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BRAF V600E mutation independently predicts central compartment lymph node metastasis in patients with papillary thyroid cancer.
Ann Surg Oncol. 2013 Jan; 20(1):47-52.AS

Abstract

PURPOSE

This study was designed to examine whether available preoperative clinical parameters, including B-type Raf kinase (BRAF) V600E mutation status, can identify patients at risk for central compartment lymph node metastasis (CLNM).

METHODS

Under an institutional review board-approved protocol, we conducted a single-center, retrospective review of all patients who had initial thyroidectomy for histologic papillary thyroid carcinoma (PTC) during 2010. The presence of CLNM was examined for correlation with available preoperative clinical parameters, including tumor size, gender, age, and BRAF mutation status.

RESULTS

Cervical lymph node resection and molecular testing on FNAB or histopathologic specimen was performed on a consecutive series of 156 study patients with histologic PTC. Overall, CLNM was diagnosed in 37% and 46% were BRAF-mutation-positive. BRAF positivity was the only clinical parameter associated with CLNM (BRAF, p=0.002; tumor size≥2 cm, p=0.16; male gender, p=0.1; age≥45 years, p=0.3) and remained an independent predictor of CLNM on multiple logistic regression analysis (odds ratio (OR) 3.2, p=0.001). The PPV and NPV of BRAF positivity for CLNM was 50 and 74%, respectively. When restricting the analysis to the subset of 38 patients who had molecular testing performed preoperatively on FNAB, the PPV and NPV of BRAF positivity for CLNM was 47 and 91%, respectively, and BRAF positivity was still a significant predictor of CLNM on both univariate (OR 8.4, p=0.01) and multivariate (OR 9.7, p=0.02) analyses.

CONCLUSIONS

Of the commonly used clinical parameters available preoperatively, the BRAF V600E mutation is the only independent predictor of CLNM in PTC and can be utilized to guide the extent of initial surgery.

Authors+Show Affiliations

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22941165

Citation

Howell, Gina M., et al. "BRAF V600E Mutation Independently Predicts Central Compartment Lymph Node Metastasis in Patients With Papillary Thyroid Cancer." Annals of Surgical Oncology, vol. 20, no. 1, 2013, pp. 47-52.
Howell GM, Nikiforova MN, Carty SE, et al. BRAF V600E mutation independently predicts central compartment lymph node metastasis in patients with papillary thyroid cancer. Ann Surg Oncol. 2013;20(1):47-52.
Howell, G. M., Nikiforova, M. N., Carty, S. E., Armstrong, M. J., Hodak, S. P., Stang, M. T., McCoy, K. L., Nikiforov, Y. E., & Yip, L. (2013). BRAF V600E mutation independently predicts central compartment lymph node metastasis in patients with papillary thyroid cancer. Annals of Surgical Oncology, 20(1), 47-52. https://doi.org/10.1245/s10434-012-2611-0
Howell GM, et al. BRAF V600E Mutation Independently Predicts Central Compartment Lymph Node Metastasis in Patients With Papillary Thyroid Cancer. Ann Surg Oncol. 2013;20(1):47-52. PubMed PMID: 22941165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - BRAF V600E mutation independently predicts central compartment lymph node metastasis in patients with papillary thyroid cancer. AU - Howell,Gina M, AU - Nikiforova,Marina N, AU - Carty,Sally E, AU - Armstrong,Michaele J, AU - Hodak,Steven P, AU - Stang,Michael T, AU - McCoy,Kelly L, AU - Nikiforov,Yuri E, AU - Yip,Linwah, Y1 - 2012/09/01/ PY - 2012/03/19/received PY - 2012/9/4/entrez PY - 2012/9/4/pubmed PY - 2013/6/13/medline SP - 47 EP - 52 JF - Annals of surgical oncology JO - Ann. Surg. Oncol. VL - 20 IS - 1 N2 - PURPOSE: This study was designed to examine whether available preoperative clinical parameters, including B-type Raf kinase (BRAF) V600E mutation status, can identify patients at risk for central compartment lymph node metastasis (CLNM). METHODS: Under an institutional review board-approved protocol, we conducted a single-center, retrospective review of all patients who had initial thyroidectomy for histologic papillary thyroid carcinoma (PTC) during 2010. The presence of CLNM was examined for correlation with available preoperative clinical parameters, including tumor size, gender, age, and BRAF mutation status. RESULTS: Cervical lymph node resection and molecular testing on FNAB or histopathologic specimen was performed on a consecutive series of 156 study patients with histologic PTC. Overall, CLNM was diagnosed in 37% and 46% were BRAF-mutation-positive. BRAF positivity was the only clinical parameter associated with CLNM (BRAF, p=0.002; tumor size≥2 cm, p=0.16; male gender, p=0.1; age≥45 years, p=0.3) and remained an independent predictor of CLNM on multiple logistic regression analysis (odds ratio (OR) 3.2, p=0.001). The PPV and NPV of BRAF positivity for CLNM was 50 and 74%, respectively. When restricting the analysis to the subset of 38 patients who had molecular testing performed preoperatively on FNAB, the PPV and NPV of BRAF positivity for CLNM was 47 and 91%, respectively, and BRAF positivity was still a significant predictor of CLNM on both univariate (OR 8.4, p=0.01) and multivariate (OR 9.7, p=0.02) analyses. CONCLUSIONS: Of the commonly used clinical parameters available preoperatively, the BRAF V600E mutation is the only independent predictor of CLNM in PTC and can be utilized to guide the extent of initial surgery. SN - 1534-4681 UR - https://www.unboundmedicine.com/medline/citation/22941165/BRAF_V600E_mutation_independently_predicts_central_compartment_lymph_node_metastasis_in_patients_with_papillary_thyroid_cancer_ L2 - https://dx.doi.org/10.1245/s10434-012-2611-0 DB - PRIME DP - Unbound Medicine ER -