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Twin screw granulation: steps in granule growth.
Int J Pharm. 2012 Nov 15; 438(1-2):20-32.IJ

Abstract

The present work focuses on the study of the progression of granules in different compartments along the length of screws in a twin screw granulator (TSG). The effects of varying powder feed rate; liquid to solid ratio and viscosity of granulation liquid on properties of granules was studied. The bigger granules produced at the start of the process were found to change in terms of size, shape and strength along the screw length at all the conditions investigated. The granules became more spherical and their strength increased along the screw length. Tracer granules were also introduced in order to understand the role of kneading and conveying elements in the TSG. The kneading elements promoted consolidation and breakage while the conveying elements led to coalescence, breakage and some consolidation. The results presented here help to provide a qualitative and quantitative understanding of the twin screw granulation process.

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Authors+Show Affiliations

Dhenge RM
Department of Chemical and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK.
Cartwright JJ
No affiliation info available
Hounslow MJ
No affiliation info available
Salman AD
No affiliation info available

MeSH

CelluloseExcipientsPowdersTechnology, PharmaceuticalWater

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22960611

Citation

Dhenge, Ranjit M., et al. "Twin Screw Granulation: Steps in Granule Growth." International Journal of Pharmaceutics, vol. 438, no. 1-2, 2012, pp. 20-32.
Dhenge RM, Cartwright JJ, Hounslow MJ, et al. Twin screw granulation: steps in granule growth. Int J Pharm. 2012;438(1-2):20-32.
Dhenge, R. M., Cartwright, J. J., Hounslow, M. J., & Salman, A. D. (2012). Twin screw granulation: steps in granule growth. International Journal of Pharmaceutics, 438(1-2), 20-32. https://doi.org/10.1016/j.ijpharm.2012.08.049
Dhenge RM, et al. Twin Screw Granulation: Steps in Granule Growth. Int J Pharm. 2012 Nov 15;438(1-2):20-32. PubMed PMID: 22960611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Twin screw granulation: steps in granule growth. AU - Dhenge,Ranjit M, AU - Cartwright,James J, AU - Hounslow,Michael J, AU - Salman,Agba D, Y1 - 2012/09/05/ PY - 2012/07/09/received PY - 2012/08/27/accepted PY - 2012/9/11/entrez PY - 2012/9/11/pubmed PY - 2013/3/21/medline SP - 20 EP - 32 JF - International journal of pharmaceutics JO - Int J Pharm VL - 438 IS - 1-2 N2 - The present work focuses on the study of the progression of granules in different compartments along the length of screws in a twin screw granulator (TSG). The effects of varying powder feed rate; liquid to solid ratio and viscosity of granulation liquid on properties of granules was studied. The bigger granules produced at the start of the process were found to change in terms of size, shape and strength along the screw length at all the conditions investigated. The granules became more spherical and their strength increased along the screw length. Tracer granules were also introduced in order to understand the role of kneading and conveying elements in the TSG. The kneading elements promoted consolidation and breakage while the conveying elements led to coalescence, breakage and some consolidation. The results presented here help to provide a qualitative and quantitative understanding of the twin screw granulation process. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/22960611/Twin_screw_granulation:_steps_in_granule_growth_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(12)00857-5 DB - PRIME DP - Unbound Medicine ER -