Tags

Type your tag names separated by a space and hit enter

Viral-bacterial interactions in acute otitis media.
Curr Allergy Asthma Rep. 2012 Dec; 12(6):551-8.CA

Abstract

Acute otitis media (AOM) is a polymicrobial disease, which usually occurs as a complication of viral upper respiratory tract infection (URI). While respiratory viruses alone may cause viral AOM, they increase the risk of bacterial middle ear infection and worsen clinical outcomes of bacterial AOM. URI viruses alter Eustachian tube (ET) function via decreased mucociliary action, altered mucus secretion and increased expression of inflammatory mediators among other mechanisms. Transient reduction in protective functions of the ET allows colonizing bacteria of the nasopharynx to ascend into the middle ear and cause AOM. Advances in research help us to better understand the host responses to viral URI, the mechanisms of viral-bacterial interactions in the nasopharynx and the development of AOM. In this review, we present current knowledge regarding viral-bacterial interactions in the pathogenesis and clinical course of AOM. We focus on the common respiratory viruses and their established role in AOM.

Authors+Show Affiliations

Division of Infectious Diseases, Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555-0371, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

22968233

Citation

Marom, Tal, et al. "Viral-bacterial Interactions in Acute Otitis Media." Current Allergy and Asthma Reports, vol. 12, no. 6, 2012, pp. 551-8.
Marom T, Nokso-Koivisto J, Chonmaitree T. Viral-bacterial interactions in acute otitis media. Curr Allergy Asthma Rep. 2012;12(6):551-8.
Marom, T., Nokso-Koivisto, J., & Chonmaitree, T. (2012). Viral-bacterial interactions in acute otitis media. Current Allergy and Asthma Reports, 12(6), 551-8. https://doi.org/10.1007/s11882-012-0303-2
Marom T, Nokso-Koivisto J, Chonmaitree T. Viral-bacterial Interactions in Acute Otitis Media. Curr Allergy Asthma Rep. 2012;12(6):551-8. PubMed PMID: 22968233.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Viral-bacterial interactions in acute otitis media. AU - Marom,Tal, AU - Nokso-Koivisto,Johanna, AU - Chonmaitree,Tasnee, PY - 2012/9/13/entrez PY - 2012/9/13/pubmed PY - 2013/4/11/medline SP - 551 EP - 8 JF - Current allergy and asthma reports JO - Curr Allergy Asthma Rep VL - 12 IS - 6 N2 - Acute otitis media (AOM) is a polymicrobial disease, which usually occurs as a complication of viral upper respiratory tract infection (URI). While respiratory viruses alone may cause viral AOM, they increase the risk of bacterial middle ear infection and worsen clinical outcomes of bacterial AOM. URI viruses alter Eustachian tube (ET) function via decreased mucociliary action, altered mucus secretion and increased expression of inflammatory mediators among other mechanisms. Transient reduction in protective functions of the ET allows colonizing bacteria of the nasopharynx to ascend into the middle ear and cause AOM. Advances in research help us to better understand the host responses to viral URI, the mechanisms of viral-bacterial interactions in the nasopharynx and the development of AOM. In this review, we present current knowledge regarding viral-bacterial interactions in the pathogenesis and clinical course of AOM. We focus on the common respiratory viruses and their established role in AOM. SN - 1534-6315 UR - https://www.unboundmedicine.com/medline/citation/22968233/Viral_bacterial_interactions_in_acute_otitis_media_ L2 - https://dx.doi.org/10.1007/s11882-012-0303-2 DB - PRIME DP - Unbound Medicine ER -