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Bone mineral density in adult celiac patients and the effect of gluten-free diet from childhood.
Am J Gastroenterol 1990; 85(1):51-3AJ

Abstract

Peripheral single photon absorptiometry was used to measure forearm bone mineral density in 22 celiacs on gluten-free diet from childhood (male 14, female 8, age 13-20) and 29 untreated adult celiacs at diagnosis (male 5, female 24, age 18-56, 14 with subclinical disease), compared with healthy sex- and age-matched controls. Bone mineral density was similar in patients treated from childhood and their controls [(668.4 +/- 65.3 vs. 654.9 +/- 69.6 mg/cm2, (mean +/- SD)], but significantly lower in untreated patients than in their controls (598.3 +/- 83.1 vs 673.2 +/- 42.7 mg/cm2, p less than 0.001). It was also significantly lower in the 12 younger untreated celiacs (18-28 yr) versus controls (619.4 +/- 68.5 vs 669.1 +/- 39.3 mg/cm2, p less than 0.01). In the untreated women, but not their controls, a negative correlation (p less than 0.05) was observed between bone mineral density and age. Bone mineral density did not correlate with severity of clinical or biochemical abnormalities. These results suggest that bone derangements are common in celiacs diagnosed in adulthood, even if they never presented evident malabsorption symptoms, and emphasize the importance of early diagnosis and treatment.

Authors+Show Affiliations

Patologia Medica III, Istituto di Scienze Mediche, Università di Milano, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2296964

Citation

Molteni, N, et al. "Bone Mineral Density in Adult Celiac Patients and the Effect of Gluten-free Diet From Childhood." The American Journal of Gastroenterology, vol. 85, no. 1, 1990, pp. 51-3.
Molteni N, Caraceni MP, Bardella MT, et al. Bone mineral density in adult celiac patients and the effect of gluten-free diet from childhood. Am J Gastroenterol. 1990;85(1):51-3.
Molteni, N., Caraceni, M. P., Bardella, M. T., Ortolani, S., Gandolini, G. G., & Bianchi, P. (1990). Bone mineral density in adult celiac patients and the effect of gluten-free diet from childhood. The American Journal of Gastroenterology, 85(1), pp. 51-3.
Molteni N, et al. Bone Mineral Density in Adult Celiac Patients and the Effect of Gluten-free Diet From Childhood. Am J Gastroenterol. 1990;85(1):51-3. PubMed PMID: 2296964.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone mineral density in adult celiac patients and the effect of gluten-free diet from childhood. AU - Molteni,N, AU - Caraceni,M P, AU - Bardella,M T, AU - Ortolani,S, AU - Gandolini,G G, AU - Bianchi,P, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 51 EP - 3 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 85 IS - 1 N2 - Peripheral single photon absorptiometry was used to measure forearm bone mineral density in 22 celiacs on gluten-free diet from childhood (male 14, female 8, age 13-20) and 29 untreated adult celiacs at diagnosis (male 5, female 24, age 18-56, 14 with subclinical disease), compared with healthy sex- and age-matched controls. Bone mineral density was similar in patients treated from childhood and their controls [(668.4 +/- 65.3 vs. 654.9 +/- 69.6 mg/cm2, (mean +/- SD)], but significantly lower in untreated patients than in their controls (598.3 +/- 83.1 vs 673.2 +/- 42.7 mg/cm2, p less than 0.001). It was also significantly lower in the 12 younger untreated celiacs (18-28 yr) versus controls (619.4 +/- 68.5 vs 669.1 +/- 39.3 mg/cm2, p less than 0.01). In the untreated women, but not their controls, a negative correlation (p less than 0.05) was observed between bone mineral density and age. Bone mineral density did not correlate with severity of clinical or biochemical abnormalities. These results suggest that bone derangements are common in celiacs diagnosed in adulthood, even if they never presented evident malabsorption symptoms, and emphasize the importance of early diagnosis and treatment. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/2296964/Bone_mineral_density_in_adult_celiac_patients_and_the_effect_of_gluten_free_diet_from_childhood_ L2 - https://medlineplus.gov/bonedensity.html DB - PRIME DP - Unbound Medicine ER -