Tags

Type your tag names separated by a space and hit enter

Maternal use of folic acid and other supplements and risk of childhood brain tumors.
Cancer Epidemiol Biomarkers Prev. 2012 Nov; 21(11):1933-41.CE

Abstract

BACKGROUND

Interest in a possible protective effect of maternal vitamin use before or during pregnancy against childhood brain tumors (CBT) and other childhood cancers has grown over the past decade. Our Australian study of CBTs, conducted between 2005 and 2011, investigated whether maternal use folic acid and other supplements was protective.

METHODS

Case children were identified through the 10 Australian pediatric oncology centers and controls were recruited by national random digit dialing. Mothers of 327 cases and 867 control children provided information on supplement use before and during the index pregnancy, including brand name, dose, and timing. Data were analyzed using multivariable unconditional logistic regression.

RESULTS

The OR for any maternal use of folic acid, use of folic acid without iron or vitamins B6, B12, C, or A, and any vitamin use before pregnancy, were: 0.68 [95% confidence interval (CI), 0.46-1.00; 0.55 (95% CI, 0.32-0.93) and 0.68 (95% CI, 0.46-1.01), respectively. The ORs for use of these supplements during pregnancy were also below unity, but generally closer to the null than those for the prepregnancy period. There was some evidence of an inverse dose-response during each time period.

CONCLUSIONS

These results suggest that folic acid supplements before and possibly during pregnancy may protect against CBT. Such associations are biologically plausible through established mechanisms.

IMPACT

This study provides evidence of a specific protective effect of prenatal folic acid supplementation against the risk of CBT that is not attributable to the actions of the other micronutrients investigated.

Authors+Show Affiliations

Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Western Australia 6872, Australia. lizm@ichr.uwa.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22941336

Citation

Milne, Elizabeth, et al. "Maternal Use of Folic Acid and Other Supplements and Risk of Childhood Brain Tumors." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 21, no. 11, 2012, pp. 1933-41.
Milne E, Greenop KR, Bower C, et al. Maternal use of folic acid and other supplements and risk of childhood brain tumors. Cancer Epidemiol Biomarkers Prev. 2012;21(11):1933-41.
Milne, E., Greenop, K. R., Bower, C., Miller, M., van Bockxmeer, F. M., Scott, R. J., de Klerk, N. H., Ashton, L. J., Gottardo, N. G., & Armstrong, B. K. (2012). Maternal use of folic acid and other supplements and risk of childhood brain tumors. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 21(11), 1933-41. https://doi.org/10.1158/1055-9965.EPI-12-0803
Milne E, et al. Maternal Use of Folic Acid and Other Supplements and Risk of Childhood Brain Tumors. Cancer Epidemiol Biomarkers Prev. 2012;21(11):1933-41. PubMed PMID: 22941336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal use of folic acid and other supplements and risk of childhood brain tumors. AU - Milne,Elizabeth, AU - Greenop,Kathryn R, AU - Bower,Carol, AU - Miller,Margaret, AU - van Bockxmeer,Frank M, AU - Scott,Rodney J, AU - de Klerk,Nicholas H, AU - Ashton,Lesley J, AU - Gottardo,Nicholas G, AU - Armstrong,Bruce K, AU - ,, Y1 - 2012/08/31/ PY - 2012/9/4/entrez PY - 2012/9/4/pubmed PY - 2013/7/11/medline SP - 1933 EP - 41 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 21 IS - 11 N2 - BACKGROUND: Interest in a possible protective effect of maternal vitamin use before or during pregnancy against childhood brain tumors (CBT) and other childhood cancers has grown over the past decade. Our Australian study of CBTs, conducted between 2005 and 2011, investigated whether maternal use folic acid and other supplements was protective. METHODS: Case children were identified through the 10 Australian pediatric oncology centers and controls were recruited by national random digit dialing. Mothers of 327 cases and 867 control children provided information on supplement use before and during the index pregnancy, including brand name, dose, and timing. Data were analyzed using multivariable unconditional logistic regression. RESULTS: The OR for any maternal use of folic acid, use of folic acid without iron or vitamins B6, B12, C, or A, and any vitamin use before pregnancy, were: 0.68 [95% confidence interval (CI), 0.46-1.00; 0.55 (95% CI, 0.32-0.93) and 0.68 (95% CI, 0.46-1.01), respectively. The ORs for use of these supplements during pregnancy were also below unity, but generally closer to the null than those for the prepregnancy period. There was some evidence of an inverse dose-response during each time period. CONCLUSIONS: These results suggest that folic acid supplements before and possibly during pregnancy may protect against CBT. Such associations are biologically plausible through established mechanisms. IMPACT: This study provides evidence of a specific protective effect of prenatal folic acid supplementation against the risk of CBT that is not attributable to the actions of the other micronutrients investigated. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/22941336/Maternal_use_of_folic_acid_and_other_supplements_and_risk_of_childhood_brain_tumors_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=22941336 DB - PRIME DP - Unbound Medicine ER -