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Acute social stress increases biochemical and self report markers of stress without altering spatial learning in humans.
Neuro Endocrinol Lett. 2012; 33(4):425-30.NE

Abstract

OBJECTIVES

Spatial learning is shown to be influenced by acute stress in both human and other animals. However, the intricacies of this relationship are unclear. Based on prior findings we hypothesized that compared to a control condition, a social stress condition would not affect spatial learning performance despite elevated biochemical markers of stress.

METHODS

The present study tested the effects of social stress in human males and females on a subsequent spatial learning task. Social stress induction consisted of evaluative stress (the Trier Social Stress Test, TSST) compared to a placebo social stress.

RESULTS

Compared to the placebo condition, the TSST resulted in significantly elevated cortisol and alpha amylase levels at multiple time points following stress induction. In accord, cognitive appraisal measures also showed that participants in the TSST group experienced greater perceived stress compared to the placebo group. However, there were no group differences in performance on a spatial learning task.

CONCLUSION

Our findings suggest that unlike physiological stress, social stress does not result in alterations in spatial learning in humans. It is possible that moderate social evaluative stress in humans works to prevent acute stress-mediated alterations in hippocampal learning processes..

Authors+Show Affiliations

Nova Southeastern University, Fort Lauderdale, FL, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22936252

Citation

Klopp, Christine, et al. "Acute Social Stress Increases Biochemical and Self Report Markers of Stress Without Altering Spatial Learning in Humans." Neuro Endocrinology Letters, vol. 33, no. 4, 2012, pp. 425-30.
Klopp C, Garcia C, Schulman AH, et al. Acute social stress increases biochemical and self report markers of stress without altering spatial learning in humans. Neuro Endocrinol Lett. 2012;33(4):425-30.
Klopp, C., Garcia, C., Schulman, A. H., Ward, C. P., & Tartar, J. L. (2012). Acute social stress increases biochemical and self report markers of stress without altering spatial learning in humans. Neuro Endocrinology Letters, 33(4), 425-30.
Klopp C, et al. Acute Social Stress Increases Biochemical and Self Report Markers of Stress Without Altering Spatial Learning in Humans. Neuro Endocrinol Lett. 2012;33(4):425-30. PubMed PMID: 22936252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute social stress increases biochemical and self report markers of stress without altering spatial learning in humans. AU - Klopp,Christine, AU - Garcia,Carlos, AU - Schulman,Allan H, AU - Ward,Christopher P, AU - Tartar,Jaime L, PY - 2012/07/22/received PY - 2012/07/22/accepted PY - 2012/9/1/entrez PY - 2012/9/1/pubmed PY - 2013/1/9/medline SP - 425 EP - 30 JF - Neuro endocrinology letters JO - Neuro Endocrinol Lett VL - 33 IS - 4 N2 - OBJECTIVES: Spatial learning is shown to be influenced by acute stress in both human and other animals. However, the intricacies of this relationship are unclear. Based on prior findings we hypothesized that compared to a control condition, a social stress condition would not affect spatial learning performance despite elevated biochemical markers of stress. METHODS: The present study tested the effects of social stress in human males and females on a subsequent spatial learning task. Social stress induction consisted of evaluative stress (the Trier Social Stress Test, TSST) compared to a placebo social stress. RESULTS: Compared to the placebo condition, the TSST resulted in significantly elevated cortisol and alpha amylase levels at multiple time points following stress induction. In accord, cognitive appraisal measures also showed that participants in the TSST group experienced greater perceived stress compared to the placebo group. However, there were no group differences in performance on a spatial learning task. CONCLUSION: Our findings suggest that unlike physiological stress, social stress does not result in alterations in spatial learning in humans. It is possible that moderate social evaluative stress in humans works to prevent acute stress-mediated alterations in hippocampal learning processes.. SN - 0172-780X UR - https://www.unboundmedicine.com/medline/citation/22936252/Acute_social_stress_increases_biochemical_and_self_report_markers_of_stress_without_altering_spatial_learning_in_humans_ L2 - https://medlineplus.gov/stress.html DB - PRIME DP - Unbound Medicine ER -