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Antiulcer activity of the chloroform extract of Bauhinia purpurea leaf.
Pharm Biol. 2012 Dec; 50(12):1498-507.PB

Abstract

CONTEXT

Bauhinia purpurea L. (Fabaceae) is a native plant species of many Asian countries, including Malaysia and India. In India, the root, stem, bark, and leaf of B. purpurea are used to treat various ailments, including ulcers and stomach cancer.

OBJECTIVE

In an attempt to establish its pharmacological potential, we studied the antiulcer activity of lipid-soluble extract of B. purpurea obtained via extraction of air-dried leaves using chloroform.

MATERIALS AND METHODS

The rats were administered the chloroform extract (dose range of 100-1000 mg/kg) orally after 24 h fasting. They were subjected to the absolute ethanol- and indomethacin-induced gastric ulcer, and pyloric ligation assays after 30 min. The acute toxicity study was conducted using a single oral dose of 5000 mg/kg extract and the rats were observed for the period of 14 days. omeprazole (30 mg/kg) was used as the standard control.

RESULTS

At 5000 mg/kg, the extract produced no sign of toxicity in rats. The extract exhibited significant (p < 0.05) dose-dependent antiulcer activity for the ethanol-induced model. The extract also significantly (p < 0.05) increased the gastric wall mucus production and pH of gastric content, while significantly (p < 0.05) reducing the total volume and total acidity of the gastric content in the pylorus ligation assay.

DISCUSSION AND CONCLUSION

The extract possesses antiulcer, antisecretory and cytoprotective activities, which could be attributed to its flavonoid and tannin content. These findings provide new information regarding the potential of lipid-soluble compounds of B. purpurea for the prevention and treatment of gastric ulcers.

Authors+Show Affiliations

Faculty of Pharmacy, Universiti Teknologi MARA , Puncak Alam Campus, Bandar Puncak Alam, Selangor, Malaysia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22954284

Citation

Hisam, Elly Ezlinda Abdul, et al. "Antiulcer Activity of the Chloroform Extract of Bauhinia Purpurea Leaf." Pharmaceutical Biology, vol. 50, no. 12, 2012, pp. 1498-507.
Hisam EE, Zakaria ZA, Mohtaruddin N, et al. Antiulcer activity of the chloroform extract of Bauhinia purpurea leaf. Pharm Biol. 2012;50(12):1498-507.
Hisam, E. E., Zakaria, Z. A., Mohtaruddin, N., Rofiee, M. S., Hamid, H. A., & Othman, F. (2012). Antiulcer activity of the chloroform extract of Bauhinia purpurea leaf. Pharmaceutical Biology, 50(12), 1498-507. https://doi.org/10.3109/13880209.2012.685945
Hisam EE, et al. Antiulcer Activity of the Chloroform Extract of Bauhinia Purpurea Leaf. Pharm Biol. 2012;50(12):1498-507. PubMed PMID: 22954284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiulcer activity of the chloroform extract of Bauhinia purpurea leaf. AU - Hisam,Elly Ezlinda Abdul, AU - Zakaria,Zainul Amiruddin, AU - Mohtaruddin,Norhafizah, AU - Rofiee,Mohd Salleh, AU - Hamid,Hasiah Ab, AU - Othman,Fezah, Y1 - 2012/09/11/ PY - 2012/9/8/entrez PY - 2012/9/8/pubmed PY - 2013/4/30/medline SP - 1498 EP - 507 JF - Pharmaceutical biology JO - Pharm Biol VL - 50 IS - 12 N2 - CONTEXT: Bauhinia purpurea L. (Fabaceae) is a native plant species of many Asian countries, including Malaysia and India. In India, the root, stem, bark, and leaf of B. purpurea are used to treat various ailments, including ulcers and stomach cancer. OBJECTIVE: In an attempt to establish its pharmacological potential, we studied the antiulcer activity of lipid-soluble extract of B. purpurea obtained via extraction of air-dried leaves using chloroform. MATERIALS AND METHODS: The rats were administered the chloroform extract (dose range of 100-1000 mg/kg) orally after 24 h fasting. They were subjected to the absolute ethanol- and indomethacin-induced gastric ulcer, and pyloric ligation assays after 30 min. The acute toxicity study was conducted using a single oral dose of 5000 mg/kg extract and the rats were observed for the period of 14 days. omeprazole (30 mg/kg) was used as the standard control. RESULTS: At 5000 mg/kg, the extract produced no sign of toxicity in rats. The extract exhibited significant (p < 0.05) dose-dependent antiulcer activity for the ethanol-induced model. The extract also significantly (p < 0.05) increased the gastric wall mucus production and pH of gastric content, while significantly (p < 0.05) reducing the total volume and total acidity of the gastric content in the pylorus ligation assay. DISCUSSION AND CONCLUSION: The extract possesses antiulcer, antisecretory and cytoprotective activities, which could be attributed to its flavonoid and tannin content. These findings provide new information regarding the potential of lipid-soluble compounds of B. purpurea for the prevention and treatment of gastric ulcers. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/22954284/Antiulcer_activity_of_the_chloroform_extract_of_Bauhinia_purpurea_leaf_ L2 - https://www.tandfonline.com/doi/full/10.3109/13880209.2012.685945 DB - PRIME DP - Unbound Medicine ER -