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PRO: osmotherapy for the treatment of acute intracranial hypertension.
J Neurosurg Anesthesiol. 2012 Oct; 24(4):402-6.JN

Abstract

Persisting severe brain edema causes intracranial hypertension and is associated with poor patient outcome. The treatment of acute intracranial hypertension is complex and multimodal. The most important options for medical treatment include controlled ventilation and osmotherapy, maintenance of brain and body homeostasis, and sedation. Osmotherapy is recommended in all relevant guidelines. The 2 osmotic agents most frequently used are mannitol and hypertonic saline. Both reduce intracranial pressure and improve cerebral perfusion and cerebral oxygen delivery. However, hypertonic saline seems advantageous over mannitol in many situations. In multitrauma patients, hypertonic saline contributes to hemodynamic stabilization and to the prevention of secondary insults. In addition, hypertonic saline has neurohumoral and immunologic effects, which may be beneficial in cerebral resuscitation.

Authors+Show Affiliations

Département d’Anesthésiologie et de Réanimation, Hôpital de Sion, Suisse, Switzerland.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22955194

Citation

Grape, Sina, and Patrick Ravussin. "PRO: Osmotherapy for the Treatment of Acute Intracranial Hypertension." Journal of Neurosurgical Anesthesiology, vol. 24, no. 4, 2012, pp. 402-6.
Grape S, Ravussin P. PRO: osmotherapy for the treatment of acute intracranial hypertension. J Neurosurg Anesthesiol. 2012;24(4):402-6.
Grape, S., & Ravussin, P. (2012). PRO: osmotherapy for the treatment of acute intracranial hypertension. Journal of Neurosurgical Anesthesiology, 24(4), 402-6. https://doi.org/10.1097/01.ana.0000419729.52363.64
Grape S, Ravussin P. PRO: Osmotherapy for the Treatment of Acute Intracranial Hypertension. J Neurosurg Anesthesiol. 2012;24(4):402-6. PubMed PMID: 22955194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PRO: osmotherapy for the treatment of acute intracranial hypertension. AU - Grape,Sina, AU - Ravussin,Patrick, PY - 2012/9/8/entrez PY - 2012/9/8/pubmed PY - 2013/1/30/medline SP - 402 EP - 6 JF - Journal of neurosurgical anesthesiology JO - J Neurosurg Anesthesiol VL - 24 IS - 4 N2 - Persisting severe brain edema causes intracranial hypertension and is associated with poor patient outcome. The treatment of acute intracranial hypertension is complex and multimodal. The most important options for medical treatment include controlled ventilation and osmotherapy, maintenance of brain and body homeostasis, and sedation. Osmotherapy is recommended in all relevant guidelines. The 2 osmotic agents most frequently used are mannitol and hypertonic saline. Both reduce intracranial pressure and improve cerebral perfusion and cerebral oxygen delivery. However, hypertonic saline seems advantageous over mannitol in many situations. In multitrauma patients, hypertonic saline contributes to hemodynamic stabilization and to the prevention of secondary insults. In addition, hypertonic saline has neurohumoral and immunologic effects, which may be beneficial in cerebral resuscitation. SN - 1537-1921 UR - https://www.unboundmedicine.com/medline/citation/22955194/PRO:_osmotherapy_for_the_treatment_of_acute_intracranial_hypertension_ L2 - http://dx.doi.org/10.1097/01.ana.0000419729.52363.64 DB - PRIME DP - Unbound Medicine ER -