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Choline intake and risk of lethal prostate cancer: incidence and survival.

Abstract

BACKGROUND

Meat, milk, and eggs have been inconsistently associated with the risk of advanced prostate cancer. These foods are sources of choline-a nutrient that may affect prostate cancer progression through cell membrane function and one-carbon metabolism. No study has examined dietary choline and the risk of lethal prostate cancer.

OBJECTIVE

Our objective was to examine whether dietary choline, choline-containing compounds, and betaine (a choline metabolite) increase the risk of lethal prostate cancer.

DESIGN

We prospectively examined the intake of these nutrients and the risk of lethal prostate cancer among 47,896 men in the Health Professionals Follow-Up Study. In a case-only survival analysis, we examined the postdiagnostic intake of these nutrients and the risk of lethal prostate cancer among 4282 men with an initial diagnosis of nonmetastatic disease during follow-up. Diet was assessed with a validated questionnaire 6 times during 22 y of follow-up.

RESULTS

In the incidence analysis, we observed 695 lethal prostate cancers during 879,627 person-years. Men in the highest quintile of choline intake had a 70% increased risk of lethal prostate cancer (HR: 1.70; 95% CI: 1.18, 2.45; P-trend = 0.005). In the case-only survival analysis, we observed 271 lethal cases during 33,679 person-years. Postdiagnostic choline intake was not statistically significantly associated with the risk of lethal prostate cancer (HR for quintile 5 compared with quintile 1: 1.69; 95% CI: 0.93, 3.09; P-trend = 0.20).

CONCLUSION

Of the 47,896 men in our study population, choline intake was associated with an increased risk of lethal prostate cancer.

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  • Authors+Show Affiliations

    ,

    Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA, USA. richmane@urology.ucsf.edu

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    Source

    MeSH

    Adult
    Aged
    Betaine
    Choline
    Cohort Studies
    Diet
    Disease Progression
    Follow-Up Studies
    Health Personnel
    Humans
    Incidence
    Male
    Middle Aged
    Phosphatidylcholines
    Phosphorylcholine
    Prospective Studies
    Prostatic Neoplasms
    Risk
    Sphingomyelins
    Survival Analysis
    United States

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    22952174

    Citation

    Richman, Erin L., et al. "Choline Intake and Risk of Lethal Prostate Cancer: Incidence and Survival." The American Journal of Clinical Nutrition, vol. 96, no. 4, 2012, pp. 855-63.
    Richman EL, Kenfield SA, Stampfer MJ, et al. Choline intake and risk of lethal prostate cancer: incidence and survival. Am J Clin Nutr. 2012;96(4):855-63.
    Richman, E. L., Kenfield, S. A., Stampfer, M. J., Giovannucci, E. L., Zeisel, S. H., Willett, W. C., & Chan, J. M. (2012). Choline intake and risk of lethal prostate cancer: incidence and survival. The American Journal of Clinical Nutrition, 96(4), pp. 855-63.
    Richman EL, et al. Choline Intake and Risk of Lethal Prostate Cancer: Incidence and Survival. Am J Clin Nutr. 2012;96(4):855-63. PubMed PMID: 22952174.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Choline intake and risk of lethal prostate cancer: incidence and survival. AU - Richman,Erin L, AU - Kenfield,Stacey A, AU - Stampfer,Meir J, AU - Giovannucci,Edward L, AU - Zeisel,Steven H, AU - Willett,Walter C, AU - Chan,June M, Y1 - 2012/09/05/ PY - 2012/9/7/entrez PY - 2012/9/7/pubmed PY - 2012/12/12/medline SP - 855 EP - 63 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 96 IS - 4 N2 - BACKGROUND: Meat, milk, and eggs have been inconsistently associated with the risk of advanced prostate cancer. These foods are sources of choline-a nutrient that may affect prostate cancer progression through cell membrane function and one-carbon metabolism. No study has examined dietary choline and the risk of lethal prostate cancer. OBJECTIVE: Our objective was to examine whether dietary choline, choline-containing compounds, and betaine (a choline metabolite) increase the risk of lethal prostate cancer. DESIGN: We prospectively examined the intake of these nutrients and the risk of lethal prostate cancer among 47,896 men in the Health Professionals Follow-Up Study. In a case-only survival analysis, we examined the postdiagnostic intake of these nutrients and the risk of lethal prostate cancer among 4282 men with an initial diagnosis of nonmetastatic disease during follow-up. Diet was assessed with a validated questionnaire 6 times during 22 y of follow-up. RESULTS: In the incidence analysis, we observed 695 lethal prostate cancers during 879,627 person-years. Men in the highest quintile of choline intake had a 70% increased risk of lethal prostate cancer (HR: 1.70; 95% CI: 1.18, 2.45; P-trend = 0.005). In the case-only survival analysis, we observed 271 lethal cases during 33,679 person-years. Postdiagnostic choline intake was not statistically significantly associated with the risk of lethal prostate cancer (HR for quintile 5 compared with quintile 1: 1.69; 95% CI: 0.93, 3.09; P-trend = 0.20). CONCLUSION: Of the 47,896 men in our study population, choline intake was associated with an increased risk of lethal prostate cancer. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22952174/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.112.039784 DB - PRIME DP - Unbound Medicine ER -