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Korean red ginseng (Panax ginseng) ameliorates type 1 diabetes and restores immune cell compartments.
J Ethnopharmacol 2012; 144(2):225-33JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Historical records reveal that in traditional medicine, a disease similar to diabetes was treated with ginseng. Korean red ginseng has been considered beneficial as a dietary supplement for its anti-diabetic potential.

AIM

This study was designed to investigate the prophylactic potential of Korean red ginseng (KRG) extract (Panax ginseng C.A. Meyer Radix Rubra) in a well-established mouse model of Type 1 diabetes (T1D).

MATERIALS AND METHODS

The prophylactic effect of KRG extract was evaluated in mice fed with KRG extract for two weeks prior to induction of diabetes by streptozotocin (STZ) administration. Glucose levels and glucose challenge test results of KRG-treated diabetic mice were compared to those of untreated diabetic mice and healthy control mice. Examination of the immune compartments in lymphoid organs and immunohistochemical staining of pancreas for islet cell morphology and insulin producing beta cells were performed.

RESULTS

KRG extract significantly lowered blood glucose levels to an average of 250mg/dl from 350mg/dl and improved glucose challenge testing when applied as prophylaxis. Histological findings indicated that KRG extract protected against STZ-induced destruction of pancreatic tissue and restored insulin secretion. Strikingly, this effect was accompanied by restoration of lymphocytes in secondary lymphoid organs, suggesting that KRG extract facilitated immune homeostasis.

CONCLUSION

This is the first report to demonstrate the prophylactic function of KRG extract in ameliorating the hyperglycemia of T1D. Immune compartments of diabetic mice were found to be preserved in KRG-treated mice suggesting that Korean red ginseng may benefit T1D patients, not only for its hypoglycemic but also for its immunomodulatory effects.

Authors+Show Affiliations

Global Research Lab, Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, South Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22925946

Citation

Hong, Young Joo, et al. "Korean Red Ginseng (Panax Ginseng) Ameliorates Type 1 Diabetes and Restores Immune Cell Compartments." Journal of Ethnopharmacology, vol. 144, no. 2, 2012, pp. 225-33.
Hong YJ, Kim N, Lee K, et al. Korean red ginseng (Panax ginseng) ameliorates type 1 diabetes and restores immune cell compartments. J Ethnopharmacol. 2012;144(2):225-33.
Hong, Y. J., Kim, N., Lee, K., Hee Sonn, C., Eun Lee, J., Tae Kim, S., ... Lee, K. M. (2012). Korean red ginseng (Panax ginseng) ameliorates type 1 diabetes and restores immune cell compartments. Journal of Ethnopharmacology, 144(2), pp. 225-33. doi:10.1016/j.jep.2012.08.009.
Hong YJ, et al. Korean Red Ginseng (Panax Ginseng) Ameliorates Type 1 Diabetes and Restores Immune Cell Compartments. J Ethnopharmacol. 2012 Nov 21;144(2):225-33. PubMed PMID: 22925946.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Korean red ginseng (Panax ginseng) ameliorates type 1 diabetes and restores immune cell compartments. AU - Hong,Young Joo, AU - Kim,Nayoung, AU - Lee,Karim, AU - Hee Sonn,Chung, AU - Eun Lee,Jung, AU - Tae Kim,Sung, AU - Ho Baeg,In, AU - Lee,Kyung-Mi, Y1 - 2012/08/19/ PY - 2012/02/26/received PY - 2012/07/19/revised PY - 2012/08/07/accepted PY - 2012/8/29/entrez PY - 2012/8/29/pubmed PY - 2013/3/30/medline SP - 225 EP - 33 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 144 IS - 2 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Historical records reveal that in traditional medicine, a disease similar to diabetes was treated with ginseng. Korean red ginseng has been considered beneficial as a dietary supplement for its anti-diabetic potential. AIM: This study was designed to investigate the prophylactic potential of Korean red ginseng (KRG) extract (Panax ginseng C.A. Meyer Radix Rubra) in a well-established mouse model of Type 1 diabetes (T1D). MATERIALS AND METHODS: The prophylactic effect of KRG extract was evaluated in mice fed with KRG extract for two weeks prior to induction of diabetes by streptozotocin (STZ) administration. Glucose levels and glucose challenge test results of KRG-treated diabetic mice were compared to those of untreated diabetic mice and healthy control mice. Examination of the immune compartments in lymphoid organs and immunohistochemical staining of pancreas for islet cell morphology and insulin producing beta cells were performed. RESULTS: KRG extract significantly lowered blood glucose levels to an average of 250mg/dl from 350mg/dl and improved glucose challenge testing when applied as prophylaxis. Histological findings indicated that KRG extract protected against STZ-induced destruction of pancreatic tissue and restored insulin secretion. Strikingly, this effect was accompanied by restoration of lymphocytes in secondary lymphoid organs, suggesting that KRG extract facilitated immune homeostasis. CONCLUSION: This is the first report to demonstrate the prophylactic function of KRG extract in ameliorating the hyperglycemia of T1D. Immune compartments of diabetic mice were found to be preserved in KRG-treated mice suggesting that Korean red ginseng may benefit T1D patients, not only for its hypoglycemic but also for its immunomodulatory effects. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/22925946/Korean_red_ginseng__Panax_ginseng__ameliorates_type_1_diabetes_and_restores_immune_cell_compartments_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(12)00534-X DB - PRIME DP - Unbound Medicine ER -