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Impact of oral ubiquinol on blood oxidative stress and exercise performance.
Oxid Med Cell Longev. 2012; 2012:465020.OM

Abstract

Coenzyme Q10 (CoQ10) plays an important role in bioenergetic processes and has antioxidant activity. Fifteen exercise-trained individuals (10 men and 5 women; 30-65 years) received reduced CoQ10 (Kaneka QH ubiquinol; 300 mg per day) or a placebo for four weeks in a random order, double blind, cross-over design (3 week washout). After each four-week period, a graded exercise treadmill test and a repeated cycle sprint test were performed (separated by 48 hours). Blood samples were collected before and immediately following both exercise tests and analyzed for lactate, malondialdehyde, and hydrogen peroxide. Resting blood samples were analyzed for CoQ10 (ubiquinone and ubiquinol) profile before and after each treatment period. Treatment with CoQ10 resulted in a significant increase in total blood CoQ10 (138%; P = 0.02) and reduced blood CoQ10 (168%; P = 0.02), but did not improve exercise performance (with the exception of selected individuals) or impact oxidative stress. The relationship between the percentage change in total blood CoQ10 and the cycle sprint total work (R(2) = 0.6009) was noted to be moderate to strong. We conclude that treatment with CoQ10 in healthy, exercise-trained subjects increases total and reduced blood CoQ10, but this increase does not translate into improved exercise performance or decreased oxidative stress.

Authors+Show Affiliations

Cardiorespiratory-Metabolic Laboratory, The University of Memphis, Memphis, TN 38152, USA. rbloomer@memphis.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22966414

Citation

Bloomer, Richard J., et al. "Impact of Oral Ubiquinol On Blood Oxidative Stress and Exercise Performance." Oxidative Medicine and Cellular Longevity, vol. 2012, 2012, p. 465020.
Bloomer RJ, Canale RE, McCarthy CG, et al. Impact of oral ubiquinol on blood oxidative stress and exercise performance. Oxid Med Cell Longev. 2012;2012:465020.
Bloomer, R. J., Canale, R. E., McCarthy, C. G., & Farney, T. M. (2012). Impact of oral ubiquinol on blood oxidative stress and exercise performance. Oxidative Medicine and Cellular Longevity, 2012, 465020. https://doi.org/10.1155/2012/465020
Bloomer RJ, et al. Impact of Oral Ubiquinol On Blood Oxidative Stress and Exercise Performance. Oxid Med Cell Longev. 2012;2012:465020. PubMed PMID: 22966414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of oral ubiquinol on blood oxidative stress and exercise performance. AU - Bloomer,Richard J, AU - Canale,Robert E, AU - McCarthy,Cameron G, AU - Farney,Tyler M, Y1 - 2012/08/23/ PY - 2012/04/05/received PY - 2012/06/04/accepted PY - 2012/9/12/entrez PY - 2012/9/12/pubmed PY - 2013/1/17/medline SP - 465020 EP - 465020 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2012 N2 - Coenzyme Q10 (CoQ10) plays an important role in bioenergetic processes and has antioxidant activity. Fifteen exercise-trained individuals (10 men and 5 women; 30-65 years) received reduced CoQ10 (Kaneka QH ubiquinol; 300 mg per day) or a placebo for four weeks in a random order, double blind, cross-over design (3 week washout). After each four-week period, a graded exercise treadmill test and a repeated cycle sprint test were performed (separated by 48 hours). Blood samples were collected before and immediately following both exercise tests and analyzed for lactate, malondialdehyde, and hydrogen peroxide. Resting blood samples were analyzed for CoQ10 (ubiquinone and ubiquinol) profile before and after each treatment period. Treatment with CoQ10 resulted in a significant increase in total blood CoQ10 (138%; P = 0.02) and reduced blood CoQ10 (168%; P = 0.02), but did not improve exercise performance (with the exception of selected individuals) or impact oxidative stress. The relationship between the percentage change in total blood CoQ10 and the cycle sprint total work (R(2) = 0.6009) was noted to be moderate to strong. We conclude that treatment with CoQ10 in healthy, exercise-trained subjects increases total and reduced blood CoQ10, but this increase does not translate into improved exercise performance or decreased oxidative stress. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/22966414/Impact_of_oral_ubiquinol_on_blood_oxidative_stress_and_exercise_performance_ L2 - https://dx.doi.org/10.1155/2012/465020 DB - PRIME DP - Unbound Medicine ER -