M. R., Giberti, G., Cavallaro, L., Catalán, C. A., Cazorla, S. I., Malchiodi, E., Martino, V. S., & Sülsen, V. P. (2012). In vitro evaluation of antiprotozoal and antiviral activities of extracts from Argentinean Mikania species. TheScientificWorldJournal, 2012, 121253. https://doi.org/10.1100/2012/121253
Laurella LC, et al. In Vitro Evaluation of Antiprotozoal and Antiviral Activities of Extracts From Argentinean Mikania Species. ScientificWorldJournal. 2012;2012:121253. PubMed PMID: 22919289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro evaluation of antiprotozoal and antiviral activities of extracts from Argentinean Mikania species. AU - Laurella,Laura C, AU - Frank,Fernanda M, AU - Sarquiz,Andrea, AU - Alonso,María R, AU - Giberti,Gustavo, AU - Cavallaro,Lucia, AU - Catalán,Cesar A, AU - Cazorla,Silvia I, AU - Malchiodi,Emilio, AU - Martino,Virginia S, AU - Sülsen,Valeria P, Y1 - 2012/07/31/ PY - 2012/05/18/received PY - 2012/06/05/accepted PY - 2012/8/25/entrez PY - 2012/8/25/pubmed PY - 2013/3/13/medline SP - 121253 EP - 121253 JF - TheScientificWorldJournal JO - ScientificWorldJournal VL - 2012 N2 - The aim of this study was to investigate the antiprotozoal and antiviral activities of four Argentinean Mikania species. The organic and aqueous extracts of Mikania micrantha, M. parodii, M. periplocifolia, and M. cordifolia were tested on Trypanosoma cruzi epimastigotes, Leishmania braziliensis promastigotes, and dengue virus type 2. The organic extract of M. micrantha was the most active against T. cruzi and L. braziliensis exhibiting a growth inhibition of 77.6 ± 4.5% and 84.9 ± 6.1%, respectively, at a concentration of 10 μg/ml. The bioguided fractionation of M. micrantha organic extract led to the identification of two active fractions. The chromatographic profile and infrared analysis of these fractions revealed the presence of sesquiterpene lactones. None of the tested extracts were active against dengue virus type 2. SN - 1537-744X UR - https://www.unboundmedicine.com/medline/citation/22919289/In_vitro_evaluation_of_antiprotozoal_and_antiviral_activities_of_extracts_from_Argentinean_Mikania_species_ L2 - https://dx.doi.org/10.1100/2012/121253 DB - PRIME DP - Unbound Medicine ER -