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Foetal exposure to maternal passive smoking is associated with childhood asthma, allergic rhinitis, and eczema.
ScientificWorldJournal 2012; 2012:542983S

Abstract

OBJECTIVE

We examined the hypothesis that foetal exposure to maternal passive smoking is associated with childhood asthma, allergic rhinitis, and eczema. METHODS. The study was a population-based cross-sectional survey of Hong Kong Chinese children aged ≤14 years carried out in 2005 to 2006. RESULTS. Foetal exposure to maternal passive smoking was significantly associated with wheeze ever (OR 2.05; 95% CI 1.58-2.67), current wheeze (OR 2.06; 95% CI 1.48-2.86), allergic rhinitis ever (OR 1.22; 95% CI 1.09-1.37), and eczema ever (OR 1.61; 95% CI 1.38-1.87). Foetal exposure to maternal active smoking was significantly associated with asthma ever (OR 2.10; 95% CI 1.14-3.84), wheeze ever (OR 2.46; 95% CI 1.27-4.78), and current wheeze (OR 2.74; 95% CI 1.24-6.01) but not with allergic rhinitis ever (OR 1.01; 95% CI 0.70-1.46) or eczema ever (OR 1.38; 95% CI 0.87-2.18). The dose response relationship between wheeze ever and current wheeze with increasing exposure, from no exposure to maternal passive smoking and then to maternal active smoking, further supports causality. CONCLUSION. There is significant association between foetal exposure to maternal passive smoking and maternal active smoking with childhood asthma and related atopic illnesses. Further studies are warranted to explore the potential causal relationship.

Authors+Show Affiliations

Department of Paediatrics & Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22927783

Citation

Lee, S L., et al. "Foetal Exposure to Maternal Passive Smoking Is Associated With Childhood Asthma, Allergic Rhinitis, and Eczema." TheScientificWorldJournal, vol. 2012, 2012, p. 542983.
Lee SL, Lam TH, Leung TH, et al. Foetal exposure to maternal passive smoking is associated with childhood asthma, allergic rhinitis, and eczema. ScientificWorldJournal. 2012;2012:542983.
Lee, S. L., Lam, T. H., Leung, T. H., Wong, W. H., Schooling, M., Leung, G. M., & Lau, Y. L. (2012). Foetal exposure to maternal passive smoking is associated with childhood asthma, allergic rhinitis, and eczema. TheScientificWorldJournal, 2012, p. 542983. doi:10.1100/2012/542983.
Lee SL, et al. Foetal Exposure to Maternal Passive Smoking Is Associated With Childhood Asthma, Allergic Rhinitis, and Eczema. ScientificWorldJournal. 2012;2012:542983. PubMed PMID: 22927783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Foetal exposure to maternal passive smoking is associated with childhood asthma, allergic rhinitis, and eczema. AU - Lee,S L, AU - Lam,T H, AU - Leung,T H, AU - Wong,W H S, AU - Schooling,M, AU - Leung,G M, AU - Lau,Y L, Y1 - 2012/08/13/ PY - 2012/03/13/received PY - 2012/04/14/accepted PY - 2012/8/29/entrez PY - 2012/8/29/pubmed PY - 2013/3/8/medline SP - 542983 EP - 542983 JF - TheScientificWorldJournal JO - ScientificWorldJournal VL - 2012 N2 - OBJECTIVE: We examined the hypothesis that foetal exposure to maternal passive smoking is associated with childhood asthma, allergic rhinitis, and eczema. METHODS. The study was a population-based cross-sectional survey of Hong Kong Chinese children aged ≤14 years carried out in 2005 to 2006. RESULTS. Foetal exposure to maternal passive smoking was significantly associated with wheeze ever (OR 2.05; 95% CI 1.58-2.67), current wheeze (OR 2.06; 95% CI 1.48-2.86), allergic rhinitis ever (OR 1.22; 95% CI 1.09-1.37), and eczema ever (OR 1.61; 95% CI 1.38-1.87). Foetal exposure to maternal active smoking was significantly associated with asthma ever (OR 2.10; 95% CI 1.14-3.84), wheeze ever (OR 2.46; 95% CI 1.27-4.78), and current wheeze (OR 2.74; 95% CI 1.24-6.01) but not with allergic rhinitis ever (OR 1.01; 95% CI 0.70-1.46) or eczema ever (OR 1.38; 95% CI 0.87-2.18). The dose response relationship between wheeze ever and current wheeze with increasing exposure, from no exposure to maternal passive smoking and then to maternal active smoking, further supports causality. CONCLUSION. There is significant association between foetal exposure to maternal passive smoking and maternal active smoking with childhood asthma and related atopic illnesses. Further studies are warranted to explore the potential causal relationship. SN - 1537-744X UR - https://www.unboundmedicine.com/medline/citation/22927783/Foetal_exposure_to_maternal_passive_smoking_is_associated_with_childhood_asthma_allergic_rhinitis_and_eczema_ L2 - https://dx.doi.org/10.1100/2012/542983 DB - PRIME DP - Unbound Medicine ER -