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Foveal microstructure and functional parameters in lamellar macular hole.
Am J Ophthalmol. 2012 Dec; 154(6):974-980.e1.AJ

Abstract

PURPOSE

To evaluate the morphologic features of the photoreceptor layer (by spectral-domain optical coherence tomography) and functional parameters in patients with a lamellar macular hole.

DESIGN

Prospective, multicenter, observational case series.

METHODS

Fifty-four patients with lamellar macular hole were enrolled in the study. All patients underwent a complete ophthalmologic examination, including best-corrected visual acuity (BCVA) testing, MP1 microperimetry, and spectral-domain optical coherence tomography. For each patient, 2 experienced masked observers evaluated the integrity of photoreceptor inner segment/outer segment (IS/OS) junction and external limiting membrane (ELM) line.

RESULTS

Spectral-domain optical coherence tomography analysis showed complete integrity of the IS/OS junction and ELM line in 40 eyes (group A), partial or complete disruption of the IS/OS junction with an intact ELM line in 8 eyes (group B), and an alteration of both IS/OS junction and ELM line in 6 eyes (group C). Mean BCVA, total retinal sensitivity, and fixation stability were significantly better in groups A and B than in group C (both P < .05, Tukey-Kramer test), whereas there was no significant difference between groups A and B. Mean central retinal sensitivity was significantly different among all 3 groups (all P < .05, Tukey-Kramer test). The grade of integrity of the foveal photoreceptor layer was correlated significantly with mean BCVA (r = -0.57; P < .001), mean central retinal sensitivity (r = 0.52; P < .001), and total retinal sensitivity (r = 0.44; P < .001).

CONCLUSIONS

In lamellar macular hole, the morphologic features of the foveal photoreceptor layer consistently are correlated with BCVA and central retinal sensitivity. Preservation of the ELM is related to the maintenance of visual acuity.

Authors+Show Affiliations

Department of Ophthalmology, University of Catania, Catania, Italy. mreibaldi@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

22967862

Citation

Reibaldi, Michele, et al. "Foveal Microstructure and Functional Parameters in Lamellar Macular Hole." American Journal of Ophthalmology, vol. 154, no. 6, 2012, pp. 974-980.e1.
Reibaldi M, Parravano M, Varano M, et al. Foveal microstructure and functional parameters in lamellar macular hole. Am J Ophthalmol. 2012;154(6):974-980.e1.
Reibaldi, M., Parravano, M., Varano, M., Longo, A., Avitabile, T., Uva, M. G., Zagari, M., Toro, M., Boscia, F., Boccassini, B., Chiaravalloti, A., Mariotti, C., & Reibaldi, A. (2012). Foveal microstructure and functional parameters in lamellar macular hole. American Journal of Ophthalmology, 154(6), 974-e1. https://doi.org/10.1016/j.ajo.2012.06.008
Reibaldi M, et al. Foveal Microstructure and Functional Parameters in Lamellar Macular Hole. Am J Ophthalmol. 2012;154(6):974-980.e1. PubMed PMID: 22967862.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Foveal microstructure and functional parameters in lamellar macular hole. AU - Reibaldi,Michele, AU - Parravano,Mariacristina, AU - Varano,Monica, AU - Longo,Antonio, AU - Avitabile,Teresio, AU - Uva,Maurizio Giacinto, AU - Zagari,Marco, AU - Toro,Mario, AU - Boscia,Francesco, AU - Boccassini,Barbara, AU - Chiaravalloti,Adele, AU - Mariotti,Cesare, AU - Reibaldi,Alfredo, Y1 - 2012/09/08/ PY - 2012/01/17/received PY - 2012/06/17/revised PY - 2012/06/18/accepted PY - 2012/9/13/entrez PY - 2012/9/13/pubmed PY - 2013/1/31/medline SP - 974 EP - 980.e1 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 154 IS - 6 N2 - PURPOSE: To evaluate the morphologic features of the photoreceptor layer (by spectral-domain optical coherence tomography) and functional parameters in patients with a lamellar macular hole. DESIGN: Prospective, multicenter, observational case series. METHODS: Fifty-four patients with lamellar macular hole were enrolled in the study. All patients underwent a complete ophthalmologic examination, including best-corrected visual acuity (BCVA) testing, MP1 microperimetry, and spectral-domain optical coherence tomography. For each patient, 2 experienced masked observers evaluated the integrity of photoreceptor inner segment/outer segment (IS/OS) junction and external limiting membrane (ELM) line. RESULTS: Spectral-domain optical coherence tomography analysis showed complete integrity of the IS/OS junction and ELM line in 40 eyes (group A), partial or complete disruption of the IS/OS junction with an intact ELM line in 8 eyes (group B), and an alteration of both IS/OS junction and ELM line in 6 eyes (group C). Mean BCVA, total retinal sensitivity, and fixation stability were significantly better in groups A and B than in group C (both P < .05, Tukey-Kramer test), whereas there was no significant difference between groups A and B. Mean central retinal sensitivity was significantly different among all 3 groups (all P < .05, Tukey-Kramer test). The grade of integrity of the foveal photoreceptor layer was correlated significantly with mean BCVA (r = -0.57; P < .001), mean central retinal sensitivity (r = 0.52; P < .001), and total retinal sensitivity (r = 0.44; P < .001). CONCLUSIONS: In lamellar macular hole, the morphologic features of the foveal photoreceptor layer consistently are correlated with BCVA and central retinal sensitivity. Preservation of the ELM is related to the maintenance of visual acuity. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/22967862/Foveal_microstructure_and_functional_parameters_in_lamellar_macular_hole_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(12)00439-4 DB - PRIME DP - Unbound Medicine ER -