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The efficacy of gabapentin versus stabilization splint in management of sleep bruxism.
J Prosthodont. 2013 Feb; 22(2):126-31.JP

Abstract

PURPOSE

This study aimed to determine if the use of gabapentin is more efficacious than a stabilization splint with regard to the intensity of masseter muscle contractions and/or sleep quality for patients experiencing sleep bruxism (SB).

MATERIALS AND METHODS

Twenty patients with SB participated in this clinical study. They were randomly divided into two treatment groups: stabilization splint group (n = 10) and gabapentin group (n = 10). The first polysomnographic examination was performed before the beginning of the experiment for all the participants. At the end of a 2-month period of stabilization splint therapy or gabapentin usage, a second polysomnographic recording was made.

RESULTS

Statistically significant reductions in the number of SB episodes per hour and per night, bruxism time index, total duration of SB episodes per night and number of SB episodes in stages NR I and NR II (p < 0.05) were observed in both groups after treatment. Both treatments significantly reduced the mean intensity of masseter muscle contractions during SB episodes. Moreover, the participants treated with gabapentin showed a significant improvement in total sleep time, slow wave sleep (stage III), and sleep efficiency (p < 0.05).

CONCLUSIONS

Gabapentin could be an effective treatment modality in SBs, especially in those with poor sleep quality.

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Authors+Show Affiliations

Madani AS
Dental Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Abdollahian E
No affiliation info available
Khiavi HA
No affiliation info available
Radvar M
No affiliation info available
Foroughipour M
No affiliation info available
Asadpour H
No affiliation info available
Hasanzadeh N
No affiliation info available

MeSH

AdolescentAdultAminesCentric RelationCyclohexanecarboxylic AcidsExcitatory Amino Acid AntagonistsFemaleFollow-Up StudiesGabapentinHumansMaleMasseter MuscleMiddle AgedMuscle ContractionOcclusal SplintsOrthodontic Appliance DesignPolysomnographySingle-Blind MethodSleepSleep BruxismSleep StagesTreatment OutcomeYoung Adultgamma-Aminobutyric Acid

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22946979

Citation

Madani, Azam Sadat, et al. "The Efficacy of Gabapentin Versus Stabilization Splint in Management of Sleep Bruxism." Journal of Prosthodontics : Official Journal of the American College of Prosthodontists, vol. 22, no. 2, 2013, pp. 126-31.
Madani AS, Abdollahian E, Khiavi HA, et al. The efficacy of gabapentin versus stabilization splint in management of sleep bruxism. J Prosthodont. 2013;22(2):126-31.
Madani, A. S., Abdollahian, E., Khiavi, H. A., Radvar, M., Foroughipour, M., Asadpour, H., & Hasanzadeh, N. (2013). The efficacy of gabapentin versus stabilization splint in management of sleep bruxism. Journal of Prosthodontics : Official Journal of the American College of Prosthodontists, 22(2), 126-31. https://doi.org/10.1111/j.1532-849X.2012.00914.x
Madani AS, et al. The Efficacy of Gabapentin Versus Stabilization Splint in Management of Sleep Bruxism. J Prosthodont. 2013;22(2):126-31. PubMed PMID: 22946979.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The efficacy of gabapentin versus stabilization splint in management of sleep bruxism. AU - Madani,Azam Sadat, AU - Abdollahian,Ebrahim, AU - Khiavi,Hasan Azangoo, AU - Radvar,Mehrdad, AU - Foroughipour,Mohsen, AU - Asadpour,Hadi, AU - Hasanzadeh,Nadia, Y1 - 2012/09/04/ PY - 2012/9/6/entrez PY - 2012/9/6/pubmed PY - 2014/5/21/medline SP - 126 EP - 31 JF - Journal of prosthodontics : official journal of the American College of Prosthodontists JO - J Prosthodont VL - 22 IS - 2 N2 - PURPOSE: This study aimed to determine if the use of gabapentin is more efficacious than a stabilization splint with regard to the intensity of masseter muscle contractions and/or sleep quality for patients experiencing sleep bruxism (SB). MATERIALS AND METHODS: Twenty patients with SB participated in this clinical study. They were randomly divided into two treatment groups: stabilization splint group (n = 10) and gabapentin group (n = 10). The first polysomnographic examination was performed before the beginning of the experiment for all the participants. At the end of a 2-month period of stabilization splint therapy or gabapentin usage, a second polysomnographic recording was made. RESULTS: Statistically significant reductions in the number of SB episodes per hour and per night, bruxism time index, total duration of SB episodes per night and number of SB episodes in stages NR I and NR II (p < 0.05) were observed in both groups after treatment. Both treatments significantly reduced the mean intensity of masseter muscle contractions during SB episodes. Moreover, the participants treated with gabapentin showed a significant improvement in total sleep time, slow wave sleep (stage III), and sleep efficiency (p < 0.05). CONCLUSIONS: Gabapentin could be an effective treatment modality in SBs, especially in those with poor sleep quality. SN - 1532-849X UR - https://www.unboundmedicine.com/medline/citation/22946979/The_efficacy_of_gabapentin_versus_stabilization_splint_in_management_of_sleep_bruxism_ L2 - https://doi.org/10.1111/j.1532-849X.2012.00914.x DB - PRIME DP - Unbound Medicine ER -