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The dose effects of short-term dronabinol (oral THC) maintenance in daily cannabis users.
Drug Alcohol Depend. 2013 Feb 01; 128(1-2):64-70.DA

Abstract

BACKGROUND

Prior studies have separately examined the effects of dronabinol (oral THC) on cannabis withdrawal, cognitive performance, and the acute effects of smoked cannabis. A single study examining these clinically relevant domains would benefit the continued evaluation of dronabinol as a potential medication for the treatment of cannabis use disorders.

METHODS

Thirteen daily cannabis smokers completed a within-subject crossover study and received 0, 30, 60 and 120mg dronabinol per day for 5 consecutive days. Vital signs and subjective ratings of cannabis withdrawal, craving and sleep were obtained daily; outcomes under active dose conditions were compared to those obtained under placebo dosing. On the 5th day of medication maintenance, participants completed a comprehensive cognitive performance battery and then smoked five puffs of cannabis for subjective effects evaluation. Each dronabinol maintenance period occurred in a counterbalanced order and was separated by 9 days of ad libitum cannabis use.

RESULTS

Dronabinol dose-dependently attenuated cannabis withdrawal and resulted in few adverse side effects or decrements in cognitive performance. Surprisingly, dronabinol did not alter the subjective effects of smoked cannabis, but cannabis-induced increases in heart rate were attenuated by the 60 and 120mg doses.

CONCLUSIONS

Dronabinol's ability to dose-dependently suppress cannabis withdrawal may be therapeutically beneficial to individuals trying to stop cannabis use. The absence of gross cognitive impairment or side effects in this study supports safety of doses up to 120mg/day. Continued evaluation of dronabinol in targeted clinical studies of cannabis treatment, using an expanded range of doses, is warranted.

Authors+Show Affiliations

Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA. rvandrey@jhmi.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22921474

Citation

Vandrey, Ryan, et al. "The Dose Effects of Short-term Dronabinol (oral THC) Maintenance in Daily Cannabis Users." Drug and Alcohol Dependence, vol. 128, no. 1-2, 2013, pp. 64-70.
Vandrey R, Stitzer ML, Mintzer MZ, et al. The dose effects of short-term dronabinol (oral THC) maintenance in daily cannabis users. Drug Alcohol Depend. 2013;128(1-2):64-70.
Vandrey, R., Stitzer, M. L., Mintzer, M. Z., Huestis, M. A., Murray, J. A., & Lee, D. (2013). The dose effects of short-term dronabinol (oral THC) maintenance in daily cannabis users. Drug and Alcohol Dependence, 128(1-2), 64-70. https://doi.org/10.1016/j.drugalcdep.2012.08.001
Vandrey R, et al. The Dose Effects of Short-term Dronabinol (oral THC) Maintenance in Daily Cannabis Users. Drug Alcohol Depend. 2013 Feb 1;128(1-2):64-70. PubMed PMID: 22921474.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The dose effects of short-term dronabinol (oral THC) maintenance in daily cannabis users. AU - Vandrey,Ryan, AU - Stitzer,Maxine L, AU - Mintzer,Miriam Z, AU - Huestis,Marilyn A, AU - Murray,Jeannie A, AU - Lee,Dayong, Y1 - 2012/08/22/ PY - 2012/05/07/received PY - 2012/07/19/revised PY - 2012/08/01/accepted PY - 2012/8/28/entrez PY - 2012/8/28/pubmed PY - 2013/6/25/medline SP - 64 EP - 70 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 128 IS - 1-2 N2 - BACKGROUND: Prior studies have separately examined the effects of dronabinol (oral THC) on cannabis withdrawal, cognitive performance, and the acute effects of smoked cannabis. A single study examining these clinically relevant domains would benefit the continued evaluation of dronabinol as a potential medication for the treatment of cannabis use disorders. METHODS: Thirteen daily cannabis smokers completed a within-subject crossover study and received 0, 30, 60 and 120mg dronabinol per day for 5 consecutive days. Vital signs and subjective ratings of cannabis withdrawal, craving and sleep were obtained daily; outcomes under active dose conditions were compared to those obtained under placebo dosing. On the 5th day of medication maintenance, participants completed a comprehensive cognitive performance battery and then smoked five puffs of cannabis for subjective effects evaluation. Each dronabinol maintenance period occurred in a counterbalanced order and was separated by 9 days of ad libitum cannabis use. RESULTS: Dronabinol dose-dependently attenuated cannabis withdrawal and resulted in few adverse side effects or decrements in cognitive performance. Surprisingly, dronabinol did not alter the subjective effects of smoked cannabis, but cannabis-induced increases in heart rate were attenuated by the 60 and 120mg doses. CONCLUSIONS: Dronabinol's ability to dose-dependently suppress cannabis withdrawal may be therapeutically beneficial to individuals trying to stop cannabis use. The absence of gross cognitive impairment or side effects in this study supports safety of doses up to 120mg/day. Continued evaluation of dronabinol in targeted clinical studies of cannabis treatment, using an expanded range of doses, is warranted. SN - 1879-0046 UR - https://www.unboundmedicine.com/medline/citation/22921474/The_dose_effects_of_short_term_dronabinol__oral_THC__maintenance_in_daily_cannabis_users_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(12)00292-X DB - PRIME DP - Unbound Medicine ER -