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Plasma and dietary omega-3 fatty acids, fish intake, and heart failure risk in the Physicians' Health Study.

Abstract

BACKGROUND

Data on the relation of plasma and dietary omega-3 (n-3) fatty acids (FAs) with heart failure (HF) risk have been inconsistent.

OBJECTIVE

We evaluated the relation of n-3 FAs with HF in US male physicians.

DESIGN

We used nested case-control (n = 1572) and prospective cohort study designs (n = 19,097). Plasma phospholipid n-3 FAs were measured by using gas chromatography, and food-frequency questionnaires were used to assess dietary n-3 FAs and fish intake. Incident HF was ascertained via annual follow-up questionnaires and validated in a subsample.

RESULTS

The mean age was 58.7 y at blood collection. In a multivariable model, plasma α-linolenic acid (ALA) was associated with a lower risk of HF in a nonlinear fashion (P-quadratic trend = 0.02), and the lowest OR was observed in quintile 4 (0.66; 95% CI: 0.47, 0.94). Plasma EPA and DHA were not associated with HF, whereas plasma docosapentaenoic acid (DPA) showed a nonlinear inverse relation with HF for quintile 2 (OR: 0.55; 95% CI: 0.39, 0.79). Dietary marine n-3 FAs showed a trend toward a lower risk of HF in quintile 4 (HR: 0.81; 95% CI: 0.64, 1.02) and a nonlinear pattern across quintiles. Fish intake was associated with a lower risk of HF, with RRs of ~0.70 for all categories of fish consumption greater than one serving per month.

CONCLUSIONS

Our data are consistent with an inverse and nonlinear relation of plasma phospholipid ALA and DPA, but not EPA or DHA, with HF risk. Fish consumption greater than once per month was associated with a lower HF risk.

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  • Authors+Show Affiliations

    ,

    Divisions of Aging and Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02120, USA.

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    Source

    MeSH

    Aged
    Animals
    Case-Control Studies
    Cohort Studies
    Diet
    Double-Blind Method
    Fatty Acids, Omega-3
    Fatty Acids, Unsaturated
    Female
    Fishes
    Follow-Up Studies
    Heart Failure
    Humans
    Incidence
    Male
    Middle Aged
    Physicians
    Risk
    Seafood
    United States
    alpha-Linolenic Acid

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    22952185

    Citation

    Wilk, Jemma B., et al. "Plasma and Dietary Omega-3 Fatty Acids, Fish Intake, and Heart Failure Risk in the Physicians' Health Study." The American Journal of Clinical Nutrition, vol. 96, no. 4, 2012, pp. 882-8.
    Wilk JB, Tsai MY, Hanson NQ, et al. Plasma and dietary omega-3 fatty acids, fish intake, and heart failure risk in the Physicians' Health Study. Am J Clin Nutr. 2012;96(4):882-8.
    Wilk, J. B., Tsai, M. Y., Hanson, N. Q., Gaziano, J. M., & Djoussé, L. (2012). Plasma and dietary omega-3 fatty acids, fish intake, and heart failure risk in the Physicians' Health Study. The American Journal of Clinical Nutrition, 96(4), pp. 882-8.
    Wilk JB, et al. Plasma and Dietary Omega-3 Fatty Acids, Fish Intake, and Heart Failure Risk in the Physicians' Health Study. Am J Clin Nutr. 2012;96(4):882-8. PubMed PMID: 22952185.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Plasma and dietary omega-3 fatty acids, fish intake, and heart failure risk in the Physicians' Health Study. AU - Wilk,Jemma B, AU - Tsai,Michael Y, AU - Hanson,Naomi Q, AU - Gaziano,J Michael, AU - Djoussé,Luc, Y1 - 2012/09/05/ PY - 2012/9/7/entrez PY - 2012/9/7/pubmed PY - 2012/12/12/medline SP - 882 EP - 8 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 96 IS - 4 N2 - BACKGROUND: Data on the relation of plasma and dietary omega-3 (n-3) fatty acids (FAs) with heart failure (HF) risk have been inconsistent. OBJECTIVE: We evaluated the relation of n-3 FAs with HF in US male physicians. DESIGN: We used nested case-control (n = 1572) and prospective cohort study designs (n = 19,097). Plasma phospholipid n-3 FAs were measured by using gas chromatography, and food-frequency questionnaires were used to assess dietary n-3 FAs and fish intake. Incident HF was ascertained via annual follow-up questionnaires and validated in a subsample. RESULTS: The mean age was 58.7 y at blood collection. In a multivariable model, plasma α-linolenic acid (ALA) was associated with a lower risk of HF in a nonlinear fashion (P-quadratic trend = 0.02), and the lowest OR was observed in quintile 4 (0.66; 95% CI: 0.47, 0.94). Plasma EPA and DHA were not associated with HF, whereas plasma docosapentaenoic acid (DPA) showed a nonlinear inverse relation with HF for quintile 2 (OR: 0.55; 95% CI: 0.39, 0.79). Dietary marine n-3 FAs showed a trend toward a lower risk of HF in quintile 4 (HR: 0.81; 95% CI: 0.64, 1.02) and a nonlinear pattern across quintiles. Fish intake was associated with a lower risk of HF, with RRs of ~0.70 for all categories of fish consumption greater than one serving per month. CONCLUSIONS: Our data are consistent with an inverse and nonlinear relation of plasma phospholipid ALA and DPA, but not EPA or DHA, with HF risk. Fish consumption greater than once per month was associated with a lower HF risk. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22952185/Plasma_and_dietary_omega_3_fatty_acids_fish_intake_and_heart_failure_risk_in_the_Physicians'_Health_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.112.042671 DB - PRIME DP - Unbound Medicine ER -