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Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration.
Toxicol Lett. 2012 Nov 15; 214(3):314-9.TL

Abstract

Cannabidiol (CBD), a major non-psychotropic constituent of fiber-type cannabis plant, has been reported to possess diverse biological activities, including anti-proliferative effect on cancer cells. Although CBD is obtained from non-enzymatic decarboxylation of its parent molecule, cannabidiolic acid (CBDA), few studies have investigated whether CBDA itself is biologically active. Results of the current investigation revealed that CBDA inhibits migration of the highly invasive MDA-MB-231 human breast cancer cells, apparently through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase, RhoA. It is established that activation of the RhoA signaling pathway leads to inhibition of the mobility of various cancer cells, including MDA-MB-231 cells. The data presented in this report suggest for the first time that as an active component in the cannabis plant, CBDA offers potential therapeutic modality in the abrogation of cancer cell migration, including aggressive breast cancers.

Authors+Show Affiliations

Department of Molecular Biology, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-8511, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

22963825

Citation

Takeda, Shuso, et al. "Cannabidiolic Acid, a Major Cannabinoid in Fiber-type Cannabis, Is an Inhibitor of MDA-MB-231 Breast Cancer Cell Migration." Toxicology Letters, vol. 214, no. 3, 2012, pp. 314-9.
Takeda S, Okajima S, Miyoshi H, et al. Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration. Toxicol Lett. 2012;214(3):314-9.
Takeda, S., Okajima, S., Miyoshi, H., Yoshida, K., Okamoto, Y., Okada, T., Amamoto, T., Watanabe, K., Omiecinski, C. J., & Aramaki, H. (2012). Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration. Toxicology Letters, 214(3), 314-9. https://doi.org/10.1016/j.toxlet.2012.08.029
Takeda S, et al. Cannabidiolic Acid, a Major Cannabinoid in Fiber-type Cannabis, Is an Inhibitor of MDA-MB-231 Breast Cancer Cell Migration. Toxicol Lett. 2012 Nov 15;214(3):314-9. PubMed PMID: 22963825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration. AU - Takeda,Shuso, AU - Okajima,Shunsuke, AU - Miyoshi,Hiroko, AU - Yoshida,Kazutaka, AU - Okamoto,Yoshiko, AU - Okada,Tomoko, AU - Amamoto,Toshiaki, AU - Watanabe,Kazuhito, AU - Omiecinski,Curtis J, AU - Aramaki,Hironori, Y1 - 2012/09/08/ PY - 2012/06/19/received PY - 2012/08/31/revised PY - 2012/08/31/accepted PY - 2012/9/12/entrez PY - 2012/9/12/pubmed PY - 2013/1/9/medline SP - 314 EP - 9 JF - Toxicology letters JO - Toxicol Lett VL - 214 IS - 3 N2 - Cannabidiol (CBD), a major non-psychotropic constituent of fiber-type cannabis plant, has been reported to possess diverse biological activities, including anti-proliferative effect on cancer cells. Although CBD is obtained from non-enzymatic decarboxylation of its parent molecule, cannabidiolic acid (CBDA), few studies have investigated whether CBDA itself is biologically active. Results of the current investigation revealed that CBDA inhibits migration of the highly invasive MDA-MB-231 human breast cancer cells, apparently through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase, RhoA. It is established that activation of the RhoA signaling pathway leads to inhibition of the mobility of various cancer cells, including MDA-MB-231 cells. The data presented in this report suggest for the first time that as an active component in the cannabis plant, CBDA offers potential therapeutic modality in the abrogation of cancer cell migration, including aggressive breast cancers. SN - 1879-3169 UR - https://www.unboundmedicine.com/medline/citation/22963825/Cannabidiolic_acid_a_major_cannabinoid_in_fiber_type_cannabis_is_an_inhibitor_of_MDA_MB_231_breast_cancer_cell_migration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-4274(12)01285-4 DB - PRIME DP - Unbound Medicine ER -