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Antioxidant and α-glucosidase inhibitory phenolics isolated from highbush blueberry flowers.
Food Chem. 2012 Dec 01; 135(3):1929-37.FC

Abstract

Blueberries have been extensively researched, but there are limited studies on other parts of the plant. Here we report the first phytochemical examination of highbush blueberry (Vaccinium corymbosum) flowers, which yielded 21 phenolics. The compounds were identified from extensive NMR and mass spectral analyses and included five caffeic acid (1-5), three coumaric acid (6-8), and two cinnamyl alcohol (9-10) derivatives, eight flavonol glycosides (11-18), and three phenylpropanoid-substituted catechins (19-21). The isolates were evaluated for antioxidant and α-glucosidase inhibitory activities. Overall, the flavonol glycosides and phenylpropanoid-substituted catechins showed superior antioxidant activities compared to the positive controls, vitamin C (IC(50)=63μM) and butylated hydroxytoluene (IC(50)=1548μM). Similarly, these phenolic sub-classes were more potent α-glucosidase inhibitors than the clinical drug, acarbose (IC(50)=200μM). Thus, non-consumed parts of food plants may be exploited as sources of bioactive compounds beyond their edible parts alone for nutraceutical and functional food applications.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Wan C
Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, United States.
Yuan T
No affiliation info available
Cirello AL
No affiliation info available
Seeram NP
No affiliation info available

MeSH

AntioxidantsBlueberry PlantsEnzyme InhibitorsFlowersGlycoside Hydrolase InhibitorsMolecular StructurePhenolsPlant Extractsalpha-Glucosidases

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22953942

Citation

Wan, Chunpeng, et al. "Antioxidant and Α-glucosidase Inhibitory Phenolics Isolated From Highbush Blueberry Flowers." Food Chemistry, vol. 135, no. 3, 2012, pp. 1929-37.
Wan C, Yuan T, Cirello AL, et al. Antioxidant and α-glucosidase inhibitory phenolics isolated from highbush blueberry flowers. Food Chem. 2012;135(3):1929-37.
Wan, C., Yuan, T., Cirello, A. L., & Seeram, N. P. (2012). Antioxidant and α-glucosidase inhibitory phenolics isolated from highbush blueberry flowers. Food Chemistry, 135(3), 1929-37. https://doi.org/10.1016/j.foodchem.2012.06.056
Wan C, et al. Antioxidant and Α-glucosidase Inhibitory Phenolics Isolated From Highbush Blueberry Flowers. Food Chem. 2012 Dec 1;135(3):1929-37. PubMed PMID: 22953942.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant and α-glucosidase inhibitory phenolics isolated from highbush blueberry flowers. AU - Wan,Chunpeng, AU - Yuan,Tao, AU - Cirello,Amanda L, AU - Seeram,Navindra P, Y1 - 2012/07/04/ PY - 2012/02/22/received PY - 2012/05/15/revised PY - 2012/06/15/accepted PY - 2012/9/8/entrez PY - 2012/9/8/pubmed PY - 2013/2/7/medline SP - 1929 EP - 37 JF - Food chemistry JO - Food Chem VL - 135 IS - 3 N2 - Blueberries have been extensively researched, but there are limited studies on other parts of the plant. Here we report the first phytochemical examination of highbush blueberry (Vaccinium corymbosum) flowers, which yielded 21 phenolics. The compounds were identified from extensive NMR and mass spectral analyses and included five caffeic acid (1-5), three coumaric acid (6-8), and two cinnamyl alcohol (9-10) derivatives, eight flavonol glycosides (11-18), and three phenylpropanoid-substituted catechins (19-21). The isolates were evaluated for antioxidant and α-glucosidase inhibitory activities. Overall, the flavonol glycosides and phenylpropanoid-substituted catechins showed superior antioxidant activities compared to the positive controls, vitamin C (IC(50)=63μM) and butylated hydroxytoluene (IC(50)=1548μM). Similarly, these phenolic sub-classes were more potent α-glucosidase inhibitors than the clinical drug, acarbose (IC(50)=200μM). Thus, non-consumed parts of food plants may be exploited as sources of bioactive compounds beyond their edible parts alone for nutraceutical and functional food applications. SN - 1873-7072 UR - https://www.unboundmedicine.com/medline/citation/22953942/Antioxidant_and_α_glucosidase_inhibitory_phenolics_isolated_from_highbush_blueberry_flowers_ DB - PRIME DP - Unbound Medicine ER -