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Cell-mediated non-allergic rhinitis in children.
Int J Pediatr Otorhinolaryngol. 2012 Dec; 76(12):1741-5.IJ

Abstract

OBJECTIVE

Non-allergic rhinitis is a heterogeneous disease whose etiology is largely unknown. Nasal cytology only allows us to recognize different non-allergic rhinitis forms on the basis of the prevalent inflammatory cell infiltrate: non-allergic rhinitis with eosinophils, with neutrophils, with mast-cells and with both eosinophils and mast-cells. The aim of this study is to define the incidence, clinical features and comorbidity of the different types of cell-mediated non-allergic rhinitis in a pediatric age group.

METHODS

One hundred and fourteen non-allergic children with chronic nasal obstruction and associated symptoms (rhinorrhea, sneezing and nasal itchiness) were retrospectively selected. All patients had been submitted to a clinical history, pediatric evaluation, anterior rhinoscopy and fiberendoscopy, rhinomanometry and nasal cytology.

RESULTS

Non-allergic rhinitis with neutrophils was present in 46 (40.4%) children, non-allergic rhinitis with eosinophils in 53 (46.5%), non-allergic rhinitis with mast-cells in 12 (10.5%) and non-allergic rhinitis with both eosinophils and mast-cells in 3 (2.6%). Nasal obstruction was prevalent in non-allergic rhinitis with eosinophils and in non-allergic rhinitis with mast-cells patients (P<0.001) whereas rhinorrea and sneezing only in the form with eosinophils (P<0.0001). Nasal itching on the other hand was prevalent in the form with mast-cells (P<0.0003). Non-allergic rhinitis with eosinophils group showed a higher probability of asthma (P<0.02) and respiratory sleep disorders (P<0.04).

CONCLUSIONS

In the pediatric age group the most frequent forms of non-allergic rhinitis are those with eosinophils or with neutrophils. A diagnosis of non-allergic rhinitis with eosinophils in children presumes more severe symptoms and a higher incidence of pulmonary disease and roncopathy.

Authors+Show Affiliations

Department of Otorhinolaryngology, University of Foggia, Foggia, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22939589

Citation

Maselli Del Giudice, Alessandro, et al. "Cell-mediated Non-allergic Rhinitis in Children." International Journal of Pediatric Otorhinolaryngology, vol. 76, no. 12, 2012, pp. 1741-5.
Maselli Del Giudice A, Barbara M, Russo GM, et al. Cell-mediated non-allergic rhinitis in children. Int J Pediatr Otorhinolaryngol. 2012;76(12):1741-5.
Maselli Del Giudice, A., Barbara, M., Russo, G. M., Fiocca Matthews, E., & Cassano, M. (2012). Cell-mediated non-allergic rhinitis in children. International Journal of Pediatric Otorhinolaryngology, 76(12), 1741-5. https://doi.org/10.1016/j.ijporl.2012.08.013
Maselli Del Giudice A, et al. Cell-mediated Non-allergic Rhinitis in Children. Int J Pediatr Otorhinolaryngol. 2012;76(12):1741-5. PubMed PMID: 22939589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cell-mediated non-allergic rhinitis in children. AU - Maselli Del Giudice,Alessandro, AU - Barbara,Michele, AU - Russo,Giuseppe Maria, AU - Fiocca Matthews,Emily, AU - Cassano,Michele, Y1 - 2012/08/30/ PY - 2011/11/14/received PY - 2012/08/08/revised PY - 2012/08/10/accepted PY - 2012/9/4/entrez PY - 2012/9/4/pubmed PY - 2013/5/8/medline SP - 1741 EP - 5 JF - International journal of pediatric otorhinolaryngology JO - Int J Pediatr Otorhinolaryngol VL - 76 IS - 12 N2 - OBJECTIVE: Non-allergic rhinitis is a heterogeneous disease whose etiology is largely unknown. Nasal cytology only allows us to recognize different non-allergic rhinitis forms on the basis of the prevalent inflammatory cell infiltrate: non-allergic rhinitis with eosinophils, with neutrophils, with mast-cells and with both eosinophils and mast-cells. The aim of this study is to define the incidence, clinical features and comorbidity of the different types of cell-mediated non-allergic rhinitis in a pediatric age group. METHODS: One hundred and fourteen non-allergic children with chronic nasal obstruction and associated symptoms (rhinorrhea, sneezing and nasal itchiness) were retrospectively selected. All patients had been submitted to a clinical history, pediatric evaluation, anterior rhinoscopy and fiberendoscopy, rhinomanometry and nasal cytology. RESULTS: Non-allergic rhinitis with neutrophils was present in 46 (40.4%) children, non-allergic rhinitis with eosinophils in 53 (46.5%), non-allergic rhinitis with mast-cells in 12 (10.5%) and non-allergic rhinitis with both eosinophils and mast-cells in 3 (2.6%). Nasal obstruction was prevalent in non-allergic rhinitis with eosinophils and in non-allergic rhinitis with mast-cells patients (P<0.001) whereas rhinorrea and sneezing only in the form with eosinophils (P<0.0001). Nasal itching on the other hand was prevalent in the form with mast-cells (P<0.0003). Non-allergic rhinitis with eosinophils group showed a higher probability of asthma (P<0.02) and respiratory sleep disorders (P<0.04). CONCLUSIONS: In the pediatric age group the most frequent forms of non-allergic rhinitis are those with eosinophils or with neutrophils. A diagnosis of non-allergic rhinitis with eosinophils in children presumes more severe symptoms and a higher incidence of pulmonary disease and roncopathy. SN - 1872-8464 UR - https://www.unboundmedicine.com/medline/citation/22939589/Cell_mediated_non_allergic_rhinitis_in_children_ DB - PRIME DP - Unbound Medicine ER -