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Choline intake and risk of lethal prostate cancer: incidence and survival.
Am J Clin Nutr 2012; 96(4):855-63AJ

Abstract

BACKGROUND

Meat, milk, and eggs have been inconsistently associated with the risk of advanced prostate cancer. These foods are sources of choline-a nutrient that may affect prostate cancer progression through cell membrane function and one-carbon metabolism. No study has examined dietary choline and the risk of lethal prostate cancer.

OBJECTIVE

Our objective was to examine whether dietary choline, choline-containing compounds, and betaine (a choline metabolite) increase the risk of lethal prostate cancer.

DESIGN

We prospectively examined the intake of these nutrients and the risk of lethal prostate cancer among 47,896 men in the Health Professionals Follow-Up Study. In a case-only survival analysis, we examined the postdiagnostic intake of these nutrients and the risk of lethal prostate cancer among 4282 men with an initial diagnosis of nonmetastatic disease during follow-up. Diet was assessed with a validated questionnaire 6 times during 22 y of follow-up.

RESULTS

In the incidence analysis, we observed 695 lethal prostate cancers during 879,627 person-years. Men in the highest quintile of choline intake had a 70% increased risk of lethal prostate cancer (HR: 1.70; 95% CI: 1.18, 2.45; P-trend = 0.005). In the case-only survival analysis, we observed 271 lethal cases during 33,679 person-years. Postdiagnostic choline intake was not statistically significantly associated with the risk of lethal prostate cancer (HR for quintile 5 compared with quintile 1: 1.69; 95% CI: 0.93, 3.09; P-trend = 0.20).

CONCLUSION

Of the 47,896 men in our study population, choline intake was associated with an increased risk of lethal prostate cancer.

Authors+Show Affiliations

Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA, USA. richmane@urology.ucsf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22952174

Citation

Richman, Erin L., et al. "Choline Intake and Risk of Lethal Prostate Cancer: Incidence and Survival." The American Journal of Clinical Nutrition, vol. 96, no. 4, 2012, pp. 855-63.
Richman EL, Kenfield SA, Stampfer MJ, et al. Choline intake and risk of lethal prostate cancer: incidence and survival. Am J Clin Nutr. 2012;96(4):855-63.
Richman, E. L., Kenfield, S. A., Stampfer, M. J., Giovannucci, E. L., Zeisel, S. H., Willett, W. C., & Chan, J. M. (2012). Choline intake and risk of lethal prostate cancer: incidence and survival. The American Journal of Clinical Nutrition, 96(4), pp. 855-63.
Richman EL, et al. Choline Intake and Risk of Lethal Prostate Cancer: Incidence and Survival. Am J Clin Nutr. 2012;96(4):855-63. PubMed PMID: 22952174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Choline intake and risk of lethal prostate cancer: incidence and survival. AU - Richman,Erin L, AU - Kenfield,Stacey A, AU - Stampfer,Meir J, AU - Giovannucci,Edward L, AU - Zeisel,Steven H, AU - Willett,Walter C, AU - Chan,June M, Y1 - 2012/09/05/ PY - 2012/9/7/entrez PY - 2012/9/7/pubmed PY - 2012/12/12/medline SP - 855 EP - 63 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 96 IS - 4 N2 - BACKGROUND: Meat, milk, and eggs have been inconsistently associated with the risk of advanced prostate cancer. These foods are sources of choline-a nutrient that may affect prostate cancer progression through cell membrane function and one-carbon metabolism. No study has examined dietary choline and the risk of lethal prostate cancer. OBJECTIVE: Our objective was to examine whether dietary choline, choline-containing compounds, and betaine (a choline metabolite) increase the risk of lethal prostate cancer. DESIGN: We prospectively examined the intake of these nutrients and the risk of lethal prostate cancer among 47,896 men in the Health Professionals Follow-Up Study. In a case-only survival analysis, we examined the postdiagnostic intake of these nutrients and the risk of lethal prostate cancer among 4282 men with an initial diagnosis of nonmetastatic disease during follow-up. Diet was assessed with a validated questionnaire 6 times during 22 y of follow-up. RESULTS: In the incidence analysis, we observed 695 lethal prostate cancers during 879,627 person-years. Men in the highest quintile of choline intake had a 70% increased risk of lethal prostate cancer (HR: 1.70; 95% CI: 1.18, 2.45; P-trend = 0.005). In the case-only survival analysis, we observed 271 lethal cases during 33,679 person-years. Postdiagnostic choline intake was not statistically significantly associated with the risk of lethal prostate cancer (HR for quintile 5 compared with quintile 1: 1.69; 95% CI: 0.93, 3.09; P-trend = 0.20). CONCLUSION: Of the 47,896 men in our study population, choline intake was associated with an increased risk of lethal prostate cancer. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22952174/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.112.039784 DB - PRIME DP - Unbound Medicine ER -