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Observation of gastric mucosa in Bangladesh, the country with the lowest incidence of gastric cancer, and Japan, the country with the highest incidence.
Helicobacter. 2012 Oct; 17(5):396-401.H

Abstract

BACKGROUND

The prevalence of Helicobacter pylori (H. pylori) infection is high, but the incidence of gastric cancer is low in natives of Bangladesh. The gastric mucosa was observed in Bangladeshi patients to investigate the differences between Bangladeshis and Japanese.

MATERIALS AND METHODS

The study involved 418 Bangladeshi and 2356 Japanese patients with abdominal complaints who underwent endoscopy examinations and had no history of H. pylori eradication. The prevalence of H. pylori infection and the gastric mucosa in H. pylori-positive patients were compared between age-, gender-, and endoscopic diagnosis-matched Bangladeshi and Japanese subjects.

RESULTS

The prevalence of H. pylori infection was higher in Bangladeshi than in Japanese subjects (60.2 and 45.1%, respectively). All the scores for chronic inflammation, neutrophil activity, glandular atrophy, and intestinal metaplasia were significantly lower in H. pylori-positive Bangladeshis than in H. pylori-positive Japanese. The ratio of the corpus gastritis score (C) to the antrum gastritis score (A) (C/A ratio) was <1 (antrum-predominant gastritis) in all age groups of Bangladeshi subjects, whereas the C/A ratio changed from <1 to more than 1 (corpus-predominant gastritis) with aging in Japanese subjects.

CONCLUSIONS

The scores for glandular atrophy and intestinal metaplasia in H. pylori-positive Bangladeshis were significantly lower than those in Japanese. All age groups of Bangladeshis had antrum-predominant gastritis, whereas corpus-predominant gastritis was more common than antrum-predominant gastritis in older Japanese age groups. These results may explain the low incidence of gastric cancer in Bangladeshis and the high incidence in Japanese.

Authors+Show Affiliations

Department of Gastrointestinal Endoscopy, Tama-Nagayama University Hospital of Nippon Medical School, 1-7-1 Nagayama, Tama-city, Tokyo, 206-8512, Japan.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22967124

Citation

Matsuhisa, Takeshi, and Hafeza Aftab. "Observation of Gastric Mucosa in Bangladesh, the Country With the Lowest Incidence of Gastric Cancer, and Japan, the Country With the Highest Incidence." Helicobacter, vol. 17, no. 5, 2012, pp. 396-401.
Matsuhisa T, Aftab H. Observation of gastric mucosa in Bangladesh, the country with the lowest incidence of gastric cancer, and Japan, the country with the highest incidence. Helicobacter. 2012;17(5):396-401.
Matsuhisa, T., & Aftab, H. (2012). Observation of gastric mucosa in Bangladesh, the country with the lowest incidence of gastric cancer, and Japan, the country with the highest incidence. Helicobacter, 17(5), 396-401. https://doi.org/10.1111/j.1523-5378.2012.00967.x
Matsuhisa T, Aftab H. Observation of Gastric Mucosa in Bangladesh, the Country With the Lowest Incidence of Gastric Cancer, and Japan, the Country With the Highest Incidence. Helicobacter. 2012;17(5):396-401. PubMed PMID: 22967124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Observation of gastric mucosa in Bangladesh, the country with the lowest incidence of gastric cancer, and Japan, the country with the highest incidence. AU - Matsuhisa,Takeshi, AU - Aftab,Hafeza, Y1 - 2012/07/02/ PY - 2012/9/13/entrez PY - 2012/9/13/pubmed PY - 2013/1/24/medline SP - 396 EP - 401 JF - Helicobacter JO - Helicobacter VL - 17 IS - 5 N2 - BACKGROUND: The prevalence of Helicobacter pylori (H. pylori) infection is high, but the incidence of gastric cancer is low in natives of Bangladesh. The gastric mucosa was observed in Bangladeshi patients to investigate the differences between Bangladeshis and Japanese. MATERIALS AND METHODS: The study involved 418 Bangladeshi and 2356 Japanese patients with abdominal complaints who underwent endoscopy examinations and had no history of H. pylori eradication. The prevalence of H. pylori infection and the gastric mucosa in H. pylori-positive patients were compared between age-, gender-, and endoscopic diagnosis-matched Bangladeshi and Japanese subjects. RESULTS: The prevalence of H. pylori infection was higher in Bangladeshi than in Japanese subjects (60.2 and 45.1%, respectively). All the scores for chronic inflammation, neutrophil activity, glandular atrophy, and intestinal metaplasia were significantly lower in H. pylori-positive Bangladeshis than in H. pylori-positive Japanese. The ratio of the corpus gastritis score (C) to the antrum gastritis score (A) (C/A ratio) was <1 (antrum-predominant gastritis) in all age groups of Bangladeshi subjects, whereas the C/A ratio changed from <1 to more than 1 (corpus-predominant gastritis) with aging in Japanese subjects. CONCLUSIONS: The scores for glandular atrophy and intestinal metaplasia in H. pylori-positive Bangladeshis were significantly lower than those in Japanese. All age groups of Bangladeshis had antrum-predominant gastritis, whereas corpus-predominant gastritis was more common than antrum-predominant gastritis in older Japanese age groups. These results may explain the low incidence of gastric cancer in Bangladeshis and the high incidence in Japanese. SN - 1523-5378 UR - https://www.unboundmedicine.com/medline/citation/22967124/Observation_of_gastric_mucosa_in_Bangladesh_the_country_with_the_lowest_incidence_of_gastric_cancer_and_Japan_the_country_with_the_highest_incidence_ L2 - https://doi.org/10.1111/j.1523-5378.2012.00967.x DB - PRIME DP - Unbound Medicine ER -