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Pre-diagnostic alcohol consumption and postmenopausal breast cancer survival: a prospective patient cohort study.
Breast Cancer Res Treat 2012; 136(1):195-207BC

Abstract

Study results on the association of alcohol consumption with breast cancer survival are inconsistent, partly due to the use of different survival outcomes. We assessed the association of pre-diagnostic alcohol consumption with survival and recurrence in a prospective cohort study in Germany including 2,522 postmenopausal breast cancer patients aged 50-74 years. Patients were diagnosed between 2001 and 2005 and vital status, causes of death, and recurrences were verified through the end of 2009. Cox proportional hazards models were stratified by age at diagnosis and study center and adjusted for relevant prognostic factors. Alcohol consumption was non-linearly associated with increased breast cancer-specific mortality [e.g., ≥12 vs. <0.5 g/day: hazard ratio (HR) = 1.74, 95 % confidence interval (CI): 1.13, 2.67]. Results were independent of estrogen receptor status. A non-significantly decreased risk of mortality due to other causes was found (≥12 vs. <0.5 g/day: HR = 0.67, 95 % CI: 0.35, 1.29). Alcohol consumption was not associated with overall mortality (≥12 vs. <0.5 g/day: HR = 1.28, 95 % CI: 0.90, 1.81) and breast cancer recurrence (≥12 vs. <0.5 g/day: HR = 1.08, 95 % CI: 0.73, 1.58). In conclusion, our findings show that consumption of alcohol before diagnosis is non-linearly associated with increased breast cancer-specific mortality but may be associated with decreased risk of mortality due to other causes.

Authors+Show Affiliations

Division of Cancer Epidemiology, Unit of Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. a.vrieling@dkfz-heidelberg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22961011

Citation

Vrieling, Alina, et al. "Pre-diagnostic Alcohol Consumption and Postmenopausal Breast Cancer Survival: a Prospective Patient Cohort Study." Breast Cancer Research and Treatment, vol. 136, no. 1, 2012, pp. 195-207.
Vrieling A, Buck K, Heinz J, et al. Pre-diagnostic alcohol consumption and postmenopausal breast cancer survival: a prospective patient cohort study. Breast Cancer Res Treat. 2012;136(1):195-207.
Vrieling, A., Buck, K., Heinz, J., Obi, N., Benner, A., Flesch-Janys, D., & Chang-Claude, J. (2012). Pre-diagnostic alcohol consumption and postmenopausal breast cancer survival: a prospective patient cohort study. Breast Cancer Research and Treatment, 136(1), pp. 195-207. doi:10.1007/s10549-012-2230-2.
Vrieling A, et al. Pre-diagnostic Alcohol Consumption and Postmenopausal Breast Cancer Survival: a Prospective Patient Cohort Study. Breast Cancer Res Treat. 2012;136(1):195-207. PubMed PMID: 22961011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pre-diagnostic alcohol consumption and postmenopausal breast cancer survival: a prospective patient cohort study. AU - Vrieling,Alina, AU - Buck,Katharina, AU - Heinz,Judith, AU - Obi,Nadia, AU - Benner,Axel, AU - Flesch-Janys,Dieter, AU - Chang-Claude,Jenny, Y1 - 2012/09/11/ PY - 2012/07/03/received PY - 2012/08/21/accepted PY - 2012/9/11/entrez PY - 2012/9/11/pubmed PY - 2013/5/25/medline SP - 195 EP - 207 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 136 IS - 1 N2 - Study results on the association of alcohol consumption with breast cancer survival are inconsistent, partly due to the use of different survival outcomes. We assessed the association of pre-diagnostic alcohol consumption with survival and recurrence in a prospective cohort study in Germany including 2,522 postmenopausal breast cancer patients aged 50-74 years. Patients were diagnosed between 2001 and 2005 and vital status, causes of death, and recurrences were verified through the end of 2009. Cox proportional hazards models were stratified by age at diagnosis and study center and adjusted for relevant prognostic factors. Alcohol consumption was non-linearly associated with increased breast cancer-specific mortality [e.g., ≥12 vs. <0.5 g/day: hazard ratio (HR) = 1.74, 95 % confidence interval (CI): 1.13, 2.67]. Results were independent of estrogen receptor status. A non-significantly decreased risk of mortality due to other causes was found (≥12 vs. <0.5 g/day: HR = 0.67, 95 % CI: 0.35, 1.29). Alcohol consumption was not associated with overall mortality (≥12 vs. <0.5 g/day: HR = 1.28, 95 % CI: 0.90, 1.81) and breast cancer recurrence (≥12 vs. <0.5 g/day: HR = 1.08, 95 % CI: 0.73, 1.58). In conclusion, our findings show that consumption of alcohol before diagnosis is non-linearly associated with increased breast cancer-specific mortality but may be associated with decreased risk of mortality due to other causes. SN - 1573-7217 UR - https://www.unboundmedicine.com/medline/citation/22961011/Pre_diagnostic_alcohol_consumption_and_postmenopausal_breast_cancer_survival:_a_prospective_patient_cohort_study_ L2 - https://doi.org/10.1007/s10549-012-2230-2 DB - PRIME DP - Unbound Medicine ER -