TY - JOUR T1 - Synthesis and biological evaluation of a novel series of chalcones incorporated pyrazole moiety as anticancer and antimicrobial agents. AU - Mohamed,Magda F, AU - Mohamed,Mervat S, AU - Shouman,Samia A, AU - Fathi,Mohamed M, AU - Abdelhamid,Ismail Abdelshafy, Y1 - 2012/09/05/ PY - 2012/01/23/received PY - 2012/08/15/accepted PY - 2012/9/6/entrez PY - 2012/9/6/pubmed PY - 2013/6/1/medline SP - 1153 EP - 62 JF - Applied biochemistry and biotechnology JO - Appl Biochem Biotechnol VL - 168 IS - 5 N2 - A newly synthesized series of chalcone derivatives containing pyrazole rings were synthesized and evaluated for their cytotoxic activities in vitro against several human cancer cell lines. Most of the prepared compounds showed potential cytotoxicity against human breast cancer cell lines MCF-7, HEPG-2, and HCT-116. Also the compounds were evaluated as antimicrobial agents. The three compounds 3, 4, and 5 were proved to be better anticancer agents than the positive standard doxorubicin with IC50 values (4.7, 4.4, and 3.9 μg/ml) against the same human cancer cell lines, whereas compounds 5 and 6 showed the most active antimicrobial compounds in comparison to the other chalcones. SN - 1559-0291 UR - https://www.unboundmedicine.com/medline/citation/22948604/Synthesis_and_biological_evaluation_of_a_novel_series_of_chalcones_incorporated_pyrazole_moiety_as_anticancer_and_antimicrobial_agents_ L2 - https://dx.doi.org/10.1007/s12010-012-9848-8 DB - PRIME DP - Unbound Medicine ER -