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Proteomic biomarkers for ovarian cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration.
Fertil Steril 2012; 98(6):1590-601.e1FS

Abstract

OBJECTIVE

To review and identify possible biomarkers for ovarian cancer (OC) in women with polycystic ovary syndrome (PCOS).

DESIGN

Systematic literature searches of MEDLINE, EMBASE, and Cochrane using the search terms "proteomics," "proteomic," and "ovarian cancer" or "ovarian carcinoma." Proteomic biomarkers for OC were then integrated with an updated previously published database of all proteomic biomarkers identified to date in patients with PCOS.

SETTING

Academic department of obstetrics and gynecology in the United Kingdom.

PATIENT(S)

A total of 180 women identified in the six studies.

INTERVENTION(S)

Tissue samples from women with OC vs. tissue samples from women without OC.

MAIN OUTCOME MEASURE(S)

Proteomic biomarkers, proteomic technique used, and methodologic quality score.

RESULT(S)

A panel of six biomarkers was overexpressed both in women with OC and in women with PCOS. These biomarkers include calreticulin, fibrinogen-γ, superoxide dismutase, vimentin, malate dehydrogenase, and lamin B2.

CONCLUSION(S)

These biomarkers could help improve our understanding of the links between PCOS and OC and could potentially be used to identify subgroups of women with PCOS at increased risk of OC. More studies are required to further evaluate the role these biomarkers play in women with PCOS and OC.

Authors+Show Affiliations

Division of Human Development, School of Clinical Sciences, University of Nottingham, Queen's Medical Centre Campus, Nottingham University Hospitals, Nottingham, United Kingdom. ngalazis@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

22959458

Citation

Galazis, Nicolas, et al. "Proteomic Biomarkers for Ovarian Cancer Risk in Women With Polycystic Ovary Syndrome: a Systematic Review and Biomarker Database Integration." Fertility and Sterility, vol. 98, no. 6, 2012, pp. 1590-601.e1.
Galazis N, Olaleye O, Haoula Z, et al. Proteomic biomarkers for ovarian cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration. Fertil Steril. 2012;98(6):1590-601.e1.
Galazis, N., Olaleye, O., Haoula, Z., Layfield, R., & Atiomo, W. (2012). Proteomic biomarkers for ovarian cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration. Fertility and Sterility, 98(6), pp. 1590-601.e1. doi:10.1016/j.fertnstert.2012.08.002.
Galazis N, et al. Proteomic Biomarkers for Ovarian Cancer Risk in Women With Polycystic Ovary Syndrome: a Systematic Review and Biomarker Database Integration. Fertil Steril. 2012;98(6):1590-601.e1. PubMed PMID: 22959458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Proteomic biomarkers for ovarian cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration. AU - Galazis,Nicolas, AU - Olaleye,Olalekan, AU - Haoula,Zeina, AU - Layfield,Robert, AU - Atiomo,William, Y1 - 2012/09/06/ PY - 2012/02/14/received PY - 2012/08/06/revised PY - 2012/08/06/accepted PY - 2012/9/11/entrez PY - 2012/9/11/pubmed PY - 2013/2/6/medline SP - 1590 EP - 601.e1 JF - Fertility and sterility JO - Fertil. Steril. VL - 98 IS - 6 N2 - OBJECTIVE: To review and identify possible biomarkers for ovarian cancer (OC) in women with polycystic ovary syndrome (PCOS). DESIGN: Systematic literature searches of MEDLINE, EMBASE, and Cochrane using the search terms "proteomics," "proteomic," and "ovarian cancer" or "ovarian carcinoma." Proteomic biomarkers for OC were then integrated with an updated previously published database of all proteomic biomarkers identified to date in patients with PCOS. SETTING: Academic department of obstetrics and gynecology in the United Kingdom. PATIENT(S): A total of 180 women identified in the six studies. INTERVENTION(S): Tissue samples from women with OC vs. tissue samples from women without OC. MAIN OUTCOME MEASURE(S): Proteomic biomarkers, proteomic technique used, and methodologic quality score. RESULT(S): A panel of six biomarkers was overexpressed both in women with OC and in women with PCOS. These biomarkers include calreticulin, fibrinogen-γ, superoxide dismutase, vimentin, malate dehydrogenase, and lamin B2. CONCLUSION(S): These biomarkers could help improve our understanding of the links between PCOS and OC and could potentially be used to identify subgroups of women with PCOS at increased risk of OC. More studies are required to further evaluate the role these biomarkers play in women with PCOS and OC. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/22959458/Proteomic_biomarkers_for_ovarian_cancer_risk_in_women_with_polycystic_ovary_syndrome:_a_systematic_review_and_biomarker_database_integration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(12)02054-7 DB - PRIME DP - Unbound Medicine ER -