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Migraine headache: a review of the molecular genetics of a common disorder.

Abstract

This tutorial summarises the state-of-the-art on migraine genetics and looks at the possible future direction of this field of research. The view of migraine as a genetic disorder, initially based on epidemiological observations of transmission of the condition within families, was subsequently confirmed by the identification of monogenic forms of "syndromic" migraine, such as familial hemiplegic migraine. We are currently witnessing a change in the way genetic analysis is used in migraine research: rather than studying modalities of inheritance in non-monogenic forms of migraine and in the persistent modalities of migraine headache, researchers are now tending to focus on the search for genetic markers of dysfunction in biological systems. One example of the evolution of migraine genetic research is provided by the recent efforts to shed light on the pharmacogenomic mechanisms of drug response in migraineurs. In addition, novel molecular approaches about to be introduced are expected to further increase knowledge on this topic and improve patient management.

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  • Authors+Show Affiliations

    ,

    Don Carlo Gnocchi Onlus Foundation, Rome, Italy.

    ,

    Source

    The journal of headache and pain 13:7 2012 Oct pg 571-80

    MeSH

    Genetic Predisposition to Disease
    Humans
    Migraine Disorders
    Molecular Biology
    Pharmacogenetics

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    22940869

    Citation

    Di Lorenzo, Cherubino, et al. "Migraine Headache: a Review of the Molecular Genetics of a Common Disorder." The Journal of Headache and Pain, vol. 13, no. 7, 2012, pp. 571-80.
    Di Lorenzo C, Grieco GS, Santorelli FM. Migraine headache: a review of the molecular genetics of a common disorder. J Headache Pain. 2012;13(7):571-80.
    Di Lorenzo, C., Grieco, G. S., & Santorelli, F. M. (2012). Migraine headache: a review of the molecular genetics of a common disorder. The Journal of Headache and Pain, 13(7), pp. 571-80. doi:10.1007/s10194-012-0478-x.
    Di Lorenzo C, Grieco GS, Santorelli FM. Migraine Headache: a Review of the Molecular Genetics of a Common Disorder. J Headache Pain. 2012;13(7):571-80. PubMed PMID: 22940869.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Migraine headache: a review of the molecular genetics of a common disorder. AU - Di Lorenzo,Cherubino, AU - Grieco,Gaetano S, AU - Santorelli,Filippo M, Y1 - 2012/09/01/ PY - 2012/06/22/received PY - 2012/08/18/accepted PY - 2012/9/4/entrez PY - 2012/9/4/pubmed PY - 2013/7/9/medline SP - 571 EP - 80 JF - The journal of headache and pain JO - J Headache Pain VL - 13 IS - 7 N2 - This tutorial summarises the state-of-the-art on migraine genetics and looks at the possible future direction of this field of research. The view of migraine as a genetic disorder, initially based on epidemiological observations of transmission of the condition within families, was subsequently confirmed by the identification of monogenic forms of "syndromic" migraine, such as familial hemiplegic migraine. We are currently witnessing a change in the way genetic analysis is used in migraine research: rather than studying modalities of inheritance in non-monogenic forms of migraine and in the persistent modalities of migraine headache, researchers are now tending to focus on the search for genetic markers of dysfunction in biological systems. One example of the evolution of migraine genetic research is provided by the recent efforts to shed light on the pharmacogenomic mechanisms of drug response in migraineurs. In addition, novel molecular approaches about to be introduced are expected to further increase knowledge on this topic and improve patient management. SN - 1129-2377 UR - https://www.unboundmedicine.com/medline/citation/22940869/full_citation L2 - https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1007/s10194-012-0478-x DB - PRIME DP - Unbound Medicine ER -