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Comprehensive review on oral disintegrating films.
Curr Drug Deliv. 2013 Feb; 10(1):96-108.CD

Abstract

Fast-dissolving drug-delivery systems were first developed in the late 1970s as an alternative to tablets, capsules, and syrups for pediatric and geriatric patients who experience difficulties swallowing traditional oral solid dosage forms. In response to this need, a variety of orally disintegrating tablet (ODT) formats were commercialized, which disintegrate within 1 min when placed in the mouth without drinking water or chewing. Oral drug delivery technology has improved from conventional dosage forms to modified release dosage forms to ODT to the recent oral disintegrating films (ODF). Oral disintegrating film or strip that employs a water dissolving polymer which allows the dosage form to quickly hydrate by saliva, adhere to mucosa, and disintegrate within a few seconds, dissolve and releases medication for oromucosal absorption when placed on the tongue or oral cavity. Oral strip technology provides an alternate route for drugs with first pass metabolism. This review give details of materials used in ODF, manufacturing aspects, technologies, evaluation tests and marketed products.

Authors+Show Affiliations

Department of Pharmaceutics, Vaagdevi College of Pharmacy, Warangal, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22920576

Citation

Nagaraju, T, et al. "Comprehensive Review On Oral Disintegrating Films." Current Drug Delivery, vol. 10, no. 1, 2013, pp. 96-108.
Nagaraju T, Gowthami R, Rajashekar M, et al. Comprehensive review on oral disintegrating films. Curr Drug Deliv. 2013;10(1):96-108.
Nagaraju, T., Gowthami, R., Rajashekar, M., Sandeep, S., Mallesham, M., Sathish, D., & Kumar, Y. S. (2013). Comprehensive review on oral disintegrating films. Current Drug Delivery, 10(1), 96-108.
Nagaraju T, et al. Comprehensive Review On Oral Disintegrating Films. Curr Drug Deliv. 2013;10(1):96-108. PubMed PMID: 22920576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comprehensive review on oral disintegrating films. AU - Nagaraju,T, AU - Gowthami,R, AU - Rajashekar,M, AU - Sandeep,S, AU - Mallesham,M, AU - Sathish,D, AU - Kumar,Y Shravan, PY - 2011/04/21/received PY - 2011/06/25/revised PY - 2011/10/17/accepted PY - 2012/8/28/entrez PY - 2012/8/28/pubmed PY - 2013/8/27/medline SP - 96 EP - 108 JF - Current drug delivery JO - Curr Drug Deliv VL - 10 IS - 1 N2 - Fast-dissolving drug-delivery systems were first developed in the late 1970s as an alternative to tablets, capsules, and syrups for pediatric and geriatric patients who experience difficulties swallowing traditional oral solid dosage forms. In response to this need, a variety of orally disintegrating tablet (ODT) formats were commercialized, which disintegrate within 1 min when placed in the mouth without drinking water or chewing. Oral drug delivery technology has improved from conventional dosage forms to modified release dosage forms to ODT to the recent oral disintegrating films (ODF). Oral disintegrating film or strip that employs a water dissolving polymer which allows the dosage form to quickly hydrate by saliva, adhere to mucosa, and disintegrate within a few seconds, dissolve and releases medication for oromucosal absorption when placed on the tongue or oral cavity. Oral strip technology provides an alternate route for drugs with first pass metabolism. This review give details of materials used in ODF, manufacturing aspects, technologies, evaluation tests and marketed products. SN - 1875-5704 UR - https://www.unboundmedicine.com/medline/citation/22920576/Comprehensive_review_on_oral_disintegrating_films_ L2 - http://www.eurekaselect.com/107659/article DB - PRIME DP - Unbound Medicine ER -