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Vitamin D and Parkinson's disease.
J Neurosci Res. 2012 Dec; 90(12):2227-36.JN

Abstract

Parkinson's disease (PD) is the second most common form of neurodegeneration among the elderly population. PD is clinically characterized by tremors, rigidity, slowness of movement, and postural imbalance. Interestingly, a significant association has been demonstrated between PD and low levels of vitamin D in the serum, and vitamin D supplement appears to have a beneficial clinical effect on PD. Genetic studies have provided the opportunity to determine which proteins link vitamin D to PD pathology, e.g., Nurr1 gene, toll-like receptor, gene related to lipid disorders, vascular endothelial factor, tyrosine hydroxylase, and angiogenin. Vitamin D also exerts its effects on cancer through nongenomic factors, e.g., bacillus Calmette-Guerin vaccination, interleukin-10, Wntβ-catenin signaling pathways, mitogen-activated protein kinase pathways, and the reduced form of the nicotinamide adenine dinucleotide phosphate. In conclusion, vitamin D might have a beneficial role in PD. Calcitriol is best used for PD because it is the active form of the vitamin D(3) metabolite and modulates inflammatory cytokine expression. Further investigation with calcitriol in PD is needed.

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Authors+Show Affiliations

Vinh Quôc Luong K
Vietnamese American Medical Research Foundation, Westminster, California, USA. lng2687765@aol.com
Thi Hoàng Nguyên L
No affiliation info available

MeSH

AnimalsBCG VaccineCalcitriolCholesterolGenetic Association StudiesHumansHypercalcemiaMiceMice, KnockoutNADPH OxidasesNuclear Receptor Subfamily 4, Group A, Member 2Parkinson DiseaseParkinsonian DisordersRatsReceptors, CalcitriolRibonuclease, PancreaticSignal TransductionToll-Like ReceptorsTyrosine 3-MonooxygenaseVascular Endothelial Growth Factor AVitamin DVitamin D Deficiency

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22930493

Citation

Vinh Quôc Luong, Khanh, and Lan Thi Hoàng Nguyên. "Vitamin D and Parkinson's Disease." Journal of Neuroscience Research, vol. 90, no. 12, 2012, pp. 2227-36.
Vinh Quôc Luong K, Thi Hoàng Nguyên L. Vitamin D and Parkinson's disease. J Neurosci Res. 2012;90(12):2227-36.
Vinh Quôc Luong, K., & Thi Hoàng Nguyên, L. (2012). Vitamin D and Parkinson's disease. Journal of Neuroscience Research, 90(12), 2227-36. https://doi.org/10.1002/jnr.23115
Vinh Quôc Luong K, Thi Hoàng Nguyên L. Vitamin D and Parkinson's Disease. J Neurosci Res. 2012;90(12):2227-36. PubMed PMID: 22930493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D and Parkinson's disease. AU - Vinh Quôc Luong,Khanh, AU - Thi Hoàng Nguyên,Lan, Y1 - 2012/08/28/ PY - 2012/05/26/received PY - 2012/06/21/accepted PY - 2012/8/30/entrez PY - 2012/8/30/pubmed PY - 2013/4/12/medline SP - 2227 EP - 36 JF - Journal of neuroscience research JO - J Neurosci Res VL - 90 IS - 12 N2 - Parkinson's disease (PD) is the second most common form of neurodegeneration among the elderly population. PD is clinically characterized by tremors, rigidity, slowness of movement, and postural imbalance. Interestingly, a significant association has been demonstrated between PD and low levels of vitamin D in the serum, and vitamin D supplement appears to have a beneficial clinical effect on PD. Genetic studies have provided the opportunity to determine which proteins link vitamin D to PD pathology, e.g., Nurr1 gene, toll-like receptor, gene related to lipid disorders, vascular endothelial factor, tyrosine hydroxylase, and angiogenin. Vitamin D also exerts its effects on cancer through nongenomic factors, e.g., bacillus Calmette-Guerin vaccination, interleukin-10, Wntβ-catenin signaling pathways, mitogen-activated protein kinase pathways, and the reduced form of the nicotinamide adenine dinucleotide phosphate. In conclusion, vitamin D might have a beneficial role in PD. Calcitriol is best used for PD because it is the active form of the vitamin D(3) metabolite and modulates inflammatory cytokine expression. Further investigation with calcitriol in PD is needed. SN - 1097-4547 UR - https://www.unboundmedicine.com/medline/citation/22930493/Vitamin_D_and_Parkinson's_disease_ L2 - https://doi.org/10.1002/jnr.23115 DB - PRIME DP - Unbound Medicine ER -