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Otoferlin: a multi-C2 domain protein essential for hearing.
Trends Neurosci 2012; 35(11):671-80TN

Abstract

Sound is encoded at synapses between cochlear inner hair cells and the auditory nerve. These synapses are anatomically and functionally specialized to transmit acoustic information with high fidelity over a lifetime. The molecular mechanisms of hair-cell transmitter release have recently attracted substantial interest. Here we review progress toward understanding otoferlin, a multi-C2 domain protein identified a decade ago by genetic analysis of human deafness. Otoferlin functions in hair-cell exocytosis. Several otoferlin C2 domains bind to Ca2+, phospholipids, and proteins. Current research reveals requirements for otoferlin in priming and fusion of synaptic vesicles during sound encoding. Understanding the molecular mechanisms through which otoferlin functions also has important implications for understanding the disease mechanisms that lead to deafness.

Authors+Show Affiliations

InnerEarLab, Department of Otolaryngology and Collaborative Research Center 889, University Medical Center Göttingen, Göttingen, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22959777

Citation

Pangršič, Tina, et al. "Otoferlin: a multi-C2 Domain Protein Essential for Hearing." Trends in Neurosciences, vol. 35, no. 11, 2012, pp. 671-80.
Pangršič T, Reisinger E, Moser T. Otoferlin: a multi-C2 domain protein essential for hearing. Trends Neurosci. 2012;35(11):671-80.
Pangršič, T., Reisinger, E., & Moser, T. (2012). Otoferlin: a multi-C2 domain protein essential for hearing. Trends in Neurosciences, 35(11), pp. 671-80. doi:10.1016/j.tins.2012.08.002.
Pangršič T, Reisinger E, Moser T. Otoferlin: a multi-C2 Domain Protein Essential for Hearing. Trends Neurosci. 2012;35(11):671-80. PubMed PMID: 22959777.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Otoferlin: a multi-C2 domain protein essential for hearing. AU - Pangršič,Tina, AU - Reisinger,Ellen, AU - Moser,Tobias, Y1 - 2012/09/07/ PY - 2012/05/17/received PY - 2012/07/25/revised PY - 2012/08/13/accepted PY - 2012/9/11/entrez PY - 2012/9/11/pubmed PY - 2013/4/6/medline SP - 671 EP - 80 JF - Trends in neurosciences JO - Trends Neurosci. VL - 35 IS - 11 N2 - Sound is encoded at synapses between cochlear inner hair cells and the auditory nerve. These synapses are anatomically and functionally specialized to transmit acoustic information with high fidelity over a lifetime. The molecular mechanisms of hair-cell transmitter release have recently attracted substantial interest. Here we review progress toward understanding otoferlin, a multi-C2 domain protein identified a decade ago by genetic analysis of human deafness. Otoferlin functions in hair-cell exocytosis. Several otoferlin C2 domains bind to Ca2+, phospholipids, and proteins. Current research reveals requirements for otoferlin in priming and fusion of synaptic vesicles during sound encoding. Understanding the molecular mechanisms through which otoferlin functions also has important implications for understanding the disease mechanisms that lead to deafness. SN - 1878-108X UR - https://www.unboundmedicine.com/medline/citation/22959777/Otoferlin:_a_multi_C2_domain_protein_essential_for_hearing_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-2236(12)00150-6 DB - PRIME DP - Unbound Medicine ER -