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Combination of tramadol with minocycline exerted synergistic effects on a rat model of nerve injury-induced neuropathic pain.
Neurosignals. 2013; 21(3-4):184-96.N

Abstract

Neuropathic pain is a refractory clinical problem. Certain drugs, such as tramadol, proved useful for the treatment of neuropathic pain by inhibiting the activity of nociceptive neurons. Moreover, studies indicated that suppression or modulation of glial activation could prevent or reverse neuropathic pain, for example with the microglia inhibitor minocycline. However, few present clinical therapeutics focused on both neuronal and glial participation when treating neuropathic pain. Therefore, the present study hypothesized that combination of tramadol with minocycline as neuronal and glial activation inhibitor may exert some synergistic effects on spinal nerve ligation (SNL)-induced neuropathic pain. Intrathecal tramadol or minocycline relieved SNL-induced mechanical allodynia in a dose-dependent manner. SNL-induced spinal dorsal horn Fos or OX42 expression was downregulated by intrathecal tramadol or minocycline. Combination of tramadol with minocycline exerted powerful and synergistic effects on SNL-induced neuropathic pain also in a dose-dependent manner. Moreover, the drug combination enhanced the suppression effects on SNL-induced spinal dorsal horn Fos and OX42 expression, compared to either drug administered alone. These results indicated that combination of tramadol with minocycline could exert synergistic effects on peripheral nerve injury-induced neuropathic pain; thus, a new strategy for treating neuropathic pain by breaking the interaction between neurons and glia bilaterally was also proposed.

Authors+Show Affiliations

Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi'an, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22964800

Citation

Mei, Xiao-Peng, et al. "Combination of Tramadol With Minocycline Exerted Synergistic Effects On a Rat Model of Nerve Injury-induced Neuropathic Pain." Neuro-Signals, vol. 21, no. 3-4, 2013, pp. 184-96.
Mei XP, Chen L, Wang W, et al. Combination of tramadol with minocycline exerted synergistic effects on a rat model of nerve injury-induced neuropathic pain. Neurosignals. 2013;21(3-4):184-96.
Mei, X. P., Chen, L., Wang, W., Wu, D., Wang, L. Y., Zhang, T., Zhang, H., Xu, L. X., & Li, Y. Q. (2013). Combination of tramadol with minocycline exerted synergistic effects on a rat model of nerve injury-induced neuropathic pain. Neuro-Signals, 21(3-4), 184-96. https://doi.org/10.1159/000338049
Mei XP, et al. Combination of Tramadol With Minocycline Exerted Synergistic Effects On a Rat Model of Nerve Injury-induced Neuropathic Pain. Neurosignals. 2013;21(3-4):184-96. PubMed PMID: 22964800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combination of tramadol with minocycline exerted synergistic effects on a rat model of nerve injury-induced neuropathic pain. AU - Mei,Xiao-Peng, AU - Chen,Lei, AU - Wang,Wei, AU - Wu,Dan, AU - Wang,Li-Ying, AU - Zhang,Ting, AU - Zhang,Hui, AU - Xu,Li-Xian, AU - Li,Yun-Qing, Y1 - 2012/09/07/ PY - 2011/12/12/received PY - 2012/02/29/accepted PY - 2012/9/12/entrez PY - 2012/9/12/pubmed PY - 2013/12/24/medline SP - 184 EP - 96 JF - Neuro-Signals JO - Neurosignals VL - 21 IS - 3-4 N2 - Neuropathic pain is a refractory clinical problem. Certain drugs, such as tramadol, proved useful for the treatment of neuropathic pain by inhibiting the activity of nociceptive neurons. Moreover, studies indicated that suppression or modulation of glial activation could prevent or reverse neuropathic pain, for example with the microglia inhibitor minocycline. However, few present clinical therapeutics focused on both neuronal and glial participation when treating neuropathic pain. Therefore, the present study hypothesized that combination of tramadol with minocycline as neuronal and glial activation inhibitor may exert some synergistic effects on spinal nerve ligation (SNL)-induced neuropathic pain. Intrathecal tramadol or minocycline relieved SNL-induced mechanical allodynia in a dose-dependent manner. SNL-induced spinal dorsal horn Fos or OX42 expression was downregulated by intrathecal tramadol or minocycline. Combination of tramadol with minocycline exerted powerful and synergistic effects on SNL-induced neuropathic pain also in a dose-dependent manner. Moreover, the drug combination enhanced the suppression effects on SNL-induced spinal dorsal horn Fos and OX42 expression, compared to either drug administered alone. These results indicated that combination of tramadol with minocycline could exert synergistic effects on peripheral nerve injury-induced neuropathic pain; thus, a new strategy for treating neuropathic pain by breaking the interaction between neurons and glia bilaterally was also proposed. SN - 1424-8638 UR - https://www.unboundmedicine.com/medline/citation/22964800/Combination_of_tramadol_with_minocycline_exerted_synergistic_effects_on_a_rat_model_of_nerve_injury_induced_neuropathic_pain_ L2 - https://www.karger.com?DOI=10.1159/000338049 DB - PRIME DP - Unbound Medicine ER -