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Factors associated with adherence to highly active antiretroviral therapy among children in two referral hospitals, northwest Ethiopia.
Ethiop Med J. 2012 Apr; 50(2):115-24.EM

Abstract

BACKGROUND

highly active antiretroviral therapy (HAART) results in improved survival, clinical, immunological and virological response for children. Adherence to HAART is one of the very important factors which determine treatment success and occurrence of viral resistance. The need for near perfect adherence to lifelong antiretroviral therapy (ART) during childhood is a major challenge in the administration of HAART to HIV infected children.

OBJECTIVE

the study was aimed to determine the level of adherence and factors associated with adherence to HAART among children in Felege Hiwot and Gondar University referral hospitals.

METHODS

institution based cross-sectional study was conducted on 204 children in the paediatric ART clinics of Gondar University and Felege Hiwot hospitals. Sample size was determined by single population proportion formula and all children on ART for > or = 1 month and coming to the clinic during the data collection period were studied Ethical clearance was obtained from the Institutional Review Board of the University of Gondar. Data were collected by four nurses from the caregivers and patient charts using a pretested and structured questionnaire after informed consent. Descriptive statistics were calculated to describe study population and medical characteristics of participants while binary and multiple logistic regression analyses were used to determine the effect of factors on the outcome variable.

RESULTS

The study included 204 children (123 from Flege Hiwot and 81 from Gondar). One hundred and seven (52.4%) were males and 97(47.6%) were females. Majority (82.4%) of caregivers were females. Thirty days optimum (> or = 95%) adherence rate was 80.9% for children. Adherence counseling before initiation (OR=4.37, 95%CI 1.17 - 16.37), caregiver formal education, (OR=4.85, 95%CI 1.89 - 12.39) and caregiver's ability to identify ARV drug correctly (OR = 8.61, 95%CI 2.59-28.68) were positively associated while care giver substance use (OR=0.31, 95%CI 0.10 - 0.93) was negatively associated with adherence as compared to their counter parts.

CONCLUSION

optimum adherence rate to HAART in the study population was lower than the recommended Adherence counseling, caregiver education, substance use by caregiver, identification of ARVs determined adherence to HAART of children. Adherence assessment and counseling efforts should be continually integrated with ART for children and their caregivers.

Authors+Show Affiliations

University of Gondar, Gondar Ethiopia.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22924280

Citation

Azmeraw, Daniel, and Belaynew Wasie. "Factors Associated With Adherence to Highly Active Antiretroviral Therapy Among Children in Two Referral Hospitals, Northwest Ethiopia." Ethiopian Medical Journal, vol. 50, no. 2, 2012, pp. 115-24.
Azmeraw D, Wasie B. Factors associated with adherence to highly active antiretroviral therapy among children in two referral hospitals, northwest Ethiopia. Ethiop Med J. 2012;50(2):115-24.
Azmeraw, D., & Wasie, B. (2012). Factors associated with adherence to highly active antiretroviral therapy among children in two referral hospitals, northwest Ethiopia. Ethiopian Medical Journal, 50(2), 115-24.
Azmeraw D, Wasie B. Factors Associated With Adherence to Highly Active Antiretroviral Therapy Among Children in Two Referral Hospitals, Northwest Ethiopia. Ethiop Med J. 2012;50(2):115-24. PubMed PMID: 22924280.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors associated with adherence to highly active antiretroviral therapy among children in two referral hospitals, northwest Ethiopia. AU - Azmeraw,Daniel, AU - Wasie,Belaynew, PY - 2012/8/29/entrez PY - 2012/8/29/pubmed PY - 2012/9/5/medline SP - 115 EP - 24 JF - Ethiopian medical journal JO - Ethiop Med J VL - 50 IS - 2 N2 - BACKGROUND: highly active antiretroviral therapy (HAART) results in improved survival, clinical, immunological and virological response for children. Adherence to HAART is one of the very important factors which determine treatment success and occurrence of viral resistance. The need for near perfect adherence to lifelong antiretroviral therapy (ART) during childhood is a major challenge in the administration of HAART to HIV infected children. OBJECTIVE: the study was aimed to determine the level of adherence and factors associated with adherence to HAART among children in Felege Hiwot and Gondar University referral hospitals. METHODS: institution based cross-sectional study was conducted on 204 children in the paediatric ART clinics of Gondar University and Felege Hiwot hospitals. Sample size was determined by single population proportion formula and all children on ART for > or = 1 month and coming to the clinic during the data collection period were studied Ethical clearance was obtained from the Institutional Review Board of the University of Gondar. Data were collected by four nurses from the caregivers and patient charts using a pretested and structured questionnaire after informed consent. Descriptive statistics were calculated to describe study population and medical characteristics of participants while binary and multiple logistic regression analyses were used to determine the effect of factors on the outcome variable. RESULTS: The study included 204 children (123 from Flege Hiwot and 81 from Gondar). One hundred and seven (52.4%) were males and 97(47.6%) were females. Majority (82.4%) of caregivers were females. Thirty days optimum (> or = 95%) adherence rate was 80.9% for children. Adherence counseling before initiation (OR=4.37, 95%CI 1.17 - 16.37), caregiver formal education, (OR=4.85, 95%CI 1.89 - 12.39) and caregiver's ability to identify ARV drug correctly (OR = 8.61, 95%CI 2.59-28.68) were positively associated while care giver substance use (OR=0.31, 95%CI 0.10 - 0.93) was negatively associated with adherence as compared to their counter parts. CONCLUSION: optimum adherence rate to HAART in the study population was lower than the recommended Adherence counseling, caregiver education, substance use by caregiver, identification of ARVs determined adherence to HAART of children. Adherence assessment and counseling efforts should be continually integrated with ART for children and their caregivers. SN - 0014-1755 UR - https://www.unboundmedicine.com/medline/citation/22924280/Factors_associated_with_adherence_to_highly_active_antiretroviral_therapy_among_children_in_two_referral_hospitals_northwest_Ethiopia_ L2 - http://hivinsite.ucsf.edu/InSite?page=kb-03-02-09 DB - PRIME DP - Unbound Medicine ER -