Tags

Type your tag names separated by a space and hit enter

Oxidative stress and antioxidant capacity in patients with chronic pancreatitis with and without diabetes mellitus.
Indian J Gastroenterol. 2012 Sep; 31(5):226-31.IJ

Abstract

AIM

To determine oxidant stress and antioxidant capacity in chronic pancreatitis (CP) patients with and without diabetes mellitus.

METHODS

This study is a secondary data analysis of our earlier study on 127 (male = 86) patients with CP, grouped as those with diabetes (case; n = 23) and those without diabetes (control). Markers of antioxidant status included vitamins A and E, total antioxidant capacity (TAC; measured as ferric-reducing ability of plasma [FRAP]), and total glutathione (T-GSH). Markers for oxidative stress included lipid peroxidation, measured as thiobarbituric acid reactive substances (TBARS) and serum superoxide dismutase (s-SOD).

RESULTS

Patients with diabetes were older (mean [SD] age 36.4 [9.7] vs. 29.3 [10.0] years; p = 0.032), had longer duration of CP [4 (0.3-21) vs. 3 (0.3-24) years; p = 0.07), and had a lower TAC (269.8 [92.4] vs. 355.5 [128.6] μmoles Fe(+2) liberated; p = 0.003) compared to those without diabetes. In multiple logistic regression analysis taking all exploratory variables, FRAP (<270 μmoles Fe(+2) liberated) was associated with diabetes independent of duration of CP, age of patients, and TBARS levels. However, oxidative stress levels were not different between diabetic and nondiabetic patients.

CONCLUSIONS

Diabetes was found to be associated with longer duration of CP and with low antioxidant capacity. Further studies will be needed to evaluate a causal association.

Authors+Show Affiliations

Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, 110 029, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22923278

Citation

Singh, Namrata, et al. "Oxidative Stress and Antioxidant Capacity in Patients With Chronic Pancreatitis With and Without Diabetes Mellitus." Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology, vol. 31, no. 5, 2012, pp. 226-31.
Singh N, Bhardwaj P, Pandey RM, et al. Oxidative stress and antioxidant capacity in patients with chronic pancreatitis with and without diabetes mellitus. Indian J Gastroenterol. 2012;31(5):226-31.
Singh, N., Bhardwaj, P., Pandey, R. M., & Saraya, A. (2012). Oxidative stress and antioxidant capacity in patients with chronic pancreatitis with and without diabetes mellitus. Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology, 31(5), 226-31. https://doi.org/10.1007/s12664-012-0236-7
Singh N, et al. Oxidative Stress and Antioxidant Capacity in Patients With Chronic Pancreatitis With and Without Diabetes Mellitus. Indian J Gastroenterol. 2012;31(5):226-31. PubMed PMID: 22923278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress and antioxidant capacity in patients with chronic pancreatitis with and without diabetes mellitus. AU - Singh,Namrata, AU - Bhardwaj,Payal, AU - Pandey,Ravinder M, AU - Saraya,Anoop, Y1 - 2012/08/25/ PY - 2011/03/24/received PY - 2012/07/18/accepted PY - 2012/8/28/entrez PY - 2012/8/28/pubmed PY - 2013/11/20/medline SP - 226 EP - 31 JF - Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology JO - Indian J Gastroenterol VL - 31 IS - 5 N2 - AIM: To determine oxidant stress and antioxidant capacity in chronic pancreatitis (CP) patients with and without diabetes mellitus. METHODS: This study is a secondary data analysis of our earlier study on 127 (male = 86) patients with CP, grouped as those with diabetes (case; n = 23) and those without diabetes (control). Markers of antioxidant status included vitamins A and E, total antioxidant capacity (TAC; measured as ferric-reducing ability of plasma [FRAP]), and total glutathione (T-GSH). Markers for oxidative stress included lipid peroxidation, measured as thiobarbituric acid reactive substances (TBARS) and serum superoxide dismutase (s-SOD). RESULTS: Patients with diabetes were older (mean [SD] age 36.4 [9.7] vs. 29.3 [10.0] years; p = 0.032), had longer duration of CP [4 (0.3-21) vs. 3 (0.3-24) years; p = 0.07), and had a lower TAC (269.8 [92.4] vs. 355.5 [128.6] μmoles Fe(+2) liberated; p = 0.003) compared to those without diabetes. In multiple logistic regression analysis taking all exploratory variables, FRAP (<270 μmoles Fe(+2) liberated) was associated with diabetes independent of duration of CP, age of patients, and TBARS levels. However, oxidative stress levels were not different between diabetic and nondiabetic patients. CONCLUSIONS: Diabetes was found to be associated with longer duration of CP and with low antioxidant capacity. Further studies will be needed to evaluate a causal association. SN - 0975-0711 UR - https://www.unboundmedicine.com/medline/citation/22923278/Oxidative_stress_and_antioxidant_capacity_in_patients_with_chronic_pancreatitis_with_and_without_diabetes_mellitus_ L2 - https://dx.doi.org/10.1007/s12664-012-0236-7 DB - PRIME DP - Unbound Medicine ER -