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Theory and practical application of superficial atypical melanocytic proliferations of uncertain significance (SAMPUS) and melanocytic tumours of uncertain malignant potential (MELTUMP) terminology: experience with second opinion consultation.
Pathologica. 2012 Apr; 104(2):70-7.P

Abstract

INTRODUCTION

The term superficial atypical melanocytic proliferations of uncertain significance (SAMPUS) is used to resolve discordance in diagnosis of "thin" melanocytic lesions. Melanocytic tumours of uncertain malignant potential (MELTUMP) is the descriptive term for an ill-defined group of dermal melanocytic tumours that exhibit features indicative of possible malignancy. We report our experience of collaboration with two leading international consultant pathologists in the diagnosis of melanoma in order to facilitate the practical application of the term SAMPUS and MELTUMP.

METHODS

Twenty-seven cases of melanocytic lesions with interpretative problems were sent for consultation to Expert #1 (15 cases) and Expert #2 (12 cases).

RESULTS

Two cases of MELTUMP and two cases of SAMPUS were diagnosed by Expert #1; three cases of MELTUMP and two cases of SAMPUS were diagnosed by Expert #2. Diagnosis was performed with H&E and molecular studies were not performed.

DISCUSSION

Both experts included MELTUMP or SAMPUS atypical, ambiguous melanocytic lesions and melanomas. The diagnosis of SAMPUS and MELTUMP by consultant pathologists reflects the difficulty of classification with accuracy lesions that showed histological features of various atypical tumours or malignant melanoma. In these cases, biological potential may be established with molecular studies.

Authors+Show Affiliations

Institute of Anatomic Pathology, Rovereto Hospital, Italy. teresa.pusiol@apss.tn.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22953503

Citation

Pusiol, T, et al. "Theory and Practical Application of Superficial Atypical Melanocytic Proliferations of Uncertain Significance (SAMPUS) and Melanocytic Tumours of Uncertain Malignant Potential (MELTUMP) Terminology: Experience With Second Opinion Consultation." Pathologica, vol. 104, no. 2, 2012, pp. 70-7.
Pusiol T, Morichetti D, Piscioli F, et al. Theory and practical application of superficial atypical melanocytic proliferations of uncertain significance (SAMPUS) and melanocytic tumours of uncertain malignant potential (MELTUMP) terminology: experience with second opinion consultation. Pathologica. 2012;104(2):70-7.
Pusiol, T., Morichetti, D., Piscioli, F., & Zorzi, M. G. (2012). Theory and practical application of superficial atypical melanocytic proliferations of uncertain significance (SAMPUS) and melanocytic tumours of uncertain malignant potential (MELTUMP) terminology: experience with second opinion consultation. Pathologica, 104(2), 70-7.
Pusiol T, et al. Theory and Practical Application of Superficial Atypical Melanocytic Proliferations of Uncertain Significance (SAMPUS) and Melanocytic Tumours of Uncertain Malignant Potential (MELTUMP) Terminology: Experience With Second Opinion Consultation. Pathologica. 2012;104(2):70-7. PubMed PMID: 22953503.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Theory and practical application of superficial atypical melanocytic proliferations of uncertain significance (SAMPUS) and melanocytic tumours of uncertain malignant potential (MELTUMP) terminology: experience with second opinion consultation. AU - Pusiol,T, AU - Morichetti,D, AU - Piscioli,F, AU - Zorzi,M G, PY - 2012/9/8/entrez PY - 2012/9/8/pubmed PY - 2012/10/10/medline SP - 70 EP - 7 JF - Pathologica JO - Pathologica VL - 104 IS - 2 N2 - INTRODUCTION: The term superficial atypical melanocytic proliferations of uncertain significance (SAMPUS) is used to resolve discordance in diagnosis of "thin" melanocytic lesions. Melanocytic tumours of uncertain malignant potential (MELTUMP) is the descriptive term for an ill-defined group of dermal melanocytic tumours that exhibit features indicative of possible malignancy. We report our experience of collaboration with two leading international consultant pathologists in the diagnosis of melanoma in order to facilitate the practical application of the term SAMPUS and MELTUMP. METHODS: Twenty-seven cases of melanocytic lesions with interpretative problems were sent for consultation to Expert #1 (15 cases) and Expert #2 (12 cases). RESULTS: Two cases of MELTUMP and two cases of SAMPUS were diagnosed by Expert #1; three cases of MELTUMP and two cases of SAMPUS were diagnosed by Expert #2. Diagnosis was performed with H&E and molecular studies were not performed. DISCUSSION: Both experts included MELTUMP or SAMPUS atypical, ambiguous melanocytic lesions and melanomas. The diagnosis of SAMPUS and MELTUMP by consultant pathologists reflects the difficulty of classification with accuracy lesions that showed histological features of various atypical tumours or malignant melanoma. In these cases, biological potential may be established with molecular studies. SN - 0031-2983 UR - https://www.unboundmedicine.com/medline/citation/22953503/Theory_and_practical_application_of_superficial_atypical_melanocytic_proliferations_of_uncertain_significance__SAMPUS__and_melanocytic_tumours_of_uncertain_malignant_potential__MELTUMP__terminology:_experience_with_second_opinion_consultation_ L2 - https://medlineplus.gov/skincancer.html DB - PRIME DP - Unbound Medicine ER -