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Flavonoid oligoglycosides from Ophioglossum vulgatum L. having wound healing properties.
Planta Med. 2012 Oct; 78(15):1639-44.PM

Abstract

Two new glycosylated and acylated flavonols, viz. quercetin-3-O-[(6-caffeoyl)-β-glucopyranosyl (1 → 3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside (2), and kaempferol-3-O-[(6-caffeoyl)-β-glucopyranosyl (1 → 3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside (3), together with the known quercetin-3-O-methyl ether (1), were isolated from the aerial parts of the fern Ophioglossum vulgatum L. Their structures were established by means of 1D and 2D NMR spectra, as well as ESI-MS and ESI-HRMS spectra. Compounds 1-3 were all found to be active in scratch-wound healing assays on keratinocytes, with 3 being the most active one and showing maximum activity at 20 µM.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Clericuzio M
Dipartimento di Scienze ed Innovazione Tecnologica, Università del Piemonte Orientale, Alessandria, Italy. marco.clericuzio@mfn.unipmn.it
Tinello S
No affiliation info available
Burlando B
No affiliation info available
Ranzato E
No affiliation info available
Martinotti S
No affiliation info available
Cornara L
No affiliation info available
La Rocca A
No affiliation info available

MeSH

Blood PlateletsDose-Response Relationship, DrugFernsFlavonolsGlycosidesHumansInhibitory Concentration 50KaempferolsKeratinocytesMagnetic Resonance SpectroscopyMolecular StructurePlant Components, AerialPlant ExtractsPlants, MedicinalQuercetinSpectrometry, Mass, Electrospray IonizationWound Healing

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22936389

Citation

Clericuzio, Marco, et al. "Flavonoid Oligoglycosides From Ophioglossum Vulgatum L. Having Wound Healing Properties." Planta Medica, vol. 78, no. 15, 2012, pp. 1639-44.
Clericuzio M, Tinello S, Burlando B, et al. Flavonoid oligoglycosides from Ophioglossum vulgatum L. having wound healing properties. Planta Med. 2012;78(15):1639-44.
Clericuzio, M., Tinello, S., Burlando, B., Ranzato, E., Martinotti, S., Cornara, L., & La Rocca, A. (2012). Flavonoid oligoglycosides from Ophioglossum vulgatum L. having wound healing properties. Planta Medica, 78(15), 1639-44. https://doi.org/10.1055/s-0032-1315149
Clericuzio M, et al. Flavonoid Oligoglycosides From Ophioglossum Vulgatum L. Having Wound Healing Properties. Planta Med. 2012;78(15):1639-44. PubMed PMID: 22936389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flavonoid oligoglycosides from Ophioglossum vulgatum L. having wound healing properties. AU - Clericuzio,Marco, AU - Tinello,Stefano, AU - Burlando,Bruno, AU - Ranzato,Elia, AU - Martinotti,Simona, AU - Cornara,Laura, AU - La Rocca,Arianna, Y1 - 2012/08/30/ PY - 2012/9/1/entrez PY - 2012/9/1/pubmed PY - 2013/4/23/medline SP - 1639 EP - 44 JF - Planta medica JO - Planta Med VL - 78 IS - 15 N2 - Two new glycosylated and acylated flavonols, viz. quercetin-3-O-[(6-caffeoyl)-β-glucopyranosyl (1 → 3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside (2), and kaempferol-3-O-[(6-caffeoyl)-β-glucopyranosyl (1 → 3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside (3), together with the known quercetin-3-O-methyl ether (1), were isolated from the aerial parts of the fern Ophioglossum vulgatum L. Their structures were established by means of 1D and 2D NMR spectra, as well as ESI-MS and ESI-HRMS spectra. Compounds 1-3 were all found to be active in scratch-wound healing assays on keratinocytes, with 3 being the most active one and showing maximum activity at 20 µM. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/22936389/Flavonoid_oligoglycosides_from_Ophioglossum_vulgatum_L__having_wound_healing_properties_ DB - PRIME DP - Unbound Medicine ER -