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Comparison of vitrectomy with brilliant blue G or indocyanine green on retinal microstructure and function of eyes with macular hole.
Ophthalmology. 2012 Dec; 119(12):2609-15.O

Abstract

PURPOSE

To evaluate the microstructure of the inner and outer retina and the visual function after macular hole (MH) surgery using brilliant blue G (BBG) or indocyanine green (ICG) to make the internal limiting membrane (ILM) more visible.

DESIGN

Comparative, retrospective, interventional case series.

PARTICIPANTS

Sixty-three eyes of 63 consecutive cases with MH were studied. Thirty-five eyes of 35 cases were treated with BBG between January and August 2011. Twenty-eight eyes of 28 MH cases were treated with ICG from April 2009 through April 2010.

METHODS

Vitrectomy was performed with a 23-gauge system and 0.25 mg/ml BBG or with 0.125% ICG.

MAIN OUTCOME MEASURES

The best-corrected visual acuity (BCVA) and the microperimetry-determined retinal sensitivity were measured at baseline and at 3 and 6 months after surgery. The length of the defect of the photoreceptor inner segment/outer segment (IS/OS) junction and external limiting membrane (ELM), the central foveal thickness (CFT), and the thickness of the ganglion cell complex (GCC) were measured in the spectral-domain optical coherence tomographic images.

RESULTS

The average BCVA was significantly better in the BBG group than in the ICG group at 3 months (P = 0.021) and 6 months (P = 0.045) after surgery. The mean retinal sensitivity in the BBG group was improved significantly in the central 2° at 3 and 6 months (P = 0.001 and P = 0.030, respectively), but was not significantly improved in the adjacent 10°. The length of IS/OS junction defect was significantly shorter in the BBG group at 3 months (P = 0.048), but was not significantly different at 6 months (P = 0.135). The length of ELM defect and the GCC thickness were not significantly different between the 2 groups at 3 and 6 months. The CFT was significantly thinner in the ICG group than in the BBG group at 3 and 6 months (P = 0.013 and P = 0.001, respectively).

CONCLUSIONS

The postoperative BCVA and retinal sensitivity in the central 2° were better in eyes after BBG-assisted vitrectomy. The restoration of IS/OS junction was faster in the BBG group, and the CFT was significantly thinner in eyes after ICG. Brilliant blue G may be a better agent than ICG to make the ILM more visible.

FINANCIAL DISCLOSURE(S)

The author(s) have no proprietary or commercial interest in any materials discussed in this article.

Authors+Show Affiliations

Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan. babatakayuki@nifty.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22921387

Citation

Baba, Takayuki, et al. "Comparison of Vitrectomy With Brilliant Blue G or Indocyanine Green On Retinal Microstructure and Function of Eyes With Macular Hole." Ophthalmology, vol. 119, no. 12, 2012, pp. 2609-15.
Baba T, Hagiwara A, Sato E, et al. Comparison of vitrectomy with brilliant blue G or indocyanine green on retinal microstructure and function of eyes with macular hole. Ophthalmology. 2012;119(12):2609-15.
Baba, T., Hagiwara, A., Sato, E., Arai, M., Oshitari, T., & Yamamoto, S. (2012). Comparison of vitrectomy with brilliant blue G or indocyanine green on retinal microstructure and function of eyes with macular hole. Ophthalmology, 119(12), 2609-15. https://doi.org/10.1016/j.ophtha.2012.06.048
Baba T, et al. Comparison of Vitrectomy With Brilliant Blue G or Indocyanine Green On Retinal Microstructure and Function of Eyes With Macular Hole. Ophthalmology. 2012;119(12):2609-15. PubMed PMID: 22921387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of vitrectomy with brilliant blue G or indocyanine green on retinal microstructure and function of eyes with macular hole. AU - Baba,Takayuki, AU - Hagiwara,Akira, AU - Sato,Eiju, AU - Arai,Miyuki, AU - Oshitari,Toshiyuki, AU - Yamamoto,Shuichi, Y1 - 2012/08/24/ PY - 2012/03/20/received PY - 2012/06/27/revised PY - 2012/06/27/accepted PY - 2012/8/28/entrez PY - 2012/8/28/pubmed PY - 2013/2/8/medline SP - 2609 EP - 15 JF - Ophthalmology JO - Ophthalmology VL - 119 IS - 12 N2 - PURPOSE: To evaluate the microstructure of the inner and outer retina and the visual function after macular hole (MH) surgery using brilliant blue G (BBG) or indocyanine green (ICG) to make the internal limiting membrane (ILM) more visible. DESIGN: Comparative, retrospective, interventional case series. PARTICIPANTS: Sixty-three eyes of 63 consecutive cases with MH were studied. Thirty-five eyes of 35 cases were treated with BBG between January and August 2011. Twenty-eight eyes of 28 MH cases were treated with ICG from April 2009 through April 2010. METHODS: Vitrectomy was performed with a 23-gauge system and 0.25 mg/ml BBG or with 0.125% ICG. MAIN OUTCOME MEASURES: The best-corrected visual acuity (BCVA) and the microperimetry-determined retinal sensitivity were measured at baseline and at 3 and 6 months after surgery. The length of the defect of the photoreceptor inner segment/outer segment (IS/OS) junction and external limiting membrane (ELM), the central foveal thickness (CFT), and the thickness of the ganglion cell complex (GCC) were measured in the spectral-domain optical coherence tomographic images. RESULTS: The average BCVA was significantly better in the BBG group than in the ICG group at 3 months (P = 0.021) and 6 months (P = 0.045) after surgery. The mean retinal sensitivity in the BBG group was improved significantly in the central 2° at 3 and 6 months (P = 0.001 and P = 0.030, respectively), but was not significantly improved in the adjacent 10°. The length of IS/OS junction defect was significantly shorter in the BBG group at 3 months (P = 0.048), but was not significantly different at 6 months (P = 0.135). The length of ELM defect and the GCC thickness were not significantly different between the 2 groups at 3 and 6 months. The CFT was significantly thinner in the ICG group than in the BBG group at 3 and 6 months (P = 0.013 and P = 0.001, respectively). CONCLUSIONS: The postoperative BCVA and retinal sensitivity in the central 2° were better in eyes after BBG-assisted vitrectomy. The restoration of IS/OS junction was faster in the BBG group, and the CFT was significantly thinner in eyes after ICG. Brilliant blue G may be a better agent than ICG to make the ILM more visible. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/22921387/Comparison_of_vitrectomy_with_brilliant_blue_G_or_indocyanine_green_on_retinal_microstructure_and_function_of_eyes_with_macular_hole_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(12)00608-2 DB - PRIME DP - Unbound Medicine ER -