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Acetazolamide for the prevention of acute mountain sickness--a systematic review and meta-analysis.
J Travel Med 2012 Sep-Oct; 19(5):298-307JT

Abstract

BACKGROUND

Acetazolamide has been reported to be effective in the prevention of acute mountain sickness (AMS). Our aim was to conduct a systematic review of randomized, placebo-controlled trials of acetazolamide in the prevention of AMS.

METHODS

Studies were identified by searching the MEDLINE, Embase, Cochrane Clinical Trials Register, and ClinicalTrials.gov databases. Primary end point was difference in incidence of AMS between acetazolamide and placebo groups.

RESULTS

Acetazolamide prophylaxis was associated with a 48% relative-risk reduction compared to placebo. There was no evidence of an association between efficacy and dose of acetazolamide. Adverse effects were often not systematically reported but appeared to be common but generally mild. One study found that adverse effects of acetazolamide were dose related.

CONCLUSIONS

Acetazolamide is effective prophylaxis for the prevention of symptoms of AMS in those going to high altitude. A dose of 250 mg/day has similar efficacy to higher doses and may have a favorable side-effect profile.

Authors+Show Affiliations

Institute of Infection, Immunity and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK. Neil.Ritchie@Glasgow.ac.ukNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

22943270

Citation

Ritchie, Neil D., et al. "Acetazolamide for the Prevention of Acute Mountain Sickness--a Systematic Review and Meta-analysis." Journal of Travel Medicine, vol. 19, no. 5, 2012, pp. 298-307.
Ritchie ND, Baggott AV, Andrew Todd WT. Acetazolamide for the prevention of acute mountain sickness--a systematic review and meta-analysis. J Travel Med. 2012;19(5):298-307.
Ritchie, N. D., Baggott, A. V., & Andrew Todd, W. T. (2012). Acetazolamide for the prevention of acute mountain sickness--a systematic review and meta-analysis. Journal of Travel Medicine, 19(5), pp. 298-307. doi:10.1111/j.1708-8305.2012.00629.x.
Ritchie ND, Baggott AV, Andrew Todd WT. Acetazolamide for the Prevention of Acute Mountain Sickness--a Systematic Review and Meta-analysis. J Travel Med. 2012;19(5):298-307. PubMed PMID: 22943270.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acetazolamide for the prevention of acute mountain sickness--a systematic review and meta-analysis. AU - Ritchie,Neil D, AU - Baggott,Amy V, AU - Andrew Todd,W T, Y1 - 2012/07/30/ PY - 2012/01/09/received PY - 2012/03/22/revised PY - 2012/03/26/accepted PY - 2012/9/5/entrez PY - 2012/9/5/pubmed PY - 2013/1/17/medline SP - 298 EP - 307 JF - Journal of travel medicine JO - J Travel Med VL - 19 IS - 5 N2 - BACKGROUND: Acetazolamide has been reported to be effective in the prevention of acute mountain sickness (AMS). Our aim was to conduct a systematic review of randomized, placebo-controlled trials of acetazolamide in the prevention of AMS. METHODS: Studies were identified by searching the MEDLINE, Embase, Cochrane Clinical Trials Register, and ClinicalTrials.gov databases. Primary end point was difference in incidence of AMS between acetazolamide and placebo groups. RESULTS: Acetazolamide prophylaxis was associated with a 48% relative-risk reduction compared to placebo. There was no evidence of an association between efficacy and dose of acetazolamide. Adverse effects were often not systematically reported but appeared to be common but generally mild. One study found that adverse effects of acetazolamide were dose related. CONCLUSIONS: Acetazolamide is effective prophylaxis for the prevention of symptoms of AMS in those going to high altitude. A dose of 250 mg/day has similar efficacy to higher doses and may have a favorable side-effect profile. SN - 1708-8305 UR - https://www.unboundmedicine.com/medline/citation/22943270/full_citation L2 - https://academic.oup.com/jtm/article-lookup/doi/10.1111/j.1708-8305.2012.00629.x DB - PRIME DP - Unbound Medicine ER -