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Etiology and antimicrobial resistance of community-acquired pneumonia in adult patients in China.
Chin Med J (Engl). 2012 Sep; 125(17):2967-72.CM

Abstract

BACKGROUND

Appropriate antimicrobial therapy of community-acquired pneumonia (CAP) is mainly based on the distribution of etiology and antimicrobial resistance of major pathogens. We performed a prospective observational study of adult with CAP in 36 hospitals in China.

METHODS

Etiological pathogens were isolated in each of the centers, and all of the isolated pathogens were sent to Zhongshan Hospital for antimicrobial susceptibility tests using agar dilution.

RESULTS

A total of 593 patients were enrolled in this study, and 242 strains of bacteria were isolated from 225 patients. Streptococcus pneumoniae (79/242, 32.6%) was the most frequently isolated pathogen, followed by Haemophilus influenzae (55/242, 22.7%) and Klebsiella pneumoniae (25/242, 10.3%). Totally 527 patients underwent serological tests for atypical pathogens; Mycoplasma pneumoniae and Chlamydia pneumoniae infections were identified in 205 (38.9%) and 60 (11.4%) patients respectively. Legionella pneumophila infections were identified in 4.0% (13/324) of patients. The non-susceptibility rate of isolated Streptococcus pneumoniae to erythromycin and penicillin was 63.2% and 19.1% respectively. Six patients died from the disease, the 30-day mortality rate was 1.1% (6/533).

CONCLUSIONS

The top three bacteria responsible for CAP in Chinese adults were Streptococcus pneumonia, Haemophilus influenza and Klebsiella pneumonia. There was also a high prevalence of atypical pathogens and mixed pathogens. The resistance rates of the major isolated pathogens were relatively low except for the high prevalence of macrolide resistance in Streptococcus pneumoniae.

Authors+Show Affiliations

Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22932165

Citation

Tao, Li-Li, et al. "Etiology and Antimicrobial Resistance of Community-acquired Pneumonia in Adult Patients in China." Chinese Medical Journal, vol. 125, no. 17, 2012, pp. 2967-72.
Tao LL, Hu BJ, He LX, et al. Etiology and antimicrobial resistance of community-acquired pneumonia in adult patients in China. Chin Med J (Engl). 2012;125(17):2967-72.
Tao, L. L., Hu, B. J., He, L. X., Wei, L., Xie, H. M., Wang, B. Q., Li, H. Y., Chen, X. H., Zhou, C. M., & Deng, W. W. (2012). Etiology and antimicrobial resistance of community-acquired pneumonia in adult patients in China. Chinese Medical Journal, 125(17), 2967-72.
Tao LL, et al. Etiology and Antimicrobial Resistance of Community-acquired Pneumonia in Adult Patients in China. Chin Med J (Engl). 2012;125(17):2967-72. PubMed PMID: 22932165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Etiology and antimicrobial resistance of community-acquired pneumonia in adult patients in China. AU - Tao,Li-Li, AU - Hu,Bi-Jie, AU - He,Li-Xian, AU - Wei,Li, AU - Xie,Hong-Mei, AU - Wang,Bao-Qing, AU - Li,Hua-Ying, AU - Chen,Xue-Hua, AU - Zhou,Chun-Mei, AU - Deng,Wei-Wu, PY - 2012/8/31/entrez PY - 2012/8/31/pubmed PY - 2013/5/18/medline SP - 2967 EP - 72 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 125 IS - 17 N2 - BACKGROUND: Appropriate antimicrobial therapy of community-acquired pneumonia (CAP) is mainly based on the distribution of etiology and antimicrobial resistance of major pathogens. We performed a prospective observational study of adult with CAP in 36 hospitals in China. METHODS: Etiological pathogens were isolated in each of the centers, and all of the isolated pathogens were sent to Zhongshan Hospital for antimicrobial susceptibility tests using agar dilution. RESULTS: A total of 593 patients were enrolled in this study, and 242 strains of bacteria were isolated from 225 patients. Streptococcus pneumoniae (79/242, 32.6%) was the most frequently isolated pathogen, followed by Haemophilus influenzae (55/242, 22.7%) and Klebsiella pneumoniae (25/242, 10.3%). Totally 527 patients underwent serological tests for atypical pathogens; Mycoplasma pneumoniae and Chlamydia pneumoniae infections were identified in 205 (38.9%) and 60 (11.4%) patients respectively. Legionella pneumophila infections were identified in 4.0% (13/324) of patients. The non-susceptibility rate of isolated Streptococcus pneumoniae to erythromycin and penicillin was 63.2% and 19.1% respectively. Six patients died from the disease, the 30-day mortality rate was 1.1% (6/533). CONCLUSIONS: The top three bacteria responsible for CAP in Chinese adults were Streptococcus pneumonia, Haemophilus influenza and Klebsiella pneumonia. There was also a high prevalence of atypical pathogens and mixed pathogens. The resistance rates of the major isolated pathogens were relatively low except for the high prevalence of macrolide resistance in Streptococcus pneumoniae. SN - 2542-5641 UR - https://www.unboundmedicine.com/medline/citation/22932165/Etiology_and_antimicrobial_resistance_of_community_acquired_pneumonia_in_adult_patients_in_China_ L2 - https://journals.lww.com/22932165.pmid DB - PRIME DP - Unbound Medicine ER -