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Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline.
J Clin Endocrinol Metab. 2012 Sep; 97(9):2969-89.JC

Abstract

OBJECTIVE

The aim was to develop clinical practice guidelines on hypertriglyceridemia.

PARTICIPANTS

The Task Force included a chair selected by The Endocrine Society Clinical Guidelines Subcommittee (CGS), five additional experts in the field, and a methodologist. The authors received no corporate funding or remuneration.

CONSENSUS PROCESS

Consensus was guided by systematic reviews of evidence, e-mail discussion, conference calls, and one in-person meeting. The guidelines were reviewed and approved sequentially by The Endocrine Society's CGS and Clinical Affairs Core Committee, members responding to a web posting, and The Endocrine Society Council. At each stage, the Task Force incorporated changes in response to written comments.

CONCLUSIONS

The Task Force recommends that the diagnosis of hypertriglyceridemia be based on fasting levels, that mild and moderate hypertriglyceridemia (triglycerides of 150-999 mg/dl) be diagnosed to aid in the evaluation of cardiovascular risk, and that severe and very severe hypertriglyceridemia (triglycerides of > 1000 mg/dl) be considered a risk for pancreatitis. The Task Force also recommends that patients with hypertriglyceridemia be evaluated for secondary causes of hyperlipidemia and that subjects with primary hypertriglyceridemia be evaluated for family history of dyslipidemia and cardiovascular disease. The Task Force recommends that the treatment goal in patients with moderate hypertriglyceridemia be a non-high-density lipoprotein cholesterol level in agreement with National Cholesterol Education Program Adult Treatment Panel guidelines. The initial treatment should be lifestyle therapy; a combination of diet modification and drug therapy may also be considered. In patients with severe or very severe hypertriglyceridemia, a fibrate should be used as a first-line agent.

Authors+Show Affiliations

University of California, Davis, Sacramento, California 95817, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Practice Guideline
Review

Language

eng

PubMed ID

22962670

Citation

Berglund, Lars, et al. "Evaluation and Treatment of Hypertriglyceridemia: an Endocrine Society Clinical Practice Guideline." The Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 9, 2012, pp. 2969-89.
Berglund L, Brunzell JD, Goldberg AC, et al. Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2012;97(9):2969-89.
Berglund, L., Brunzell, J. D., Goldberg, A. C., Goldberg, I. J., Sacks, F., Murad, M. H., & Stalenhoef, A. F. (2012). Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology and Metabolism, 97(9), 2969-89. https://doi.org/10.1210/jc.2011-3213
Berglund L, et al. Evaluation and Treatment of Hypertriglyceridemia: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2012;97(9):2969-89. PubMed PMID: 22962670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline. AU - Berglund,Lars, AU - Brunzell,John D, AU - Goldberg,Anne C, AU - Goldberg,Ira J, AU - Sacks,Frank, AU - Murad,Mohammad Hassan, AU - Stalenhoef,Anton F H, AU - ,, PY - 2012/9/11/entrez PY - 2012/9/11/pubmed PY - 2012/12/10/medline SP - 2969 EP - 89 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 97 IS - 9 N2 - OBJECTIVE: The aim was to develop clinical practice guidelines on hypertriglyceridemia. PARTICIPANTS: The Task Force included a chair selected by The Endocrine Society Clinical Guidelines Subcommittee (CGS), five additional experts in the field, and a methodologist. The authors received no corporate funding or remuneration. CONSENSUS PROCESS: Consensus was guided by systematic reviews of evidence, e-mail discussion, conference calls, and one in-person meeting. The guidelines were reviewed and approved sequentially by The Endocrine Society's CGS and Clinical Affairs Core Committee, members responding to a web posting, and The Endocrine Society Council. At each stage, the Task Force incorporated changes in response to written comments. CONCLUSIONS: The Task Force recommends that the diagnosis of hypertriglyceridemia be based on fasting levels, that mild and moderate hypertriglyceridemia (triglycerides of 150-999 mg/dl) be diagnosed to aid in the evaluation of cardiovascular risk, and that severe and very severe hypertriglyceridemia (triglycerides of > 1000 mg/dl) be considered a risk for pancreatitis. The Task Force also recommends that patients with hypertriglyceridemia be evaluated for secondary causes of hyperlipidemia and that subjects with primary hypertriglyceridemia be evaluated for family history of dyslipidemia and cardiovascular disease. The Task Force recommends that the treatment goal in patients with moderate hypertriglyceridemia be a non-high-density lipoprotein cholesterol level in agreement with National Cholesterol Education Program Adult Treatment Panel guidelines. The initial treatment should be lifestyle therapy; a combination of diet modification and drug therapy may also be considered. In patients with severe or very severe hypertriglyceridemia, a fibrate should be used as a first-line agent. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/22962670/Evaluation_and_treatment_of_hypertriglyceridemia:_an_Endocrine_Society_clinical_practice_guideline_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2011-3213 DB - PRIME DP - Unbound Medicine ER -