TY - JOUR T1 - Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault's rousettes to pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders. AU - Lau,Susanna K P, AU - Li,Kenneth S M, AU - Tsang,Alan K L, AU - Shek,Chung-Tong, AU - Wang,Ming, AU - Choi,Garnet K Y, AU - Guo,Rongtong, AU - Wong,Beatrice H L, AU - Poon,Rosana W S, AU - Lam,Carol S F, AU - Wang,Sylvia Y H, AU - Fan,Rachel Y Y, AU - Chan,Kwok-Hung, AU - Zheng,Bo-Jian, AU - Woo,Patrick C Y, AU - Yuen,Kwok-Yung, Y1 - 2012/08/29/ PY - 2012/8/31/entrez PY - 2012/8/31/pubmed PY - 2013/1/8/medline SP - 11906 EP - 18 JF - Journal of virology JO - J Virol VL - 86 IS - 21 N2 - Although coronaviruses are known to infect various animals by adapting to new hosts, interspecies transmission events are still poorly understood. During a surveillance study from 2005 to 2010, a novel alphacoronavirus, BatCoV HKU10, was detected in two very different bat species, Ro-BatCoV HKU10 in Leschenault's rousettes (Rousettus leschenaulti) (fruit bats in the suborder Megachiroptera) in Guangdong and Hi-BatCoV HKU10 in Pomona leaf-nosed bats (Hipposideros pomona) (insectivorous bats in the suborder Microchiroptera) in Hong Kong. Although infected bats appeared to be healthy, Pomona leaf-nosed bats carrying Hi-BatCoV HKU10 had lower body weights than uninfected bats. To investigate possible interspecies transmission between the two bat species, the complete genomes of two Ro-BatCoV HKU10 and six Hi-BatCoV HKU10 strains were sequenced. Genome and phylogenetic analyses showed that Ro-BatCoV HKU10 and Hi-BatCoV HKU10 represented a novel alphacoronavirus species, sharing highly similar genomes except in the genes encoding spike proteins, which had only 60.5% amino acid identities. Evolution of the spike protein was also rapid in Hi-BatCoV HKU10 strains from 2005 to 2006 but stabilized thereafter. Molecular-clock analysis dated the most recent common ancestor of all BatCoV HKU10 strains to 1959 (highest posterior density regions at 95% [HPDs], 1886 to 2002) and that of Hi-BatCoV HKU10 to 1986 (HPDs, 1956 to 2004). The data suggested recent interspecies transmission from Leschenault's rousettes to Pomona leaf-nosed bats in southern China. Notably, the rapid adaptive genetic change in BatCoV HKU10 spike protein by ~40% amino acid divergence after recent interspecies transmission was even greater than the ~20% amino acid divergence between spike proteins of severe acute respiratory syndrome-related Rhinolophus bat coronavirus (SARSr-CoV) in bats and civets. This study provided the first evidence for interspecies transmission of coronavirus between bats of different suborders. SN - 1098-5514 UR - https://www.unboundmedicine.com/medline/citation/22933277/Recent_transmission_of_a_novel_alphacoronavirus_bat_coronavirus_HKU10_from_Leschenault's_rousettes_to_pomona_leaf_nosed_bats:_first_evidence_of_interspecies_transmission_of_coronavirus_between_bats_of_different_suborders_ L2 - https://journals.asm.org/doi/10.1128/JVI.01305-12?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -