Tags

Type your tag names separated by a space and hit enter

Etiology of community-acquired pneumonia in hospitalized children in northern Taiwan.
Pediatr Infect Dis J. 2012 Nov; 31(11):e196-201.PI

Abstract

BACKGROUND

Pneumonia is the leading reason for hospitalization in children. The heptavalent pneumococcal conjugate vaccine was introduced in Taiwan in October 2005. There has been no comprehensive study of the etiology of childhood community-acquired pneumonia (CAP), either in the pre- or postpneumococcal conjugate vaccine era, in Taiwan.

METHODS

From August 2001 to July 2002, consecutive children admitted to a teaching hospital with radiologically confirmed CAP were prospectively enrolled. The following were considered indicative of infection when positive: blood or pleural effusion bacterial culture or urinary Streptococcus pneumoniae antigen test (Binax NOW), direct immunofluorescent antigen test for Chlamydia species and viruses, virus isolation and identification and viral, mycoplasmal or chlamydial serologic tests.

RESULTS

A total of 209 children were included, and 102 children (48.8%) were male. Patients' ages ranged from 7 months to 16 years with a median of 4 years and 3 months. The combined tests identified at least 1 etiologic agent in 85.6% of all cases, including typical bacterial pathogens in 88 cases (42.1%; 86 S. pneumoniae, 1 methicillin-resistant Staphylococcus aureus and 1 Mycobacterium tuberculosis), Mycoplasma pneumoniae in 77 cases (36.8%), Chlamydia species in 24 cases (11.5%), viral etiology in 86 cases (41.1%) and mixed viral-bacterial infections in 69 cases (33%). Children with S. pneumoniae infection were significantly younger than those with Mycoplasma pneumoniae infection (P = 0.0055) or unknown etiology (P = 0.0140).

CONCLUSION

S. pneumoniae, Mycoplasma pneumoniae and viruses were equally common etiologic agents of childhood CAP in Taiwan. Frequent coinfection increased the difficulty of both predicting the responsible organisms and choosing empiric antibiotics for the management of pediatric CAP.

Authors+Show Affiliations

Division of Pediatric Infectious Diseases, Chang Gung Memorial Hospital, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22935863

Citation

Chen, Chih-Jung, et al. "Etiology of Community-acquired Pneumonia in Hospitalized Children in Northern Taiwan." The Pediatric Infectious Disease Journal, vol. 31, no. 11, 2012, pp. e196-201.
Chen CJ, Lin PY, Tsai MH, et al. Etiology of community-acquired pneumonia in hospitalized children in northern Taiwan. Pediatr Infect Dis J. 2012;31(11):e196-201.
Chen, C. J., Lin, P. Y., Tsai, M. H., Huang, C. G., Tsao, K. C., Wong, K. S., Chang, L. Y., Chiu, C. H., Lin, T. Y., & Huang, Y. C. (2012). Etiology of community-acquired pneumonia in hospitalized children in northern Taiwan. The Pediatric Infectious Disease Journal, 31(11), e196-201. https://doi.org/10.1097/INF.0b013e31826eb5a7
Chen CJ, et al. Etiology of Community-acquired Pneumonia in Hospitalized Children in Northern Taiwan. Pediatr Infect Dis J. 2012;31(11):e196-201. PubMed PMID: 22935863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Etiology of community-acquired pneumonia in hospitalized children in northern Taiwan. AU - Chen,Chih-Jung, AU - Lin,Pen-Yi, AU - Tsai,Ming-Han, AU - Huang,Chung-Guei, AU - Tsao,Kuo-Chien, AU - Wong,Kin-Sun, AU - Chang,Luan-Yin, AU - Chiu,Cheng-Hsun, AU - Lin,Tzou-Yien, AU - Huang,Yhu-Chering, PY - 2012/9/1/entrez PY - 2012/9/1/pubmed PY - 2013/3/13/medline SP - e196 EP - 201 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 31 IS - 11 N2 - BACKGROUND: Pneumonia is the leading reason for hospitalization in children. The heptavalent pneumococcal conjugate vaccine was introduced in Taiwan in October 2005. There has been no comprehensive study of the etiology of childhood community-acquired pneumonia (CAP), either in the pre- or postpneumococcal conjugate vaccine era, in Taiwan. METHODS: From August 2001 to July 2002, consecutive children admitted to a teaching hospital with radiologically confirmed CAP were prospectively enrolled. The following were considered indicative of infection when positive: blood or pleural effusion bacterial culture or urinary Streptococcus pneumoniae antigen test (Binax NOW), direct immunofluorescent antigen test for Chlamydia species and viruses, virus isolation and identification and viral, mycoplasmal or chlamydial serologic tests. RESULTS: A total of 209 children were included, and 102 children (48.8%) were male. Patients' ages ranged from 7 months to 16 years with a median of 4 years and 3 months. The combined tests identified at least 1 etiologic agent in 85.6% of all cases, including typical bacterial pathogens in 88 cases (42.1%; 86 S. pneumoniae, 1 methicillin-resistant Staphylococcus aureus and 1 Mycobacterium tuberculosis), Mycoplasma pneumoniae in 77 cases (36.8%), Chlamydia species in 24 cases (11.5%), viral etiology in 86 cases (41.1%) and mixed viral-bacterial infections in 69 cases (33%). Children with S. pneumoniae infection were significantly younger than those with Mycoplasma pneumoniae infection (P = 0.0055) or unknown etiology (P = 0.0140). CONCLUSION: S. pneumoniae, Mycoplasma pneumoniae and viruses were equally common etiologic agents of childhood CAP in Taiwan. Frequent coinfection increased the difficulty of both predicting the responsible organisms and choosing empiric antibiotics for the management of pediatric CAP. SN - 1532-0987 UR - https://www.unboundmedicine.com/medline/citation/22935863/Etiology_of_community_acquired_pneumonia_in_hospitalized_children_in_northern_Taiwan_ L2 - https://doi.org/10.1097/INF.0b013e31826eb5a7 DB - PRIME DP - Unbound Medicine ER -