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Omega-3 fatty acid-derived mediator, Resolvin E1, ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis in NC/Nga mice.
Int Immunopharmacol. 2012 Dec; 14(4):384-91.II

Abstract

Atopic dermatitis (AD) is a common inflammatory skin disease for which few effective treatments are available. Resolvin E1 (RvE1; 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid) is an endogenous lipid mediator derived from omega-3 fatty eicosapentaenoic acid, which is a potent inhibitor of inflammation. AD-like skin lesion was induced by repetitive skin contact with DNFB in NC/Nga mice and the effects of RvE1 were evaluated on the basis of histopathological findings of skin, ear swelling and cytokine production of CD4(+) T cells. Intraperitoneal injection of RvE1 for one week after DNFB challenge significantly lowered ear swelling and improved back skin lesions. In addition, RvE1 significantly suppressed production of interferon-gamma (IFN-γ) and interleukin-4 (IL-4) by activated CD4(+) T cells and serum IgE level. Furthermore, RvE1 reduced DNFB-induced infiltration of eosinophils, mast cells, CD4(+) T cells, and CD8(+) T cells in skin lesions. Therefore, RvE1 may suppress the development of AD-like skin lesions in DNFB-treated NC/Nga mice by reducing IL-4 and IFN-γ of activated CD4(+) T cells and serum IgE levels and infiltration of immune cells to skin lesion.

Authors+Show Affiliations

Department of Microbiology (BK21), School of Medicine, Kyung Hee University, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22951188

Citation

Kim, Tae-Ho, et al. "Omega-3 Fatty Acid-derived Mediator, Resolvin E1, Ameliorates 2,4-dinitrofluorobenzene-induced Atopic Dermatitis in NC/Nga Mice." International Immunopharmacology, vol. 14, no. 4, 2012, pp. 384-91.
Kim TH, Kim GD, Jin YH, et al. Omega-3 fatty acid-derived mediator, Resolvin E1, ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis in NC/Nga mice. Int Immunopharmacol. 2012;14(4):384-91.
Kim, T. H., Kim, G. D., Jin, Y. H., Park, Y. S., & Park, C. S. (2012). Omega-3 fatty acid-derived mediator, Resolvin E1, ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis in NC/Nga mice. International Immunopharmacology, 14(4), 384-91. https://doi.org/10.1016/j.intimp.2012.08.005
Kim TH, et al. Omega-3 Fatty Acid-derived Mediator, Resolvin E1, Ameliorates 2,4-dinitrofluorobenzene-induced Atopic Dermatitis in NC/Nga Mice. Int Immunopharmacol. 2012;14(4):384-91. PubMed PMID: 22951188.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 fatty acid-derived mediator, Resolvin E1, ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis in NC/Nga mice. AU - Kim,Tae-Ho, AU - Kim,Gun-Dong, AU - Jin,Young-Ho, AU - Park,Yong Seek, AU - Park,Cheung-Seog, Y1 - 2012/08/27/ PY - 2012/06/08/received PY - 2012/07/13/revised PY - 2012/08/05/accepted PY - 2012/9/7/entrez PY - 2012/9/7/pubmed PY - 2013/6/5/medline SP - 384 EP - 91 JF - International immunopharmacology JO - Int Immunopharmacol VL - 14 IS - 4 N2 - Atopic dermatitis (AD) is a common inflammatory skin disease for which few effective treatments are available. Resolvin E1 (RvE1; 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid) is an endogenous lipid mediator derived from omega-3 fatty eicosapentaenoic acid, which is a potent inhibitor of inflammation. AD-like skin lesion was induced by repetitive skin contact with DNFB in NC/Nga mice and the effects of RvE1 were evaluated on the basis of histopathological findings of skin, ear swelling and cytokine production of CD4(+) T cells. Intraperitoneal injection of RvE1 for one week after DNFB challenge significantly lowered ear swelling and improved back skin lesions. In addition, RvE1 significantly suppressed production of interferon-gamma (IFN-γ) and interleukin-4 (IL-4) by activated CD4(+) T cells and serum IgE level. Furthermore, RvE1 reduced DNFB-induced infiltration of eosinophils, mast cells, CD4(+) T cells, and CD8(+) T cells in skin lesions. Therefore, RvE1 may suppress the development of AD-like skin lesions in DNFB-treated NC/Nga mice by reducing IL-4 and IFN-γ of activated CD4(+) T cells and serum IgE levels and infiltration of immune cells to skin lesion. SN - 1878-1705 UR - https://www.unboundmedicine.com/medline/citation/22951188/Omega_3_fatty_acid_derived_mediator_Resolvin_E1_ameliorates_24_dinitrofluorobenzene_induced_atopic_dermatitis_in_NC/Nga_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(12)00245-7 DB - PRIME DP - Unbound Medicine ER -