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Short-term molecular-level effects of silver nanoparticle exposure on the earthworm, Eisenia fetida.
Environ Pollut. 2012 Dec; 171:249-55.EP

Abstract

Short-term changes in levels of expression of nine stress response genes and oxidative damage of proteins were examined in Eisenia fetida exposed to polyvinylpyrrolidone (PVP) coated Ag nanoparticles (Ag-NP) and AgNO(3) in natural soils. The responses varied significantly among days with the highest number of significant changes occurring on day three. Similarity in gene expression patterns between Ag-NPs and AgNO(3) and significant relationships of expression of CAT and HSP70 with Ag soil concentration suggest similarity in toxicity mechanisms of Ag ions and NPs. Significant increases in the levels of protein carbonyls on day three of the exposure to both ions and Ag-NPs indicate that both treatments induced oxidative stress. Our results suggest that Ag ions drive short term toxicity of Ag-NPs in E. fetida. However, given that <15% of Ag in the NPs was oxidized in these soils, dissolution of Ag-NPs is likely to occur after or during their uptake.

Authors+Show Affiliations

Department of Plant and Soil Sciences, University of Kentucky, Lexington, KY 40546, USA. olga.tsyusko@uky.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

22960366

Citation

Tsyusko, Olga V., et al. "Short-term Molecular-level Effects of Silver Nanoparticle Exposure On the Earthworm, Eisenia Fetida." Environmental Pollution (Barking, Essex : 1987), vol. 171, 2012, pp. 249-55.
Tsyusko OV, Hardas SS, Shoults-Wilson WA, et al. Short-term molecular-level effects of silver nanoparticle exposure on the earthworm, Eisenia fetida. Environ Pollut. 2012;171:249-55.
Tsyusko, O. V., Hardas, S. S., Shoults-Wilson, W. A., Starnes, C. P., Joice, G., Butterfield, D. A., & Unrine, J. M. (2012). Short-term molecular-level effects of silver nanoparticle exposure on the earthworm, Eisenia fetida. Environmental Pollution (Barking, Essex : 1987), 171, 249-55. https://doi.org/10.1016/j.envpol.2012.08.003
Tsyusko OV, et al. Short-term Molecular-level Effects of Silver Nanoparticle Exposure On the Earthworm, Eisenia Fetida. Environ Pollut. 2012;171:249-55. PubMed PMID: 22960366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-term molecular-level effects of silver nanoparticle exposure on the earthworm, Eisenia fetida. AU - Tsyusko,Olga V, AU - Hardas,Sarita S, AU - Shoults-Wilson,W Aaron, AU - Starnes,Catherine P, AU - Joice,Greg, AU - Butterfield,D Allan, AU - Unrine,Jason M, Y1 - 2012/09/05/ PY - 2012/05/16/received PY - 2012/08/03/revised PY - 2012/08/07/accepted PY - 2012/9/11/entrez PY - 2012/9/11/pubmed PY - 2012/12/10/medline SP - 249 EP - 55 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ Pollut VL - 171 N2 - Short-term changes in levels of expression of nine stress response genes and oxidative damage of proteins were examined in Eisenia fetida exposed to polyvinylpyrrolidone (PVP) coated Ag nanoparticles (Ag-NP) and AgNO(3) in natural soils. The responses varied significantly among days with the highest number of significant changes occurring on day three. Similarity in gene expression patterns between Ag-NPs and AgNO(3) and significant relationships of expression of CAT and HSP70 with Ag soil concentration suggest similarity in toxicity mechanisms of Ag ions and NPs. Significant increases in the levels of protein carbonyls on day three of the exposure to both ions and Ag-NPs indicate that both treatments induced oxidative stress. Our results suggest that Ag ions drive short term toxicity of Ag-NPs in E. fetida. However, given that <15% of Ag in the NPs was oxidized in these soils, dissolution of Ag-NPs is likely to occur after or during their uptake. SN - 1873-6424 UR - https://www.unboundmedicine.com/medline/citation/22960366/Short_term_molecular_level_effects_of_silver_nanoparticle_exposure_on_the_earthworm_Eisenia_fetida_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0269-7491(12)00387-9 DB - PRIME DP - Unbound Medicine ER -