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Caffeine and risk of Parkinson's disease in a large cohort of men and women.
Mov Disord. 2012 Sep 01; 27(10):1276-82.MD

Abstract

Caffeine consumption has been associated with a reduced risk of Parkinson's disease (PD). The association is strong and consistent in men, but uncertain in women, possibly because of an interaction with hormone replacement therapy (HRT). We sought to confirm these findings using data on PD incidence in the Cancer Prevention Study II Nutrition Cohort (CPS II-Nutrition), a large, prospective study of men and women. We conducted a prospective study of caffeine intake and risk of PD within the CPS II Nutrition Cohort. Intakes of coffee and other sources of caffeine were assessed at baseline. Incident cases of PD (n = 317; 197 men and 120 women) were confirmed by treating physicians and medical record review. Relative risks (RRs) were estimated using proportional hazards models, adjusting for age, smoking, and alcohol consumption. After adjustment for age, smoking, and alcohol intake, high caffeine consumption was associated with a reduced risk of PD. The RR comparing the 5th to the 1st quintile of caffeine intake was 0.43 (95% confidence interval [CI]: 0.26, 0.71; P trend = <0.002) in men, and 0.61 (95% CI: 0.34, 1.09; P trend = 0.05) in women. Among women, this association was stronger among never users of HRT (RR = 0.32) than among ever users (RR = 0.81; P interaction = 0.15). Consumption of decaffeinated coffee was not associated with PD risk. Findings from this large, prospective study of men and women are consistent with a protective effect of caffeine intake on PD incidence, with an attenuating influence of HRT in women. © 2012 Movement Disorder Society.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. palacios@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22927157

Citation

Palacios, Natalia, et al. "Caffeine and Risk of Parkinson's Disease in a Large Cohort of Men and Women." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 27, no. 10, 2012, pp. 1276-82.
Palacios N, Gao X, McCullough ML, et al. Caffeine and risk of Parkinson's disease in a large cohort of men and women. Mov Disord. 2012;27(10):1276-82.
Palacios, N., Gao, X., McCullough, M. L., Schwarzschild, M. A., Shah, R., Gapstur, S., & Ascherio, A. (2012). Caffeine and risk of Parkinson's disease in a large cohort of men and women. Movement Disorders : Official Journal of the Movement Disorder Society, 27(10), 1276-82. https://doi.org/10.1002/mds.25076
Palacios N, et al. Caffeine and Risk of Parkinson's Disease in a Large Cohort of Men and Women. Mov Disord. 2012 Sep 1;27(10):1276-82. PubMed PMID: 22927157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caffeine and risk of Parkinson's disease in a large cohort of men and women. AU - Palacios,Natalia, AU - Gao,Xiang, AU - McCullough,Marjorie L, AU - Schwarzschild,Michael A, AU - Shah,Roma, AU - Gapstur,Susan, AU - Ascherio,Alberto, Y1 - 2012/08/27/ PY - 2011/11/07/received PY - 2012/04/11/revised PY - 2012/05/09/accepted PY - 2012/8/29/entrez PY - 2012/8/29/pubmed PY - 2013/2/15/medline SP - 1276 EP - 82 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 27 IS - 10 N2 - Caffeine consumption has been associated with a reduced risk of Parkinson's disease (PD). The association is strong and consistent in men, but uncertain in women, possibly because of an interaction with hormone replacement therapy (HRT). We sought to confirm these findings using data on PD incidence in the Cancer Prevention Study II Nutrition Cohort (CPS II-Nutrition), a large, prospective study of men and women. We conducted a prospective study of caffeine intake and risk of PD within the CPS II Nutrition Cohort. Intakes of coffee and other sources of caffeine were assessed at baseline. Incident cases of PD (n = 317; 197 men and 120 women) were confirmed by treating physicians and medical record review. Relative risks (RRs) were estimated using proportional hazards models, adjusting for age, smoking, and alcohol consumption. After adjustment for age, smoking, and alcohol intake, high caffeine consumption was associated with a reduced risk of PD. The RR comparing the 5th to the 1st quintile of caffeine intake was 0.43 (95% confidence interval [CI]: 0.26, 0.71; P trend = <0.002) in men, and 0.61 (95% CI: 0.34, 1.09; P trend = 0.05) in women. Among women, this association was stronger among never users of HRT (RR = 0.32) than among ever users (RR = 0.81; P interaction = 0.15). Consumption of decaffeinated coffee was not associated with PD risk. Findings from this large, prospective study of men and women are consistent with a protective effect of caffeine intake on PD incidence, with an attenuating influence of HRT in women. © 2012 Movement Disorder Society. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/22927157/Caffeine_and_risk_of_Parkinson's_disease_in_a_large_cohort_of_men_and_women_ L2 - https://doi.org/10.1002/mds.25076 DB - PRIME DP - Unbound Medicine ER -